Brain disorders Clinical Trials

Recruiting brain disorders studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat brain disorders. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting brain disorders studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting brain disorders trials

Within

Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury

for Traumatic Brain Injury

1 site in Houston

Sponsor: Healing Hope International

Sex: All·Age: 6 - 75

Code: NCT07326059

Sodium Lactate in Severe TBI

for Traumatic Brain Injury

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 80

Code: NCT06701760·Phase 2

Double-Blind Clinical Trial of Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease

for Parkinson Disease

Sponsor: Mallory Hacker

Sex: All·Age: 50 - 75

Code: NCT06008717

Transcranial Magnetic Stimulation for Alzheimer's Disease Treatment

for Alzheimer Disease

Sponsor: Universitat Oberta de Catalunya

Sex: All·Age: 60 - 75

Code: NCT03121066

Study to Evaluate the Safety, Tolerability, Efficacy, and PK of FHL-301 in Parkinson's Disease Patients.

for Parkinson Disease

Sponsor: Forest Hills Lab

Sex: All·Age: 40 - 75

Code: NCT05931484·Phase 2

REstoring Flow by REvascularization With Submaximal Angioplasty in Hemodynamic IntraCranial Atherosclerotic Stenosis

for Intracranial Atherosclerotic Disease

1 site in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 30 - 90

Code: NCT03729817

The Feasibility and Acceptability of a Gait Training Program Based on Telerehabilitation After Stroke

for Stroke

Sponsor: University of Exeter

Sex: All·Age: 18+

Code: NCT07623018

Hearing Loss and Brain Health Study

for Hearing Loss, Adult-Onset

1 site in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 50+

Code: NCT07288463

Fall Prevention in Mild Cognitive Impairment

for Cognitive Impairment

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 65+

Code: NCT07507812

Concurrent Trials on Nature-Based Therapy for Inpatients in Dementia and Rehabilitation Medicine Wards

for Dementia

Sponsor: Changi General Hospital

Sex: All·Age: 21 - 100

Code: NCT07059390

ED PLWD/Care Partner Text Messaging

for Dementia

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07423871

Vagus Nerve Stimulation to Enhance Memory in Aging

for Alzheimer Disease

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07214194

The Disrupted Bodily Self of Patients

for Stroke

Sponsor: University of Geneva, Switzerland

Sex: All·Age: 20 - 85

Code: NCT04957576

Gaze and Gait Training With rTMS

for Mild Cognitive Impairment

Sponsor: University of Florida

Sex: All·Age: 18 - 80

Code: NCT05864313

Adapting Changing Talk: Online (CHATO) to CHATO-Inclusive

for Dementia

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06636214

Optimal Dosing of High-Intensity Locomotor Training for Step Attainment and Locomotor Outcomes in Stroke Patients Undergoing Acute Inpatient Rehabilitation

for Stroke

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18 - 95

Code: NCT06637839

Effects of Task-Oriented Sit-to-Stand Training Using Immersive VR and PNF on Quality of Life in Chronic Stroke: Trial Protocol

for Stroke

Sponsor: Universidad Nacional Autonoma de Mexico

Sex: All·Age: 35 - 71

Code: NCT07713446

Paired VNS For TBI Rehabilitation

for Traumatic Brain Injury

Sponsor: Stony Brook University

Sex: All·Age: 22 - 80

Code: NCT07719829

Exercise With and Without Cognitive Training

for Multiple Sclerosis

1 site in Decatur

Sponsor: VA Office of Research and Development

Sex: All·Age: 55 - 85

Code: NCT07447115

Clinical Efficacy of Exoskeleton Assistance for Individuals Post-Stroke

for Stroke

1 site in Atlanta

Sponsor: Georgia Institute of Technology

Sex: All·Age: 18 - 85

Code: NCT06064604

A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia

for Schizophrenia

Sponsor: European Group for Research In Schizophrenia

Sex: All·Age: 18 - 55

Code: NCT07084831·Phase 3

A Study on the Application of Positive Psychological Counseling Based on "Dou Bao" Software in Patients With Post-stroke Depression

for Stroke

Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07336888

Relaxin Therapy for Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Deeptankar DeMazumder

Sex: All·Age: 18+

Code: NCT07359872·Phase 1, Phase 2

The CDAC Study - Cerebral Dysfunction After Coronary Revascularization

for CABG

Sponsor: The Scripps Research Institute

Sex: All·Age: 18+

Code: NCT07491120

Electroconvulsive Therapy for Treatment of Alzheimer´s Disease

for Alzheimer's Disease

Sponsor: Central Institute of Mental Health, Mannheim

Sex: All·Age: 65+

Code: NCT02438202

Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Amyotrophic Lateral Sclerosis (ALS)

for Amyotrophic Lateral Sclerosis

Sponsor: Q Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT02478450·Phase 1, Phase 2

Improving Awareness for Spatial Neglect With tDCS

for Stroke

Sponsor: University of Geneva, Switzerland

Sex: All·Age: 20 - 85

Code: NCT04845529

Tricaprilin Phase 3 ALTER-AD (Alternative-Alzheimer Disease) Study

for Alzheimer Disease

Sponsor: Cerecin

Sex: All·Age: 55 - 85

Code: NCT05809908·Phase 3

Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury

for Mild Traumatic Brain Injury

1 site in Fort Hood

Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07327567

Computerized Decision Support to Prevent Stroke in Atrial Fibrillation

for Atrial Fibrillation

2 sites incl. Edgewood

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06355986

Assessment of Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments

for Stroke

Sponsor: Motion Informatics LTD

Sex: All·Age: 18 - 80

Code: NCT07396922

Lead Exposure and Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Assiut University

Sex: All·Age: 20 - 50·Accepts healthy volunteers

Code: NCT07423312

Minocycline In Neurocognitive Outcomes - Sickle Cell Disease

for Sickle Cell Disease

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05605366·Phase 1

Autologous Hematopoietic Stem Cell Transplantation for Refractory Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Tianjin Medical University General Hospital

Sex: All·Age: 18 - 60

Code: NCT06228781

Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care

for Multiple Sclerosis

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT06386133

Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog

for Mild Cognitive Impairment

1 site in Columbus

Sponsor: Ohio State University

Sex: All·Age: 50+

Code: NCT06542458

Low Intensity Focused Ultrasound for Parkinson's Disease

for Parkinson Disease

Sponsor: Ali Rezai

Sex: All·Age: 45 - 80

Code: NCT06763692

Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke

for Stroke

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06875206

A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease

for Alzheimer's Disease

Sponsor: Hoffmann-La Roche

Sex: All·Age: 55 - 80

Code: NCT07717411·Phase 3

Alzheimer's Tau Platform: Regimen A - AADvac1

for Preclinical Alzheimer's Disease

1 site in San Francisco

Sponsor: Paul S. Aisen

Sex: All·Age: 50 - 80

Code: NCT07167966·Phase 2

A Behavioral Digital Intervention For Parkinson's Disease

for Parkinson Disease

Sponsor: Egas Moniz - Cooperativa de Ensino Superior, CRL

Sex: All·Age: 18+

Code: NCT07705620

Parent-Child Interaction Therapy (PCIT) for Children With Traumatic Brain Injury (TBI): A Stepped-Care Model

for Traumatic Brain Injury

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 2+

Code: NCT06193382

Robot-Assisted Meditation for Older Adults With Cognitive Concerns

for Cognitive Impairment

Sponsor: Johns Hopkins University

Sex: All·Age: 65 - 80

Code: NCT07435220

Study of Low-intensity Focused Ultrasound Effects on Cognitive fMRI Signals

for Cognitive Change

Sponsor: Virginia Polytechnic Institute and State University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05303428

Cholinergic Enhancement of Theta

for Epilepsy

1 site in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07228338·EARLY_Phase 1

Feasibility of A Smartphone Application Intervention in Community Settings: A Pretest-Posttest Pilot Study

for Aging

1 site in Galveston

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 50 - 100·Accepts healthy volunteers

Code: NCT07313540

(MAP) Pilot Randomized Controlled Trial for Older Adults With Mild Cognitive Impairment and Elevated Stress

for Mild Cognitive Impairment (MCI)

Sponsor: Rush University Medical Center

Sex: All·Age: 65+

Code: NCT07389655

Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns

for Subjective Cognitive Decline (SCD)

Sponsor: Johns Hopkins University

Sex: All·Age: 65+

Code: NCT07440498

A Biosimilar Trial to Investigate PK, PD, Safety With PB018 Versus US-licensed Ocrevus and EU-approved Ocrevus

for Multiple Sclerosis

Sponsor: Polpharma Biologics International AG

Sex: All·Age: 18 - 65

Code: NCT07606521·Phase 1

A Phase 2b/3 Clinical Study Evaluating T3D-959 in Mild-to-Moderate Alzheimer's Disease Subjects

for Alzheimer's Disease

1 site in Durham

Sponsor: T3D Therapeutics, Inc.

Sex: All·Age: 50 - 90

Code: NCT06964230·Phase 2, Phase 3

The Care for America's Aging Study

for Cognitive Impairment

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 60+

Code: NCT06021704

Behavioral and/or Mirabegron to Treat Urinary Symptoms in Parkinson Disease

for Overactive Bladder

3 sites incl. Decatur

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07187466·Phase 4

AI-Assisted Workflow for Occult Atrial Fibrillation Detection After Ischemic Stroke: A Prospective Randomized Trial

for Atrial Fibrillation

Sponsor: National Taiwan University Hospital

Sex: All·Age: 18+

Code: NCT07540065

Multicomponent Intervention to Improve Cognitive Abilities in Older Adults With Mild Cognitive Impairment

for Mild Cognitive Impairment (MCI)

Sponsor: City University of Hong Kong

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07549074

Cognitive Musical Screening and Therapeutic Innovation in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Hunter College of City University of New York

Sex: All·Age: 18+

Code: NCT07552428

hCG Treatment for Rehabilitation From a TBI

for Traumatic Brain Injury

1 site in Madison

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18 - 65

Code: NCT07557615·EARLY_Phase 1

Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut Syndrome

for Lennox Gastaut Syndrome (LGS)

Sponsor: University of Minnesota

Sex: All·Age: 18 - 65

Code: NCT07568860

PIRe 2.0: A Stepped-Care Model for Involving Relatives Across Sectors

for Brain Injuries, Acute

Sponsor: Rigshospitalet, Denmark

Sex: All·Age: 18+

Code: NCT07590726

This Study Evaluates the Use of a Data-driven Lower Limb Exoskeleton Controller for Stroke Rehabilitation.

for Stroke

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07616167

Neural Basis of Cognition

for Epilepsy

Sponsor: Duke University

Sex: All·Age: 12+

Code: NCT05132543

Brain disorders clinical trials — common questions

Are brain disorders clinical trials free to join?

Yes. Participating in a brain disorders clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a brain disorders clinical trial?

Each brain disorders study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a brain disorders trial near me?

Use the location controls above. We'll show recruiting brain disorders trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many brain disorders trials are recruiting right now?

We're currently tracking roughly 1729 recruiting brain disorders trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Brain disorders trials by city

Boston, MA Chicago, IL Birmingham, AL San Francisco, CA Los Angeles, CA Cleveland, OH Gainesville, FL Miami, FL Aurora, CO Indianapolis, IN Palo Alto, CA Sacramento, CA

Conditions in this area

Alzheimer's disease Mild cognitive impairment (MCI)Dementia Parkinson's disease Multiple sclerosis Epilepsy Stroke Traumatic brain injury (TBI)ALS (amyotrophic lateral sclerosis)Huntington disease Myasthenia gravis Essential tremor Cognitive impairment / decline Aphasia