Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia

Sponsor
Sunnybrook Health Sciences Centre
Study ID
NCT07279740
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • intermittent theta burst stimulation (iTBS) — DEVICE
    iTBS is a form of repetitive transcranial magnetic simulation (rTMS), a non-invasive form of brain stimulation.
  • Methylphenidate (MPH) — DRUG
    Participants will be on methylphenidate clinically prior to the trial

Study Details

This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed AD/vascular dementia

Key Dates

First listed
Dec 12, 2025
Start date
Jan 31, 2026
Status verified
Dec 2025
Primary completion
Oct 1, 2027
Completion
Oct 1, 2027

Study Design

Enrollment
12 participants (estimated)
Allocation
NA
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Methylphenidate + iTBS
    Participants are currently receiving methylphenidate and receive iTBS in this study.
  • Experimental: iTBS only
    iTBS only, no medication for apathy

Primary Outcome Measure

Change in Neuropsychiatric Inventory-Apathy (NPI-A) score [ Time Frame: 2 weeks ]

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