Cf-PWV and TyG Index Study

Sponsor
Hospital de Base
Study ID
NCT07589374
Status
Not Yet Recruiting

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Conditions

  • Arterial Stiffness
  • Blood Pressure Variability
  • Cardiovascular Risk
  • Hypertension
  • Insulin Resistance Syndrome

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Study Details

This study aims to investigate how metabolic health is related to arterial stiffness and daily blood pressure patterns. High blood pressure is one of the leading causes of heart disease worldwide, but cardiovascular risk is not determined only by average blood pressure values. Changes in blood vessel structure and metabolic function also play an important role in the development of cardiovascular disease. Arterial stiffness reflects how flexible or rigid the arteries are. It can be measured using carotid-femoral pulse wave velocity (cf-PWV), which is considered a reliable and widely used method to assess vascular health. Increased arterial stiffness is associated with aging and higher cardiovascular risk. At the same time, metabolic factors such as insulin resistance and central obesity are strongly linked to vascular damage. The triglyceride-glucose (TyG) index is a simple measure derived from routine blood tests and has been shown to reflect insulin resistance. Additional derived indices that combine TyG with body measurements (such as waist circumference and body mass index) may provide an even more comprehensive evaluation of metabolic risk. Another important aspect of cardiovascular regulation is how blood pressure changes throughout the day. Blood pressure naturally rises in the morning after waking, a phenomenon known as the morning blood pressure surge. When this increase is excessive, it has been associated with a higher risk of cardiovascular events such as stroke and heart attack. This study will evaluate the relationship between metabolic indices, arterial stiffness, and morning blood pressure patterns in adults undergoing ambulatory blood pressure monitoring as part of routine clinical care. The study will include both previously collected data and new participants evaluated using standardized methods. No additional interventions will be performed, and all data will be collected as part of routine clinical evaluation. The results of this study may help improve cardiovascular risk assessment by integrating simple metabolic markers with vascular measurements and daily blood pressure behavior, potentially allowing earlier identification of individuals at higher risk.

Key Dates

First listed
May 15, 2026
Start date
Jul 1, 2026
Status verified
Apr 2026
Primary completion
Jul 1, 2027
Completion
Jul 1, 2028

Study Design

Enrollment
800 participants (estimated)

Arms

  • Arm: Normotensive participants
    Adults with normal 24-hour blood pressure based on ABPM (\< 130/80 mmHg)
  • Arm: Untreated hypertensive participants
    Adults with elevated 24-hour blood pressure (≥130/80 mmHg) not receiving antihypertensive treatment.

Primary Outcome Measure

Carotid-femoral pulse wave velocity (cf-PWV) [ Time Frame: Baseline ]

Central Contacts

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