Pleural Effusion Types in Chronic Kidney Disease

Sponsor
Assiut University
Study ID
NCT07547852
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The purpose of this observational study is to understand the causes of pleural effusion (a buildup of fluid around the lungs) in patients with advanced Chronic Kidney Disease (CKD Stages 3 to 5). Pleural effusion is a common complication in kidney disease, but it can be caused by many different issues, such as simple fluid overload, heart failure, or infections like tuberculosis. To treat this fluid buildup effectively, doctors need to classify whether the fluid is a transudate (usually caused by pressure imbalances like fluid overload) or an exudate (caused by inflammation, lung disease, or infection). Standard medical formulas, known as Light's Criteria, are typically used to figure this out by comparing proteins in the fluid to proteins in the blood. However, these standard tests may sometimes misclassify the fluid in kidney disease patients because their baseline blood protein and albumin levels are often altered by their condition. Researchers in this study will enroll adult CKD patients (both on dialysis and not yet on dialysis) who have confirmed fluid around their lungs. Participants will undergo a standard, ultrasound-guided procedure called a diagnostic thoracentesis to safely draw a small amount of the chest fluid. At the same time, a routine blood sample will be taken. The study aims to: * Compare the chest fluid to the blood sample using standard criteria, abbreviated criteria, and the Serum-Pleural Effusion Albumin Gradient (SPAG). * Determine the most common underlying causes of lung fluid across different stages of kidney disease. * Identify which diagnostic formula is the most accurate for CKD patients, helping doctors avoid misdiagnosis and provide better, more targeted treatments.

Key Dates

First listed
Apr 23, 2026
Start date
May 31, 2026
Status verified
Apr 2026
Primary completion
May 31, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: CKD Stage 3-5 with Pleural Effusion
    Adult patients (≥18 years old) with a confirmed diagnosis of Chronic Kidney Disease (CKD) Stages 3 through 5, including both pre-dialysis and dialysis-dependent patients, who present with a radiologically confirmed pleural effusion. Patients in this cohort will undergo an ultrasound-guided diagnostic thoracentesis alongside simultaneous serum laboratory testing. The collected pleural fluid and serum will be analyzed to classify the effusion (using Light's Criteria, abbreviated criteria, and SPAG) and to determine its underlying etiology.

Primary Outcome Measure

Number of Participants Classified with Transudative or Exudative Pleural Effusions [ Time Frame: Baseline (at the time of diagnostic thoracentesis) ]

Find similar trials

Nationwide
Chronic kidney disease trialsNephrology trialsKidney disease trials

Related Studies