Smart Discharges for Older Children

Part of paid clinical trials in San Francisco, California.

Sponsor
University of British Columbia
Study ID
NCT07629154
Status
Recruiting
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Conditions

  • Sepsis

Eligibility Criteria

Sex
ALL
Age
5 Years - 16 Years
Healthy Volunteers
Not accepted

Interventions

  • No Intervention: Observational Cohort — OTHER
    This is a non-interventional study

Study Details

This study is an observational multi-country cohort study that aims to build algorithms that can identify children between 5 and 16 years of age admitted for proven or suspected sepsis who are at risk of mortality after they are discharged in East Africa. In low- and middle-income countries, about 5% of children discharged after hospitalization for sepsis will die in the weeks after returning home. Doctors and parents are often unaware of this period of vulnerability and are poorly equipped to identify or handle this critical situation. This project builds on past work that developed and evaluated models and the Smart Discharges program to predict, during hospitalization, an individual child's risk of recurrent illness and mortality, as well as to provide additional post-discharge support to at-risk children. Participants will be enrolled from facilities once they are admitted, collecting clinical and social variables. They will then be followed until 6 months post-discharge to understand what happens to them after they return home. This data will be evaluated to identify which variables collected at facilities can be predictive of mortality and recurrent illness after discharge.

Key Dates

Start date
Jan 2, 2024
Status verified
Jun 2026
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
4,000 participants (estimated)

Arms

  • Arm: Pediatric patients 5-16 years of age
    Pediatric patients admitted to a study site with suspected or proven infection

Primary Outcome Measure

Post-discharge mortality [ Time Frame: Discharge until 6 months post-discharge ]

Central Contacts

Locations (3)

FacilityCityStateZIP
University of California, San FranciscoSan FranciscoCalifornia94117
Weill Cornell MedicineIthacaNew York14850
University of WashingtonSeattleWashington98195

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By research site
University of California, San Francisco· San Francisco, CAWeill Cornell Medicine· Ithaca, NYUniversity of Washington· Seattle, WA

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