Comparison of Root Canal Desinfection Protocols

Part of paid clinical trials in Buffalo, New York.

Sponsor: State University of New York at Buffalo
Study ID: NCT07439614
Status: Recruiting

Apply to this trial

Conditions

Periapical Periodontitis

Eligibility Criteria

Sex: ALL
Age: 18 Years - 70 Years
Healthy Volunteers: Accepted

Interventions

Desinfection device — DEVICE
Desinfection protocol with (LAI): Er,Cr:YSGG laser (2780 nm) delivered with a radial-firing tip.
Analytical microbiological methods — DEVICE
Endocator: Measures ATP levels (Endoscore and RLU) to rapidly assess bacterial load in less than one minute.

Study Details

Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis

Key Dates

Start date: Apr 1, 2026
Status verified: Jun 2026
Primary completion: Dec 31, 2026
Completion: Jun 30, 2027

Study Design

Enrollment: 50 participants (estimated)
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Arms

Active Comparator: Desinfection device
Ultrasonic Activation: Piezoelectric ultrasonic unit (Dentsply International) with an Irrisafe tip (Satelec/Acteon).
Active Comparator: Analytical microbiological method
qPCR assay: Quantifies total bacterial DNA using 16S rRNA gene amplification.

Primary Outcome Measure

Reduction of bacteria in the root canal system [ Time Frame: Immediately after the irrigation activation procedure, ATP levels will be measured, and qPCR analysis will be performed at the end of the study, once all samples have been collected. ]

Central Contacts

Stephen Lyon, DDS
(716) 829-6229
[email protected]
Thamyres Monteiro, MSc
(716) 829-6199
[email protected]

Locations (1)

Facility	City	State	ZIP	Site coordinators
Advance Education in Endodontics Program	Buffalo	New York	14214	-

Find similar trials in Buffalo, NY

By research site

Advance Education in Endodontics Program· Buffalo, NY