Evacuation Time and Tourniquet Use as Risk Factors for PTSD in Combat-Related Amputation

Sponsor
Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Study ID
NCT07502313
Status
Not Yet Recruiting

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Conditions

  • Amputation
  • Combat Posttraumatic Stess Disorder
  • Combat Trauma
  • PTSD

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Study Details

This study aims to evaluate the relationship between evacuation time, tourniquet use, and the development of post-traumatic stress disorder (PTSD) in patients with combat-related amputations. In the context of modern warfare, prolonged evacuation times and extended tourniquet application may contribute not only to physical injury but also to psychological trauma. The study will prospectively follow patients over 18 months to identify key predictors of PTSD and to assess their interaction.

Key Dates

First listed
Mar 30, 2026
Start date
Mar 15, 2026
Status verified
Mar 2026
Primary completion
Nov 15, 2026
Completion
Nov 15, 2026

Study Design

Enrollment
300 participants (estimated)

Arms

  • Arm: Combat-Related Amputation Cohort
    Participants in this cohort are Ukrainian veterans with combat-related single-limb amputations who are undergoing rehabilitation within the Superhumans Center network. All participants are enrolled within 2-4 months following injury and are followed prospectively for 18 months. This is an observational study with no interventional treatment assigned. The primary exposures of interest are evacuation time and duration of tourniquet use, obtained from medical records. Participants undergo structured psychological assessment using validated instruments, including the PTSD Checklist for DSM-5 (PCL-5), at predefined time points during rehabilitation and follow-up. The study aims to evaluate the association between these exposure variables and the development and progression of post-traumatic stress disorder (PTSD), as well as to assess their combined and interaction effects on psychological outcomes.

Primary Outcome Measure

PTSD severity measured by PCL-5 score [ Time Frame: 18 months (baseline, 2, 6, 12, and 18 months follow-up) ]

Central Contacts

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