Colorectal cancer Clinical Trials

Recruiting colorectal cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat colorectal cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting colorectal cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting colorectal cancer trials

Within

The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp

for Shared Decision Making

Sponsor: Vejle Hospital

Sex: All·Age: 18+

Code: NCT05776381·Phase 2

Increasing CRC Screening in Community Health Centers Through Mobile Messaging Optimization

for Colorectal Cancer

4 sites incl. Boston

Sponsor: University of Colorado, Denver

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07569250

CPHARM - CRC Study

for Colorectal Cancer

Sponsor: Monash University Malaysia

Sex: All·Age: 50 - 75·Accepts healthy volunteers

Code: NCT07714291

Study to Evaluate the Diagnostic Performance of GEH300079 (68Ga) Injection PET/CT for Detection of PC in Patients With Colorectal, Gastric, Ovarian, or Pancreatic Cancers (PERISCOPE)

for Colorectal Cancer

1 site in Grand Rapids

Sponsor: GE Healthcare

Sex: All·Age: 18+

Code: NCT07219238·Phase 2, Phase 3

Apply to this trial

Transanal Irrigation for the Management of Early Low Anterior Resection Syndrome (LARS)

for Colorectal Cancer

1 site in Weston

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07219745

A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial Cancers

for Triple Negative Breast Cancer (TNBC)

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT07545122·Phase 1

Nutritional Supplementation to Improve Colorectal Cancer Surgery

for Colorectal Cancer

Sponsor: Istituto Clinico Humanitas

Sex: All·Age: 18+

Code: NCT07599501

Allogeneic NK Cell Therapy Combined With Standard Maintenance Treatment in Advanced Solid Tumors

for NSCLC (Advanced Non-small Cell Lung Cancer)

Sponsor: BOE Technology Group Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07551778·Phase 1, Phase 2

Tovecimig Plus FOLFIRI in Second Line Metastatic Colorectal Cancer

for Colorectal Cancer

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07662031·Phase 2

A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer

for Colorectal Cancer

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07691489·Phase 2

Triton 1.5 Robotic System for Diagnostic Colonoscopy

for Colonoscopy

Sponsor: Neptune Medical

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT07606963

SAMe in Prevention of Oxaliplatin-associated Liver Injury

for Colorectal Cancer

2 sites in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT06258525·Phase 2

Colorectal Cancer Screening in the Homeless

for Colorectal Cancer

1 site in Washington D.C.

Sponsor: George Washington University

Sex: All·Age: 45 - 75

Code: NCT07220018

Liver-directed Chemotherapy After Surgery of Liver Metastases of Colorectal Cancer in Patients With High Risk of Recurrence of Their Disease

for Colorectal Adenocarcinoma Metastatic in the Liver

Sponsor: UNICANCER

Sex: All·Age: 18+

Code: NCT07284394·Phase 3

Advocacy, Partnership, Outreach, and Yielding Optimized Care for Oncology Patients

for Colorectal Cancer

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07403981

TCR1188-ABC Cells in KRAS-mutated Cancers

for Cholangiocarcinoma

1 site in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07594067·Phase 1

Apply to this trial

A Study of CLSP 5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors (SENTINEL-101)

for Advanced Solid Tumor

4 sites incl. Durham

Sponsor: Clasp Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07650357·Phase 1

A Clinical Study of TQB2930 Injection and Chemotherapy With or Without Bevacizumab in the Treatment of Advanced Colorectal Cancer

for Colorectal Cancer

Sponsor: Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07653685·Phase 1, Phase 2

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer

for Colorectal Cancer

5 sites incl. Los Angeles

Sponsor: Verastem, Inc.

Sex: All·Age: 18+

Code: NCT07659795·Phase 2

Apply to this trial

Disease Evolution and Risk Factors of AIDS-related Prevalent Cancers

for HIV (Human Immunodeficiency Virus)

Sponsor: Shenzhen Third People's Hospital

Sex: All·Age: 18+

Code: NCT07696169

Natural History Study of Early Life Exposures in Agriculture (ELEA)

for Prostate Cancer

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07328516

Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy

for Colorectal Neoplasms

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07715903·Phase 1

Qigong Exercise for Muscles Strength and Quality of Life in Colorectal Cancer Patients Undergoing Chemotherapy

for Colorectal Cancer

Sponsor: Cairo University

Sex: All·Age: 35 - 55

Code: NCT07709429

Evaluation of XYA02 in Patients With Advanced Solid Tumors

for MUC1-expressing Advanced, Relapsed and/or Refractory Solid Tumors

Sponsor: XYone Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT07670312·Phase 1, Phase 2

Development and Validation of a Colorectal Cancer Diagnostic Model

for Colorectal Cancer

Sponsor: Peking University Cancer Hospital & Institute

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07692555

Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal Cancer

for Colorectal Cancer

1 site in Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT07281768·Phase 2

Apply to this trial

SL-28 for Advanced Solid Tumours

for Head & Neck Cancer

Sponsor: Second Life Therapeutics

Sex: All·Age: 18+

Code: NCT07341737·Phase 1, Phase 2

Apply to this trial

GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer

for Pancreatic Cancer

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18 - 99

Code: NCT07627191·EARLY_Phase 1

The PharmFIT Study

for Colorectal Cancer

2 sites incl. Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06656936

Preventing Early-Onset Colorectal Cancer in the VA

for Colorectal Neoplasms

1 site in New York

Sponsor: VA Office of Research and Development

Sex: All·Age: 45 - 49·Accepts healthy volunteers

Code: NCT07071454

Exploratory Clinical Evaluation of Personalized Functional Profiling in GI Tumors: Predicting Drug Response in CRC and PDAC

for Colorectal Cancer

Sponsor: Luxembourg Institute of Health

Sex: All·Age: 18+

Code: NCT07500259

Development of a New Simplified Tool to Predict LNPCPs Histology and Assess the Risk of Submucosal Invasive Cancer. The Colorectal Regular-Irregular Score

for Colorectal Cancer

Sponsor: University Hospital, Ghent

Sex: All·Age: 18+

Code: NCT07584486

A Study of [177Lu]Lu-A9-0631 and [225Ac]Ac-A9-0642 With [68Ga]Ga-A9-6217 or [177Lu]Lu-A9-0631 Imaging in GRPR+ Solid Tumors

for Breast Cancer

Sponsor: Alpha-9 Oncology USA Inc.

Sex: All·Age: 18+

Code: NCT07661641·Phase 1

Apply to this trial

The Correlation of Postoperative Polyp Recurrence and Colorectal Cancer

for Colorectal Cancer

Sponsor: Gansu Provincial Hospital

Sex: All·Age: 18 - 80

Code: NCT07708415

Effect of Video Training on Patients' Self-Efficacy After Colorectal Surgery

for Colorectal Cancer

Sponsor: Ankara Yildirim Beyazıt University

Sex: All·Age: 18 - 65

Code: NCT07078656

Optimizing Patient Treatment With EPA-enriched Nutrition, a Randomised Control Trial

for Malnutrition (Calorie)

Sponsor: University of Edinburgh

Sex: All·Age: 18+

Code: NCT07255066

Optimising Colorectal Cancer Patient Pathways

for Colorectal Cancer

Sponsor: University of Edinburgh

Sex: All·Age: 18+

Code: NCT07430540

Guardant Shield Colorectal Cancer Screening

for Colorectal Cancer

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 45 - 85·Accepts healthy volunteers

Code: NCT07436637

A First-in-Human Study of HH160 in Patients With Advanced Solid Tumors

for Solid Tumor

Sponsor: Huahui Health

Sex: All·Age: 18 - 75

Code: NCT07623369·Phase 1

A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

for Advanced Solid Tumor

1 site in Fairfax

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT07629960·Phase 1, Phase 2

Apply to this trial

Precision Navigation to Improve Community Cancer Screening Participation

for Cancer Screening

Sponsor: Hunan Cancer Hospital

Sex: All·Age: 45 - 74·Accepts healthy volunteers

Code: NCT07676383

[68Ga]BED003 PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications

for Colorectal Cancer

Sponsor: Blue Earth Diagnostics

Sex: All·Age: 18 - 79

Code: NCT07702292·Phase 2

Apply to this trial

Evaluation of Skin Tests in Biotherapy Allergies

for Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

Sponsor: University Hospital, Angers

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06971848

Apply to this trial

Liquid Biopsy in Early Colorectal Lesions

for Colorectal Neoplasms

Sponsor: University Hospital, Montpellier

Sex: All·Age: 18+

Code: NCT07319104

Assessment of Adherence to Remotely Monitored Physical Activity Tracked on a Smartwatch, and Its Impact on Reducing Fatigue 3 Months After Adjuvant Chemotherapy for Cancer

for Breast Cancer

Sponsor: Centre Antoine Lacassagne

Sex: All·Age: 18 - 75

Code: NCT07429487

An Exploratory Study of Zanidatamab in HER2-positive Advanced Tumor After at Least One Line of Standard Therapy

for Neoplasms

Sponsor: Haihua Yuan

Sex: All·Age: 18+

Code: NCT07631871·Phase 2

Exploratory Study on the Efficacy and Safety of Trastuzumab Rezetecan in the Treatment of HER2-Expressiong Advanced Solid Tumor

for Solid Tumors

Sponsor: Haihua Yuan

Sex: All·Age: 18+

Code: NCT07631884·Phase 2

Health Behavior Intervention for Colorectal Cancer Patients

for Colorectal Cancer

Sponsor: Nanjing Medical University

Sex: All·Age: 18 - 75

Code: NCT07632313

A Study of a Urine Test to Detect Colorectal Cancer

for Colorectal Cancer

1 site in New York

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07649057

Apply to this trial

Oral, Fecal and Intratumoral Microbiome Atlas in Colombian Patients With Advanced Solid Tumors Receiving First-Line Immunotherapy

for Gastric Cancer

Sponsor: Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07676461

Apply to this trial

Nudging Preventive Screening Via Message Framing and Bundling

for Breast Neoplasms

Sponsor: University of Chile

Sex: All·Age: 21 - 74

Code: NCT07644910

MAP- Versus Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery

for Colorectal Cancer

Sponsor: Ankara Etlik City Hospital

Sex: All·Age: 18 - 80

Code: NCT07609680

Apply to this trial

A Phase II Study of GV20-0251 in Combination With Anti-PD-1 Monoclonal Antibodies in Patients With Unresectable, Locally Advanced, or Metastatic Solid Tumors.

for Uterine Cervical Neoplasms

Sponsor: GV20 Therapeutics

Sex: All·Age: 18 - 80

Code: NCT07623642·Phase 2

SBRT Followed by PD-1 Inhibitor, Bevacizumab and TAS-102 as Third-Line Therapy for Recurrent/Metastatic Colorectal Cancer

for Colorectal Neoplasms

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18 - 75

Code: NCT07535632·Phase 2

Prediction of Peritoneal Dissemination of Digestive Tumors Through the Study of Circulating Tumor DNA

for Gastric Cancer (GC)

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07574957

A Prospective Study of a Subharmonic-Aided Pressure Estimate Technology for Early Prediction of Response to Systemic Therapy in Colorectal Cancer Liver Metastases

for Colorectal Liver Metastasis

Sponsor: The First Hospital of Jilin University

Sex: All·Age: 18+

Code: NCT07583381

Comparing Efficacy and Safety of Enlituo® Versus Erbitux® Plus FOLFOX in Locally Advanced/Metastatic Colorectal Cancer With RAS/BRAF Wild-type and MSS/pMMR Status.

for Colorectal Cancer

Sponsor: Taizhou Mabtech Pharmaceutical Co.,Ltd

Sex: All·Age: 18+

Code: NCT07595276·Phase 3

The Implementation of Genetic Risk for Colorectal Cancer Screening

for Colorectal Cancer

1 site in Evanston

Sponsor: Endeavor Health

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07621757

Transversus Abdominis Plane and Rectus Sheath Block for Robotic Colectomy

for Rectus Sheath Block

Sponsor: Tri-Service General Hospital (TSGH)

Sex: All·Age: 20 - 80

Code: NCT07624916·Phase 4

Glucose Homeostasis and Shared Genetic Factors in Colorectal Cancer

for Colorectal Cancer

Sponsor: Chang Gung Memorial Hospital

Sex: All·Age: 20 - 85

Code: NCT07648589

Colorectal cancer clinical trials — common questions

Are colorectal cancer clinical trials free to join?

Yes. Participating in a colorectal cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a colorectal cancer clinical trial?

Each colorectal cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a colorectal cancer trial near me?

Use the location controls above. We'll show recruiting colorectal cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many colorectal cancer trials are recruiting right now?

We're currently tracking roughly 238 recruiting colorectal cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Colorectal cancer trials by city

Los Angeles, CA Duarte, CA Boston, MA Denver, CO Aurora, CO Birmingham, AL La Jolla, CA San Francisco, CA Orange, CA San Diego, CA Miami, FL Sarasota, FL

Related specialties

Oncology GI oncology