MCE Molecular Imaging for Myocarditis

Part of paid clinical trials in Charlottesville, Virginia.

Sponsor
University of Virginia
Study ID
NCT07538544
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Myocarditis Acute

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Myocardial contrast echocardiography molecular imaging for inflammation — DIAGNOSTIC_TEST
    Myocardial contrast echocardiography (ultrasound of the heart) using an ultrasound contrast agent (Sonazoid, GE Healthcare) that contains phosphatidylserine, thereby targeting it to leukocytes and activated endothelium.

Study Details

Inflammation of the heart (myocarditis) is a serious condition that can cause heart failure, abnormal heart rhythms, cardiac arrest, and death. Rapid diagnosis of this condition is key to reversing it. The purpose of this study is to determine whether myocarditis such as that which occurs with viral illness, autoimmune conditions, or certain therapies (i.e. immune checkpoint inhibitors) can be diagnosed using a new form of ultrasound imaging of the heart (echocardiography) that uses a contrast agent that is targeted to inflammation (Sonazoid).

Key Dates

First listed
Apr 20, 2026
Start date
Sep 15, 2026
Status verified
Aug 2026
Primary completion
Jun 30, 2030
Completion
Jul 1, 2030

Study Design

Enrollment
30 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Patients with suspected Myocarditis
    Patients with any degree of suspicion for myocarditis based on symptoms, lab tests, ECG, or imaging tests.

Primary Outcome Measure

Diagnostic accuracy for presence/absence of Myocarditis [ Time Frame: 3 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of VirginiaCharlottesvilleVirginia22903
Jonathan Lindner, MD
[email protected]
14342979442

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By research site
University of Virginia· Charlottesville, VA

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