The Effect of Osteopathic Manipulative Techniques on Human Tear Composition

Conditions

• No Disease or Condition is Being Directly Studied
• The Focus of the Study in Healthy Volunteers

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Osteopathic Manipulative Treatment — OTHER
  Sequential Osteopathic Manipulative Treatment of suboccipital 4-step release, occipital mastoid suture release, and sphenopalatine ganglion release.
• Sham — OTHER
  Sham protocol including holding of the occiput and thoracic area and cranial vault hold without interaction with the motion.

Study Details

This is a pilot study to determine if osteopathic manipulation can alter the concentration of proteins and lipids in human tears.

Key Dates

First listed

Jun 8, 2026

Start date

Sep 1, 2026

Status verified

Aug 2026

Primary completion

Oct 2, 2026

Completion

Oct 31, 2026

Study Design

Enrollment

30 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Osteopathic Manipulative Treatment
  Sequential Osteopathic Manipulative Treatment of suboccipital 4-step release, occipital mastoid suture release, and sphenopalatine ganglion release.
• Sham Comparator: Sham

Primary Outcome Measure

Total tear protein concentration [ Time Frame: Baseline, 1 hour, and 1 week ]

Locations (1)

Find similar trials in Erie, PA

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