Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations

Part of paid clinical trials in Erie, Pennsylvania.

Sponsor
Lake Erie College of Osteopathic Medicine
Study ID
NCT07786467
Status
Recruiting
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Conditions

  • No Disease or Condition is Being Directly Studied
  • The Focus of the Study in Healthy Volunteers

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Osteopathic Manipulation — OTHER
    In this intervention, participants will receive 5 minutes of thoracic inlet myofascial release 2 days prior to influenza vaccination, the day of influenza vaccination and 4 days post-influenza vaccination.
  • Osteopathic manipulation — OTHER
    In this intervention, participants will receive osteopathic manipulation 2 days prior to influenza vaccination, the day of influenza vaccination, and 4 days post-influenza vaccination. The OMT will include thoracic inlet myofascial release, pectoral traction, rib raising, doming of the diaphragm, pelvic diaphragm release, popliteal fossa release, plantar myofascial release, passive Miller thoracic pump, liver pump, and spleen pump.
  • Sham — OTHER
    In this intervention, participants will receive no osteopathic treatments

Study Details

The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with advanced age and/or adiposity.

Key Dates

First listed
Aug 26, 2026
Start date
Sep 30, 2026
Status verified
Aug 2026
Primary completion
Oct 31, 2027
Completion
Oct 31, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Thoracic pump only
    Only thoracic inlet myofascial release
  • Sham Comparator: No intervention
    No intervention pre- or post-influenza vaccination.
  • Experimental: Complete lymphatic pumping
    Multiple sites of OMT to occur post-influenza vaccination.

Primary Outcome Measure

Hemagglutinin inhibition assay [ Time Frame: baseline and 4 weeks post vaccination ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Plaza 38 Medical OfficesEriePennsylvania16509
Jacob Cukierski, DO
[email protected]
814-860-8414
Stephany Esper, DO
[email protected]
814-860-8463
David Duriancik, Ph.D. (PRINCIPAL_INVESTIGATOR)
Jonathan Sharp, BS (SUB_INVESTIGATOR)
Jan Hendryx, DO (SUB_INVESTIGATOR)
Stephany Esper, DO (SUB_INVESTIGATOR)
Jacob Cukierski, DO (SUB_INVESTIGATOR)
Amanda Parker, BS (SUB_INVESTIGATOR)
Kayleigh Skolnick, BS (SUB_INVESTIGATOR)

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By research site
Plaza 38 Medical Offices· Erie, PA

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