Lung oncology Clinical Trials

Recruiting lung oncology studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat lung oncology. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting lung oncology studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting lung oncology trials

Within

PulmoSalud: Multimodal Program for Prehabilitation and Early Home Rehabilitation in Patients With Lung Cancer

for Lung Cancer

Sponsor: FranciscoVeraSerrano

Sex: All·Age: 18+

Code: NCT07478276

Multinational Observational Study to Describe Diagnostic Stage Shift in Patients With Lung Cancer Using Medical Records

for Lung Cancer

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06842056

Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial

for Lung Non-Small Cell Carcinoma

14 sites incl. Newark

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07388524·Phase 3

Apply to this trial

ctDNA-Guided Intraventricular Therapy for CNS Malignancies

for Leptomeningeal Disease

Sponsor: Alireza Mansouri

Sex: All·Age: 18 - 120

Code: NCT07689721

Dissemination Of Lung Cancer Screening Education Through Tobacco Quitlines

for Lung Cancer

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07720141

A Multicenter Randomized Open-Label Trial Evaluating MRD-Guided Interruption Versus Standard of Care Immune-Checkpoint Inhibitor (ICI) Therapy In Patients With Advanced / Metastatic Solid Tumors.

for NSCLC (Advanced Non-small Cell Lung Cancer)

Sponsor: Natera, Inc.

Sex: All·Age: 18+

Code: NCT07689812

Respiratory Muscle Training in Patients Undergoing Lung Cancer Surgery

for Lung Cancer

Sponsor: Saglik Bilimleri Universitesi

Sex: All·Age: 18 - 70

Code: NCT07499986

A Study Evaluating The Combination of Immunotherapy With Radiotherapy in Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07603856·Phase 2

Apply to this trial

3-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary Segmental Resection Trial

for Non Small Cell Lung Cancer

Sponsor: St. Joseph's Healthcare Hamilton

Sex: All·Age: 18+

Code: NCT06638125·Phase 1, Phase 2

Phase II Study of Upfront SRT Plus Ivonescimab/Chemotherapy vs Ivonescimab/Chemotherapy in NSCLC Brain Mets

for Non Small Cell Lung Cancer

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT07234877·Phase 2

Ph1/2 Trial Of Navlimetostat With Pumitamig In MTAP-Deficient Advanced Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07579221·Phase 1, Phase 2

An Educational Intervention (Lung Toolkit) for Improving Knowledge About Lung Cancer and Screening Among American Indian and Alaskan Native Cigarette Smokers, Lung PATHS Trial

for Lung Carcinoma

1 site in Seattle

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT07615764

Cemiplimab for Clinical Stage I, 2-3.9cm, Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 80

Code: NCT07720167·Phase 2

Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones

for Anatomic Stage IV Breast Cancer AJCC v8

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06982222·Phase 1

Tailored Patient Navigation to Improve the Uptake of Lung Cancer Screening in Tribal Communities in Western Washington State, SACRED LUNGS Trial

for Lung Carcinoma

2 sites incl. Auburn

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07176000

Totally Robotic Versus Surgeon-Assisted Robotic Lung Resection For Early-Stage NSCLC

for Lung Cancer

Sponsor: St. Joseph's Healthcare Hamilton

Sex: All·Age: 18 - 120

Code: NCT06348030

The Selective Personalized Radio-Immunotherapy for Locally Advanced Non-Small Cell Lung Cancer Trial 2

for Non-small Cell Lung Cancer

1 site in The Bronx

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT07146230·Phase 2

Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)

for Non-Small Cell Lung Cancer

34 sites incl. Beverly Hills

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07680790·Phase 3

Lumbar Punctures for the Detection of ctDNA in the Cerebrospinal Fluid of Patients With Stage III and IV Non-Small Cell Lung Cancer

for Lung Non-Small Cell Carcinoma

1 site in Columbus

Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All·Age: All ages

Code: NCT06816979

Study for Evaluating the Safety and Feasibility of Fecal Microbiota Transplant in Stage II-III NSCLC Patients Using ICI Responders as Donors (MIGRANT)

for Non Small Cell Lung Cancer

Sponsor: Fundación GECP

Sex: All·Age: 18+

Code: NCT07247786·Phase 2

A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving Pembrolizumab

for Metastatic Lung Non-Small Cell Carcinoma

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07619599·Phase 1

SMARCA4/2 Inhibitor for POU2F3-Positive SCLC

for Small Cell Lung Cancer

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07551635·Phase 2

Vapor Ablation for Localized Cancer Lesions

for Non Small Cell Lung Cancer

Sponsor: Uptake Medical Technology, Inc.

Sex: All·Age: 18+

Code: NCT03514329

SX-682 and Atezolizumab for the Treatment of Advanced or Metastatic, Recurrent Non-small Cell Lung Cancer

for Advanced Lung Non-Small Cell Carcinoma

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07322341·Phase 2

A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07541170·Phase 3

Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial

for Clinical Stage III Cutaneous Melanoma AJCC v8

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 18+

Code: NCT07576725·Phase 2

A Non-interventional, Real-world Study on the Adjuvant Treatment of Chinese EGFR-positive Stage IA NSCLC Patients With High-risk Factors Using Third-generation EGFR-TKIs.

for Non-Small Cell Lung Cancer

Sponsor: First Affiliated Hospital of Guangxi Medical University

Sex: All·Age: 18+

Code: NCT07686185

In Vitro NSCLC EGFR-Mutant Models for Drug Sensitivity Testing

for Carcinoma, Non-Small-Cell Lung

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07697716

Population Health Management -Increase Lung Cancer Screening in Community Health Centers (LungSMART)

for Lung Cancer

1 site in Salt Lake City

Sponsor: University of Utah

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT07599943

SKB264 in Combination With SKB118 for Non-Small Cell Lung Cancer

for NSCLC

Sponsor: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07697586·Phase 2

FAPI PET Imaging - An Exploratory Study

for Thyroid Pathology

Sponsor: Martin Huellner

Sex: All·Age: 18+

Code: NCT07705074·Phase 1, Phase 2

A Study to Test Obrixtamig in Combination With ZL-1310 in People With Advanced Small Cell Lung Cancer or Other Neuroendocrine Cancers

for Small Cell Lung Cancer

2 sites incl. Washington D.C.

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07707895·Phase 1, Phase 2

Photoimmunotherapy With ASP-1929 and Cemiplimab for the Treatment of Refractory, Inoperable, and Metastatic Stage IIIB-IV Non-small Cell Lung Cancer

for Lung Non-Small Cell Carcinoma

1 site in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06943664·Phase 2

A Restorative Justice-Based Lung Cancer Screening Decision-Making Support Intervention Tailored for Black Individuals to Increase Lung Cancer Screening Among Black Community Members, RESTORE Trial

for Lung Carcinoma

1 site in Seattle

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 50 - 77·Accepts healthy volunteers

Code: NCT07490860

Apply to this trial

Home-Based Respiratory Muscle Training and Aerobic Exercise Programs to Improve Lung Health in Current and Former Cigarette Smokers

for Lung Carcinoma

1 site in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT07553819

Management Strategy of 1L Lorlatinib With Hyperlipidemia in Stage IIIB-IV ALK Positive NSCLC

for Non-Small Cell Lung Cancer (NSCLC)

Sponsor: Sun Yat-sen University

Sex: All·Age: 18+

Code: NCT07674524

Two-Point Versus Single-Point Serratus Anterior Plane Block for Post-Thoracoscopic Surgery Analgesia

for Lung Cancer

Sponsor: Shiyou Wei

Sex: All·Age: 18 - 85

Code: NCT07700823

Overcoming Resistance to Immunotherapy Combining Gemcitabine With Ivonescimab in Advanced NSCLC

for NSCLC

Sponsor: Swiss Cancer Institute

Sex: All·Age: 18+

Code: NCT07158489·Phase 2

Precise Exercise Regimen for Cancer Care (PERCC): A Pilot Study

for Stage II Lung Cancer

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07412041

AIRCARE (Air Pollution and Cancer Research Ecosystem): Center for Advanced Research on Environmental Health and Lung Cancer Risk

for Lung Cancer

Sponsor: All India Institute of Medical Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07553598

Adebrelimab or Retlirafusp Alfa Plus Recaticimab and Chemotherapy for Resectable NSCLC

for Non Small Cell Lung Cancer

Sponsor: Peking University Cancer Hospital & Institute

Sex: All·Age: 18 - 75

Code: NCT07567326·Phase 2

TCR1188-ABC Cells in KRAS-mutated Cancers

for Cholangiocarcinoma

1 site in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07594067·Phase 1

Apply to this trial

Observational Study That Will Analyse the Spread and Stratification of Lung Cancer Risk Using Artificial Intelligence

for Lung Cancer

Sponsor: AstraZeneca

Sex: All·Age: 50 - 80

Code: NCT07617636

A Study of SKB571 Combination Therapy in Participants With Non-Small Cell Lung Cancer (NSCLC)

for Non-Small Cell Lung Cancer

Sponsor: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07622186·Phase 2

Study of LT-010391 in Participants With KRAS G12D-Mutant Solid Tumors

for Non-small Cell Lung Cancer (NSCLC)

Sponsor: Leadingtac Pharmaceutical (Shaoxing) Co., Ltd.

Sex: All·Age: 18+

Code: NCT07624214·Phase 1

A Study of CLSP 5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors (SENTINEL-101)

for Advanced Solid Tumor

4 sites incl. Durham

Sponsor: Clasp Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07650357·Phase 1

Comparative ¹⁸F-FDG and ⁶⁸Ga-MY6349 PET/CT Imaging for Assessing TROP2 ADC Therapeutic Efficacy in EGFR-TKI Resistant Advanced NSCLC

for NSCLC

Sponsor: Zhou Chengzhi

Sex: All·Age: 18+

Code: NCT07685197·Phase 2

Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease

for Chest Wall Tumor

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07685938·Phase 2

Segmentectomy Versus Lobectomy for Deep Solid-Dominant Early-Stage NSCLC

for Non-Small Cell Lung Cancer

Sponsor: Shanghai Chest Hospital

Sex: All·Age: 18 - 80

Code: NCT07698990

HSK41959 With Standard Therapy in Solid Tumors With MTAP Deletion

for Non-Small Cell Lung Cancer

Sponsor: Haisco Pharmaceutical Group Co., Ltd.

Sex: All·Age: 18+

Code: NCT07699757·Phase 1

Investigating the Combination of Bexmarilimab and Nivolumab in Solid Tumours, Melanoma and NSCLC

for Melanoma (Skin Cancer)

Sponsor: Institute of Cancer Research, United Kingdom

Sex: All·Age: 18+

Code: NCT07718243·Phase 1, Phase 2

QL1706 Plus Anlotinib as a Later-line Treatment for Patients With Advanced Lung Cancer

for Small Cell Lung Cancer

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 80

Code: NCT07636226·Phase 2, Phase 3

A Real World Study of Participants With Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor Mutation (EGFRm)

for Carcinoma, Non-Small-Cell Lung

Sponsor: Janssen-Cilag Farmaceutica Ltda.

Sex: All·Age: 18+

Code: NCT07680907

The Efficacy and Safety of Trastuzumab Deruxtecan in Advanced or Metastatic NSCLC With HER2 Over Expression

for NSCLC

Sponsor: Hunan Province Tumor Hospital

Sex: All·Age: 18+

Code: NCT07662473·Phase 2

Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer (NSCLC)

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06694454·Phase 1, Phase 2

Apply to this trial

A Study to Learn About the Study Medicine Called Ponsegromab in Adults With Lung Cancer-Associated Significant Weight Loss

for Non-small Cell Lung Cancer (NSCLC)

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07663630·Phase 1

A Study of Neoadjuvant Amivantamab With Either Lazertinib or Chemotherapy in Participants With Resectable EGFR-Mutated NSCLC

for Carcinoma, Non-Small-Cell Lung

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07586202·Phase 2

Apply to this trial

Evaluation of XYA02 in Patients With Advanced Solid Tumors

for MUC1-expressing Advanced, Relapsed and/or Refractory Solid Tumors

Sponsor: XYone Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT07670312·Phase 1, Phase 2

A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment

for Lung Non-Small Cell Carcinoma

33 sites incl. Jonesboro

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07293247·Phase 2

Apply to this trial

A Study to Investigate ANS02 in Participants With EGFR Mutation-Positive Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

1 site in Fairfax

Sponsor: Avistone Biotechnology Co., Ltd.

Sex: All·Age: 18+

Code: NCT07538804·Phase 1, Phase 2

Apply to this trial

Lung oncology clinical trials — common questions

Are lung oncology clinical trials free to join?

Yes. Participating in a lung oncology clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a lung oncology clinical trial?

Each lung oncology study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a lung oncology trial near me?

Use the location controls above. We'll show recruiting lung oncology trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many lung oncology trials are recruiting right now?

We're currently tracking roughly 579 recruiting lung oncology trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Lung oncology trials by city

Los Angeles, CA Boston, MA Duarte, CA Birmingham, AL Chicago, IL La Jolla, CA Aurora, CO Orange, CA Sacramento, CA San Francisco, CA Seattle, WA Beverly Hills, CA

Conditions in this area

Lung cancer Non-small cell lung cancer (NSCLC)Small cell lung cancer Mesothelioma