Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Study ID
NCT07652580
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
4 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The goal of this observational cohort study is to learn how toxin and occupational exposures, germline genetic variation, and immune dysregulation relate to B-cell non-Hodgkin lymphoma among active-duty service members and other Military Health System beneficiaries. The main questions are whether specific exposures and germline variants are associated with B-cell NHL subtype, immune dysfunction, and clinical outcomes. Participants will complete exposure and medical-history surveys, provide biospecimens for immune and genomic testing, and may be followed annually for up to 3 years.

Key Dates

Start date
May 1, 2025
Status verified
Jun 2026
Primary completion
May 1, 2028
Completion
May 1, 2028

Study Design

Enrollment
300 participants (estimated)

Arms

  • Arm: Cohort 1
    Active duty service members (ADSMs) and other Military Health System (MHS) beneficiaries who have a history of B-cell non-Hodgkin Lymphoma (NHL) and have achieved clinical remission.
  • Arm: Cohort 2
    ADSMs and other MHS beneficiaries ages 18 and older who are newly diagnosed with B-cell NHL and/or are not undergoing active treatment.
  • Arm: Cohort 3
    Other MHS beneficiaries ages 4-17 who are diagnosed with B-cell NHL and are treatment naive.

Primary Outcome Measure

Aim 1: Characterize occupational exposures and their impact on health outcomes and immune health of ADSMs and other MHS beneficiaries with B-cell NHL. [ Time Frame: 3 years ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Uniformed Services University of the Health SciencesBethesdaMaryland20814-
Walter Reed National Military Medical CenterBethesdaMaryland20814
Christin B Destefano
[email protected]
(301) 295-3190
Annika Hamann, RN, BSN, BS
[email protected]
(301) 295-4198
Jeremy Perkins, MD, FACP, COL, US Army (ret) (PRINCIPAL_INVESTIGATOR)
Naval Medical Center PortsmouthPortsmouthVirginia23708-

Find similar trials in Bethesda, MD

By research site
Uniformed Services University of the Health Sciences· Bethesda, MDWalter Reed National Military Medical Center· Bethesda, MDNaval Medical Center Portsmouth· Portsmouth, VA

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