3D Virtual Resection for Predicting Lung Function in VATS

Sponsor
National Taiwan University Hospital
Study ID
NCT07436598
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Study Details

This study aims to validate a novel preoperative assessment strategy using three-dimensional (3-D) computed tomography (CT) reconstruction and virtual resection simulation. The goal is to accurately predict postoperative pulmonary function in patients with non-small cell lung cancer (NSCLC) undergoing Video-Assisted Thoracoscopic Surgery (VATS) anatomical resection. Accurate prediction of postoperative lung function is crucial for patient safety. Traditional methods, such as segment counting, often lack precision because they assume all lung segments contribute equally to function, ignoring variations caused by tumors or emphysema. This study utilizes 3-D "virtual resection" to quantify the "Planned Resected Ventilated Lung Volume Fraction" (pRVLVF) before surgery. The study will recruit 60 participants divided into two groups: those undergoing lobectomy (n=30) and those undergoing segmentectomy (n=30). Participants will undergo standard thin-slice CT scans and pulmonary function tests (PFT) before surgery. Postoperatively, lung function and recovery will be tracked at 3, 6, and 12 months to develop a dynamic prediction model and evaluate the compensatory capacity of the residual lung.

Key Dates

First listed
Feb 27, 2026
Start date
Apr 7, 2026
Status verified
Feb 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: VATS Segmentectomy Group
    Patients with non-small cell lung cancer scheduled to undergo video-assisted thoracoscopic segmentectomy.
  • Arm: VATS Lobectomy Group
    Patients with non-small cell lung cancer scheduled to undergo video-assisted thoracoscopic lobectomy.

Primary Outcome Measure

Mean Absolute Error (MAE) of Predicted Postoperative FEV1 [ Time Frame: 3 months post-operation ]

Central Contacts

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