Colorectal cancer Clinical Trials

Recruiting colorectal cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat colorectal cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting colorectal cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting colorectal cancer trials

Within

The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp

for Shared Decision Making

Sponsor: Vejle Hospital

Sex: All·Age: 18+

Code: NCT05776381·Phase 2

Reducing Neoplasia Recurrence After Non-thermal Endoscopic Resection of Large Colorectal Polyps

for Colorectal Cancer

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 18+

Code: NCT07242820

Increasing CRC Screening in Community Health Centers Through Mobile Messaging Optimization

for Colorectal Cancer

4 sites incl. Boston

Sponsor: University of Colorado, Denver

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07569250

Novel Couple-Based Mindfulness Intervention for Metastatic Colorectal Cancer

for Colorectal Cancer

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07759921

Apply to this trial

Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer

for Colon Polyp

2 sites incl. Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 40 - 80

Code: NCT07790718

Apply to this trial

A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation

for Ovarian Cancer

Sponsor: LG Chem

Sex: All·Age: 18+

Code: NCT07752875·Phase 1, Phase 2

CPHARM - CRC Study

for Colorectal Cancer

Sponsor: Monash University Malaysia

Sex: All·Age: 50 - 75·Accepts healthy volunteers

Code: NCT07714291

IKS04 Regimen in Advanced Solid Tumors That Express CA242

for Colorectal Cancer

4 sites incl. Los Angeles

Sponsor: Iksuda Therapeutics Ltd.

Sex: All·Age: 18+

Code: NCT07738939·Phase 1

Tucatinib Continuation Study

for HER2-positive Breast Cancer

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07768358·Phase 4

Study to Evaluate the Diagnostic Performance of GEH300079 (68Ga) Injection PET/CT for Detection of PC in Patients With Colorectal, Gastric, Ovarian, or Pancreatic Cancers (PERISCOPE)

for Colorectal Cancer

1 site in Grand Rapids

Sponsor: GE Healthcare

Sex: All·Age: 18+

Code: NCT07219238·Phase 2, Phase 3

Apply to this trial

Transanal Irrigation for the Management of Early Low Anterior Resection Syndrome (LARS)

for Colorectal Cancer

1 site in Weston

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07219745

Researching the Effect of Exercise on Cancer

for Breast Cancer

2 sites incl. Durate

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04589468

Apply to this trial

A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.

for Imaging

Sponsor: Radiopharm Theranostics, Ltd

Sex: All·Age: 18+

Code: NCT07272642·Phase 1

Preventing Early-Onset Colorectal Cancer in the VA

for Colorectal Neoplasms

1 site in New York

Sponsor: VA Office of Research and Development

Sex: All·Age: 45 - 49·Accepts healthy volunteers

Code: NCT07071454

Evaluation of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for Detection and Optical Characterization of Colorectal Lesions: A Prospective Randomized Controlled Study

for Colorectal Neoplasms

Sponsor: Alexandre Vontobel Padoin

Sex: All·Age: 18+

Code: NCT07797361

Colorectal Cancer Screening in the Homeless

for Colorectal Cancer

1 site in Washington D.C.

Sponsor: George Washington University

Sex: All·Age: 45 - 75

Code: NCT07220018

A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial Cancers

for Triple Negative Breast Cancer (TNBC)

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT07545122·Phase 1

Apply to this trial

Nutritional Supplementation to Improve Colorectal Cancer Surgery

for Colorectal Cancer

Sponsor: Istituto Clinico Humanitas

Sex: All·Age: 18+

Code: NCT07599501

Mind-Body Interventions for the Improvement of Quality of Life, Stress, and Sleep Quality Among Survivors of Breast, Prostate, Endometrial, or Colorectal Cancer

for Breast Cancer Stage I

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT07745023

Increasing Breast and Colorectal Cancer Screening in the Community

for Colorectal Neoplasms

7 sites in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: Female·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07748377

Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing Outreach

for Colorectal Cancer (CRC) Screening

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07781774

Anti-EGFR Agents in Patients With Right-sided Advanced Colorectal Cancer With Wild-type RAS and AREG/EREG High Status

for Colorectal Cancer

Sponsor: Gruppo Oncologico del Nord-Ovest

Sex: All·Age: 18+

Code: NCT07094893·Phase 4

Assessment of Adherence to Remotely Monitored Physical Activity Tracked on a Smartwatch, and Its Impact on Reducing Fatigue 3 Months After Adjuvant Chemotherapy for Cancer

for Breast Cancer

Sponsor: Centre Antoine Lacassagne

Sex: All·Age: 18 - 75

Code: NCT07429487

Study of Petosemtamab Plus Chemotherapy Versus Cetuximab or Bevacizumab Plus Chemotherapy in RAS and BRAF Wild Type, Recurrent, Unresectable or Metastatic Colorectal Cancer (LiGeR-CRC2)

for Colorectal Cancer

Sponsor: Genmab

Sex: All·Age: 18+

Code: NCT07775287·Phase 3

Apply to this trial

Colon Health Champion Program

for Colorectal Cancer

1 site in Richmond

Sponsor: Virginia Commonwealth University

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07796334

Natural History Study of Early Life Exposures in Agriculture (ELEA)

for Prostate Cancer

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07328516

Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy

for Colorectal Neoplasms

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07715903·Phase 1

The PharmFIT Study

for Colorectal Cancer

2 sites incl. Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06656936

NOMAD-GI: Molecular-guided Non-operative Management and Organ Preservation Strategy After Precision Therapy in Gastrointestinal Cancers

for Gastrointestinal Cancer

Sponsor: Peking University Cancer Hospital & Institute

Sex: All·Age: 18+

Code: NCT07775859

Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer

for Bladder Cancer

3 sites incl. Boston

Sponsor: Lumina Pharmaceuticals Inc

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07781852·EARLY_Phase 1

Advocacy, Partnership, Outreach, and Yielding Optimized Care for Oncology Patients

for Colorectal Cancer

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07403981

Allogeneic NK Cell Therapy Combined With Standard Maintenance Treatment in Advanced Solid Tumors

for NSCLC (Advanced Non-small Cell Lung Cancer)

Sponsor: BOE Technology Group Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07551778·Phase 1, Phase 2

TCR1188-ABC Cells in KRAS-mutated Cancers

for Cholangiocarcinoma

1 site in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07594067·Phase 1

Apply to this trial

Tovecimig Plus FOLFIRI in Second Line Metastatic Colorectal Cancer

for Colorectal Cancer

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07662031·Phase 2

A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer

for Colorectal Cancer

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07691489·Phase 2

A Study Comparing BL-M07D1 With Physician's Choice Therapy in Patients With HER2 IHC3+ Advanced Colorectal Cancer Who Failed Prior Treatment With Oxaliplatin, Fluorouracil and Irinotecan

for Colorectal Cancer

Sponsor: Sichuan Baili Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07730489·Phase 3

A Study of IOV-5001 in Adults With Advanced Solid Tumors

for Advanced Solid Tumors

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT07743723·Phase 1, Phase 2

Implementation Of A Telesurgery Program At A Referral Center For Robotic Surgery

for Prostate Cancer

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07792109

Colorectal Omics and ofCS Proteoglycans (COCO) in Screening and a Diagnostic Pathway

for Colorectal Cancer

Sponsor: Nordsjaellands Hospital

Sex: All·Age: 18+

Code: NCT07237984

Apply to this trial

Zanzalintinib Alone or in Combination With Pembrolizumab and Berahyaluronidase Alfa in Participants With Colorectal Cancer With Molecular Residual Disease

for Colorectal Cancer

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT07750158·Phase 3

Prospective Assessment of Alignment Between Multimodal Artificial Intelligence and Multidisciplinary Team Decisions in Gastrointestinal Oncology

for Gastric Cancer

Sponsor: Shanghai Minimally Invasive Surgery Center

Sex: All·Age: 18+

Code: NCT07746830

Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients

for Oesophageal Cancer

Sponsor: University of Cologne

Sex: All·Age: 18+

Code: NCT06414122

Triton 1.5 Robotic System for Diagnostic Colonoscopy

for Colonoscopy

Sponsor: Neptune Medical

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT07606963

SAMe in Prevention of Oxaliplatin-associated Liver Injury

for Colorectal Cancer

2 sites in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT06258525·Phase 2

Liver-directed Chemotherapy After Surgery of Liver Metastases of Colorectal Cancer in Patients With High Risk of Recurrence of Their Disease

for Colorectal Adenocarcinoma Metastatic in the Liver

Sponsor: UNICANCER

Sex: All·Age: 18+

Code: NCT07284394·Phase 3

A Study of CLSP 5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors (SENTINEL-101)

for Advanced Solid Tumor

4 sites incl. Durham

Sponsor: Clasp Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07650357·Phase 1

A Clinical Study of TQB2930 Injection and Chemotherapy With or Without Bevacizumab in the Treatment of Advanced Colorectal Cancer

for Colorectal Cancer

Sponsor: Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07653685·Phase 1, Phase 2

Disease Evolution and Risk Factors of AIDS-related Prevalent Cancers

for HIV (Human Immunodeficiency Virus)

Sponsor: Shenzhen Third People's Hospital

Sex: All·Age: 18+

Code: NCT07696169

IBI363 Combined With Bevacizumab for Advanced Colorectal Cancer

for Colorectal Cancer

Sponsor: Innovent Biologics (Suzhou) Co. Ltd.

Sex: All·Age: 18+

Code: NCT07722494·Phase 3

Apply to this trial

Long-Term Extension Study for Participants Previously Enrolled in an Exelixis-Sponsored Study

for Cancer

2 sites incl. Bay Shore

Sponsor: Exelixis

Sex: All·Age: All ages

Code: NCT07620574·Phase 3

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer

for Colorectal Cancer

11 sites incl. Los Angeles

Sponsor: Verastem, Inc.

Sex: All·Age: 18+

Code: NCT07659795·Phase 2

Apply to this trial

Protective Role of Alpha-Lipoic Acid in Chemotherapy-Induced Mucositis

for Colorectal Cancer

Sponsor: Ain Shams University

Sex: All·Age: 18+

Code: NCT07736495·Phase 2, Phase 3

Apply to this trial

Guardant Shield Colorectal Cancer Screening

for Colorectal Cancer

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 45 - 85·Accepts healthy volunteers

Code: NCT07436637

Apply to this trial

Qigong Exercise for Muscles Strength and Quality of Life in Colorectal Cancer Patients Undergoing Chemotherapy

for Colorectal Cancer

Sponsor: Cairo University

Sex: All·Age: 35 - 55

Code: NCT07709429

A One-year Follow-up of Incisional Hernia Formation Between Device Assisted and Manual Laparotomy Closure

for Incisional Hernia After Midline Laparotomy

Sponsor: Suturion AB

Sex: All·Age: 18+

Code: NCT07766044

Apply to this trial

Evaluation of XYA02 in Patients With Advanced Solid Tumors

for MUC1-expressing Advanced, Relapsed and/or Refractory Solid Tumors

Sponsor: XYone Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT07670312·Phase 1, Phase 2

Development and Validation of a Colorectal Cancer Diagnostic Model

for Colorectal Cancer

Sponsor: Peking University Cancer Hospital & Institute

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07692555

Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal Cancer

for Colorectal Cancer

1 site in Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT07281768·Phase 2

Apply to this trial

SL-28 for Advanced Solid Tumours

for Head & Neck Cancer

Sponsor: Second Life Therapeutics

Sex: All·Age: 18+

Code: NCT07341737·Phase 1, Phase 2

Apply to this trial

GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer

for Pancreatic Cancer

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18 - 99

Code: NCT07627191·EARLY_Phase 1

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Colorectal cancer clinical trials — common questions

Are colorectal cancer clinical trials free to join?

Yes. Participating in a colorectal cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a colorectal cancer clinical trial?

Each colorectal cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a colorectal cancer trial near me?

Use the location controls above. We'll show recruiting colorectal cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many colorectal cancer trials are recruiting right now?

We're currently tracking roughly 238 recruiting colorectal cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Colorectal cancer trials by city

Los Angeles, CA Duarte, CA Boston, MA Birmingham, AL Aurora, CO Denver, CO La Jolla, CA San Francisco, CA Orange, CA San Diego, CA Miami, FL Ann Arbor, MI

Related specialties

Oncology GI oncology