Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

Part of paid clinical trials in Columbia, Missouri.

Sponsor
University of Missouri-Columbia
Study ID
NCT07653464
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Insulin Resistance
  • Obesity (BMI>30)

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • human insulin — DRUG
    Participants will be administered human insulin (160 IU) using an intra-nasal device.

Study Details

In the present study, we seek to determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.

Key Dates

Start date
Aug 31, 2026
Status verified
Jun 2026
Primary completion
Jun 30, 2031
Completion
Jun 30, 2032

Study Design

Enrollment
64 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Insulin (Doppler)
    Human insulin (160 IU) will be administered using an intra-nasal device
  • Experimental: Insulin (MRI)
    Human insulin (160 IU) will be administered using an intra-nasal device.

Primary Outcome Measure

Amount of muscle sympathetic nerve activity (MSNA) [ Time Frame: Change from baseline at minute 30 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MissouriColumbiaMissouri65211
Jacqueline Limberg
[email protected]
573-882-2544
Jacqueline Limberg (PRINCIPAL_INVESTIGATOR)

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By research site
University of Missouri· Columbia, MO

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