Clinical Trial on a Natural Compound to Improve Chronic Inflammation After SARS-CoV-2 Infection

Sponsor
Universidad Católica San Antonio de Murcia
Study ID
NCT07397910
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Experimental Product — DIETARY_SUPPLEMENT
    Supplement consisting of orange extract, apigenin, luteolin, yerba mate extract, grapefruit extract, and olive leaf extract.
  • Control placebo — DIETARY_SUPPLEMENT
    Product with identical characteristics to the experimental product.
  • Physical exercise — OTHER
    During the study, subjects will have to develop a training program. A multicomponent program will be carried out during the 4 months of product consumption. The sessions will last 60 minutes and will be held 2-3 times per week.
  • No Physical Exercise — OTHER
    During the study, subjects will only consume the product assigned to them in the randomization.

Study Details

A controlled, randomized clinical trial is proposed to demonstrate the effectiveness of the experimental product in controlling hepato-pulmonary inflammation and neurovascular encephalic inflammation, which may constitute the etiopathogenic basis of persistent COVID. In addition, an individualized training program will be implemented for each participant in order to improve chronic symptoms and, consequently, their quality of life.

Key Dates

First listed
Feb 9, 2026
Start date
Feb 23, 2026
Status verified
Feb 2026
Primary completion
Jul 6, 2026
Completion
Aug 3, 2026

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Placebo Comparator: Placebo
    Subjects in this group will consume a placebo product (maltodextrin) with the same organoleptic characteristics as the investigational product.
  • Experimental: Natural extract
    Subjects in this group will consume the investigational product (experimental product composed of a combination of six natural extracts: grapefruit extract, apigenin, orange extract, luteolin, yerba mate extract, and olive leaf extract).
  • Experimental: Physical exercise and consumption of experimental product
    During the study, subjects must consume the experimental product and also follow a training program. A multi-component program will be carried out during the 4 months of product consumption. Sessions will last 60 minutes and will be held 2-3 times per week.
  • Placebo Comparator: Physical exercise and consumption of placebo product
    During the study, subjects must consume the placebo product and also follow a training program. A multi-component program will be carried out during the 4 months of product consumption. Sessions will last 60 minutes and will be held 2-3 times per week.

Primary Outcome Measure

Immunoinflammatory profile [ Time Frame: Blood samples will be taken twice, once at baseline, at the beginning of the trial and once at the end after 120 days of product intake. ]

Central Contacts

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