Comparison of CT and MR (VI-RADS) Imaging for Local Bladder Cancer Staging

Sponsor
Oslo University Hospital
Study ID
NCT07602010
Status
Recruiting
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Conditions

  • Bladder Cancer
  • Muscle Invasive Bladder Cancer (MIBC)
  • Non Muscle Invasive Bladder Cancer
  • Urothelial Carcinoma (UC)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

This prospective diagnostic accuracy study compares computed tomography (CT) and multiparametric magnetic resonance imaging (MRI) using the Vesical Imaging-Reporting and Data System (VI-RADS) for local staging of newly diagnosed bladder cancer. All participants undergo both imaging modalities prior to transurethral resection of the bladder tumor (TURBT) or cystectomy. Histopathology serves as the reference standard.

Key Dates

First listed
May 22, 2026
Start date
Apr 22, 2026
Status verified
May 2026
Primary completion
Apr 30, 2028
Completion
Oct 31, 2028

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: Imaging Comparison Group
    All participants undergo contrast-enhanced CT and multiparametric MRI (VI-RADS) as part of routine diagnostic work-up prior to transurethral resection of the bladder tumor or cystectomy. Imaging findings are compared with histopathology for assessment of diagnostic accuracy.

Primary Outcome Measure

Diagnostic Accuracy for Detection of Muscle-Invasive Bladder Cancer (≥T2) [ Time Frame: From imaging to final histopathological reference standard (up to 12 months) ]

Central Contacts

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