MAP- Versus Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery

Sponsor
Ankara Etlik City Hospital
Study ID
NCT07609680
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Mean Arterial Pressure-Guided Hemodynamic Management — PROCEDURE
    Intraoperative hemodynamic management will be performed according to predefined mean arterial pressure targets during colorectal surgery. Standard anesthetic care, fluid therapy, vasopressor use, and intraoperative monitoring will be applied according to institutional clinical practice.
  • Cardiac Index-Guided Hemodynamic Management — PROCEDURE
    Intraoperative hemodynamic management will be performed according to predefined cardiac index targets during colorectal surgery. Cardiac index values will be monitored intraoperatively, and fluid therapy, vasopressor use, and inotrope administration will be adjusted according to the hemodynamic status of the patient and institutional clinical practice.

Study Details

This prospective randomized trial aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing colorectal surgery. Patients will be randomly assigned to receive either mean arterial pressure-guided or cardiac index-guided intraoperative hemodynamic management. Colorectal surgery is a major abdominal procedure associated with prolonged operative times, significant fluid shifts, blood loss, and hemodynamic instability. These factors can contribute to impaired renal perfusion and subsequent postoperative renal dysfunction. Although mean arterial pressure is widely used to guide intraoperative hemodynamic management, blood pressure alone may not adequately reflect systemic blood flow or regional tissue perfusion. Cardiac index-guided management may provide a more direct assessment of global circulatory adequacy. The primary outcome of the study is the change in serum creatinine levels from the preoperative baseline to 72 hours postoperatively. Secondary outcomes include intraoperative hemodynamic variables, fluid and vasopressor requirements, urine output, postoperative renal function parameters, intensive care unit (ICU) and hospital length of stay, and 30-day mortality.

Key Dates

First listed
May 27, 2026
Start date
Jun 2, 2026
Status verified
Jun 2026
Primary completion
Dec 14, 2027
Completion
Dec 28, 2027

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Mean Arterial Pressure-Guided Hemodynamic Management
    Patients in this group will receive intraoperative hemodynamic management based on predefined mean arterial pressure targets. Hemodynamic interventions, including fluid administration, vasopressor therapy, and other standard intraoperative management strategies, will be guided primarily by mean arterial pressure values
  • Active Comparator: Cardiac Index-Guided Hemodynamic Management
    Patients in this group will receive intraoperative hemodynamic management based on predefined cardiac index targets. Hemodynamic interventions, including fluid administration, vasopressor or inotrope therapy, and other standard intraoperative management strategies, will be guided primarily by cardiac index values.

Primary Outcome Measure

Change in serum creatinine level from baseline to postoperative 72 hours [ Time Frame: : Preoperative baseline and postoperative 72nd hour ]

Central Contacts

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