Memory Enhancement in Aging With Optimal Dosing

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Boston University Charles River Campus
Study ID
NCT07461584
Status
Recruiting
Apply to this trial

Conditions

  • Aging
  • Memory
  • Noninvasive Brain Stimulation

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • 1-day patterned tACS — DEVICE
    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.
  • 3-day patterned tACS — DEVICE
    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.
  • 5-day patterned tACS — DEVICE
    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.
  • 1-day continuous tACS — DEVICE
    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.
  • 3-day continuous tACS — DEVICE
    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.
  • 5-day continuous tACS — DEVICE
    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.

Study Details

This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free approaches for Alzheimer's disease and related dementia (ADRD). We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen memory-supporting networks.

Key Dates

First listed
Mar 10, 2026
Start date
Jun 1, 2026
Status verified
Jul 2026
Primary completion
Jan 31, 2031
Completion
Jan 31, 2031

Study Design

Enrollment
240 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: 1-day patterned tACS
  • Experimental: 3-day patterned tACS
  • Experimental: 5-day patterned tACS
  • Experimental: 1-day continuous tACS
  • Experimental: 3-day continuous tACS
  • Experimental: 5-day continuous tACS

Primary Outcome Measure

Visual working memory capacity measured behaviorally [ Time Frame: Baseline, 1-week after intervention, 1-month after intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
111 Cummington MallBostonMassachusetts02215
Robert Reinhart, PhD
[email protected]
617-353-9481

Find similar trials in Boston, MA

By research site
111 Cummington Mall· Boston, MA

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