Clinical Study on a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Chronic Kidney Disease Patients Based on MRI-FF

Sponsor
Capital Medical University
Study ID
NCT07645794
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • MRI-FF Scan — OTHER
    MRI fat-fraction (MRI-FF) scan of the lumbar spine and thigh, performed once for all participants to assess bone mineral density and muscle fat fraction.

Study Details

This is a single-center, observational cohort study aiming to validate the diagnostic value of MRI-FF in identifying osteoporosis and sarcopenia in patients with chronic kidney disease (CKD). A total of 868 participants, including 434 CKD patients and 434 non-CKD controls, will be enrolled at Beijing Jishuitan Hospital. All subjects will undergo MRI-FF scans of the lumbar spine and thigh to assess bone mineral density and muscle fat fraction. The primary objective is to evaluate the correlation between MRI-FF parameters and conventional diagnostic criteria for osteoporosis and sarcopenia, as well as to determine the optimal cut-off values for early detection. The study duration is from March 2026 to December 2028.

Key Dates

First listed
Jun 12, 2026
Start date
Jun 28, 2026
Status verified
Sep 2026
Primary completion
Dec 1, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
868 participants (estimated)

Arms

  • Arm: Chronic Kidney Disease (CKD) Group
    Patients with chronic kidney disease (CKD) who undergo MRI-FF scans of the lumbar spine and thigh to evaluate bone mineral density and muscle fat fraction.

Primary Outcome Measure

Correlation between MRI-FF-derived bone mineral density and DXA measurements [ Time Frame: At the time of the MRI-FF scan (baseline, one-time assessment) ]

Find similar trials

Nationwide
Chronic kidney disease trialsNephrology trialsKidney disease trials

Related Studies