End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest

Part of paid clinical trials in Oklahoma City, Oklahoma.

Sponsor
Office of the Medical Director for EMS in Oklahoma City and Tulsa
Study ID
NCT07632430
Status
Active Not Recruiting

Conditions

  • Cardiac Arrest, Out-Of-Hospital
  • End-Tidal Carbon Dioxide
  • Prehospital Emergency Medical Services
  • Prehospital Resuscitation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The investigators aim to assess the relationship between patient characteristics, prehospital treatments, and vital signs to determine if a threshold EtCO2 value, a change in EtCO2 value (final - initial), or a trend in EtCO2 (positive/negative) is a better predictor of patient survival to discharge. The secondary aim of this project is to identify significant predictors of neurologically intact patient survival as indicated by a cerebral performance category (CPC) score of 1-2.

Key Dates

Start date
Jan 1, 2024
Status verified
Jun 2026
Primary completion
Jul 1, 2025
Completion
Sep 30, 2026

Study Design

Enrollment
3,500 participants (estimated)

Arms

  • Arm: stable ETCO2
    low variation in measured end-tidal CO2 during cpr; low/high threshold yet to be determined
  • Arm: unstable/trending ETCO2
    variability in end-tidal CO2 during CPR, with or without measurable trend

Primary Outcome Measure

Survival to Hospital Discharge [ Time Frame: 90 days ]

Locations (1)

FacilityCityStateZIPSite coordinators
Office of the Medical Director of EMS for Metropolitan Oklahoma City and TulsaOklahoma CityOklahoma73135-

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By research site
Office of the Medical Director of EMS for Metropolitan Oklahoma City and Tulsa· Oklahoma City, OK

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