Efficacy of L-menthol on Breathlessness in Asthma

Conditions

• Asthma

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• L-menthol — DRUG
  (Sigma-Aldrich, St. Louis, US)
• Placebo — OTHER
  Strawberry scent (Sigma-Aldrich, St. Louis, US)

Study Details

The purpose of this study is to assess the effect of L-menthol on breathlessness and exercise capacity in patients with Asthma.

Key Dates

First listed

Mar 30, 2026

Start date

May 7, 2026

Status verified

Aug 2026

Primary completion

Apr 30, 2027

Completion

May 31, 2027

Study Design

Enrollment

20 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: L-menthol
  In the trial, prior to performing submaximal cardio-pulmonary exercise testing (CPET), participants will be administered, L-menthol patch which will be attached to the inside of a facemask that is connected to the breathing circuit.
• Placebo Comparator: Placebo
  For placebo, the patch will contain a similarly patch with strawberry scent.

Primary Outcome Measure

Breathlessness intensity [ Time Frame: During submaximal test, at isotime during day 2 and day 3. ]

Central Contacts

• Zainab Ahmadi, MD, PhD
  046171000
  [email protected]

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