Effect of Osteopathic Intervention on Migraine

Sponsor
Escola Superior de Tecnologia da Saúde do Porto
Study ID
NCT07542340
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • Osteopathic Intervention Protocol — OTHER
    Starting by locating the C2 segment with the metacarpophalangeal joint of the second finger, whilst the other hand rested on the participant's face, homolateral inclination and contralateral rotation were induced, applying a thrust directed into rotation. In this phase, two attempts were made on each side, starting with the right side. In the second phase, the suboccipital inhibition technique was performed in the occipital region, using contact with the thenar and hypothenar eminences, positioning the distal metacarpophalangeal joints at the level of the superior nuchal line, over the suboccipital musculature, promoting gentle pressure towards the ceiling, associated with cephalic traction, lasting for three minutes.
  • Placebo technique — OTHER
    The researcher was positioned at the head of the table, making bilateral contact with the acromioclavicular joint and maintaining this position for 3 minutes, assisted by a stopwatch.

Study Details

Migraine is a common, disabling neurological condition characterized by severe, often unilateral pain accompanied by sensory symptoms like nausea and photophobia. Its pathophysiology involves activation of the trigeminovascular system, neuro-inflammation, and nervous system sensitisation. Due to the convergence of trigeminal and cervical nerves in the upper neck (C2), manual therapy may influence migraine symptoms. Osteopathic techniques, such as suboccipital inhibition and C2 manipulation, aim to reduce pain intensity and frequency by normalising mobility and reducing nociceptive stimulation. While promising, further research is needed to validate these interventions through rigorous clinical trials.

Key Dates

First listed
Apr 21, 2026
Start date
Jun 30, 2026
Status verified
Apr 2026
Primary completion
Aug 31, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
45 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Control group
    In the control group, bilateral contact of the acromioclavicular joint was performed.
  • Experimental: Experimental group
    The intervention consisted of two phases: a structural technique involving a high-velocity, low-amplitude thrust on segment C2 (Tixa \& Ebenegger, 2016), followed by a functional suboccipital inhibition technique (Chamtepie \& Pérot, 2008).

Primary Outcome Measure

Headache Impact Test [ Time Frame: Two weeks after the third intervention ]

Central Contacts

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