High Frequency Stimulation to Improve Cognition, Mobility, and Affect in Individuals With and Without Subjective Cognitive Decline

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT07395609
Status
Recruiting
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Conditions

  • Healthy Subjects
  • Subjective Cognitive Decline (SCD)

Eligibility Criteria

Sex
ALL
Age
65 Years - 89 Years
Healthy Volunteers
Accepted

Interventions

  • Experimental -- 16.67 Hz Visual Occlusion — BEHAVIORAL
    This group will wear visual occlusion glasses with visible stimulation at 16.67 Hz (corresponding to flicker of 32-36 Hz)
  • Control - 1Hz Visual Occlusion — BEHAVIORAL
    This group will wear visual occlusion glasses with visible stimulation at 1 Hz

Study Details

The goal is to determine whether three months of at least three times / week of sensory flicker stimulation improves cognition, mobility, and affect in healthy older adults and older adults with and without Subjective Cognitive Decline (SCD). Investigators will also determine whether the intervention slows cortical thinning and declines in brain functional network segregation and changes in blood biomarkers of Alzheimer's Disease (AD).

Key Dates

First listed
Feb 9, 2026
Start date
Aug 3, 2026
Status verified
Aug 2025
Primary completion
Oct 31, 2028
Completion
Oct 31, 2028

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Sham Comparator: Control
    Participants in this group will receive the control stimulation at the slower rate.
  • Experimental: Experimental
    Participants in this group will receive the experimental stimulation at the faster rate.

Primary Outcome Measure

Cognition - The Tablet-based Cognitive Assessment Tool (TabCAT) [ Time Frame: Baseline, halfway through (1.5 months), and post-intervention (3 months) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32611
Rachael Seidler, PhD
[email protected]
734-834-0385
[email protected]
Natalie C. Ebner, PhD (SUB_INVESTIGATOR)
Rachael Seidler, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Florida· Gainesville, FL

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