Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease

Conditions

To learn if gadopiclenol (a contrast agent) used during MRI scanning can help in the detection of early LMD.

Other: MRI Scan with Gadavist (gadobutrol) / VUEWAY (gadopiclenol)
Participants found to be eligible to take part in this study and agree to take part, will have brain MRI scans as part of standard of care. Then, within a week (preferably within 48 hours) of the participants routine brain MRI scans, you will have LMD-focused brain MRI scans with gadopiclenol contrast. Specifically, MRI scans will be done immediately after a small amount of gadopiclenol is given through an IV catheter placed into a vein, and then at 10 and 30 minutes thereafter. Then, a second dose of gadopiclenol will be given, and MRI scans will be done immediately after. The MRI scans performed for research purposes will take approximately 50 minutes to complete. You will be followed by routing clinical and imaging guidelines for 6 months or until the confirmation of LMD (whichever comes first).

Safety and adverse events (AEs) [ Time Frame: Through study completion; an average of 1 year. ]

Facility	City	State	ZIP	Site coordinators
MD Anderson Cancer Center	Houston	Texas	77030	Rami Eldaya, MD [email protected] 713-745-2945 Rami Eldaya, MD (PRINCIPAL_INVESTIGATOR)

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