A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

Part of paid clinical trials in Chula Vista, California.

Sponsor
Renibus Therapeutics, Inc.
Study ID
NCT07355062
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

  • CKD
  • Metabolic Acidosis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Veverimer — DRUG
    Group 1: 9 g veverimer BID
  • Placebo — DRUG
    Group 2: 9 g PBO BID

Study Details

The purpose of this 264 week study is is to evaluate the efficacy and safety of veverimer in treating adults with moderate-to-severe chronic kidney disease (CKD) and metabolic acidosis.

Key Dates

First listed
Jan 21, 2026
Start date
Jan 13, 2026
Status verified
May 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Veverimer
  • Placebo Comparator: Placebo

Primary Outcome Measure

Efficacy of Veverimer by measuring change in serum bicarbonate concentration (SBC) [ Time Frame: Visits: Screening to Day 168 ]

Central Contacts

Locations (21)

FacilityCityStateZIPSite coordinators
California Institute of Renal ResearchChula VistaCalifornia91910-
Academic Medical Research InstituteLos AngelesCalifornia90022-
UC Davis Health, Dept of Internal MedicineSacramentoCalifornia95817-
California Institute of Renal Research - San DiegoSan DiegoCalifornia92111-
Renal Research Office, University of Colorado Anschutz Medical CampusAuroraColorado80045-
Velocity Clinical ResearchEdgewaterFlorida32132-
Belkis Delgado MD PAMiami SpringsFlorida33166-
ClinTrial Research - OakwaterOrlandoFlorida32806-
Southeastern Clinical Research InstituteAugustaGeorgia30904-
CARE Institute - Boise KidneyBoiseIdaho83706-
Idaho Kidney - CARE InstituteChubbuckIdaho83201-
CARE Institute - Idaho FallsIdaho FallsIdaho83401-
Research by DesignChicagoIllinois60643-
Indiana University School of MedicineIndianapolisIndiana46202-
Nephrology Associates of KentuckianaLouisvilleKentucky40205-
JCCT-Clinical Research ConsultantsKansas CityMissouri64111-
New York-Presbyterian QueensFresh MeadowsNew York11365-
Brookview Hills Research AssociatesWinston-SalemNorth Carolina27103-
Texas Center for Kidney Disease ResearchFort WorthTexas76110-
Prolato Clinical Research CenterHoustonTexas77054-
Clinical Advancement CenterSan AntonioTexas78212-

Find similar trials in Chula Vista, CA

By condition
Chronic kidney disease
By specialty
NephrologyKidney disease
By research site
California Institute of Renal Research· Chula Vista, CAAcademic Medical Research Institute· Los Angeles, CAUC Davis Health, Dept of Internal Medicine· Sacramento, CACalifornia Institute of Renal Research - San Diego· San Diego, CARenal Research Office, University of Colorado Anschutz Medical Campus· Aurora, COVelocity Clinical Research· Edgewater, FL

Related Studies