Amygdala-Prefrontal in Fear Extinction
for Fear Extinction
1 location in St Louis
Sponsor: Washington University School of Medicine
Sex: All·Age: 18+
Code: NCT07800455·Recruiting·Listed Sep 2, 2026
Paid Clinical Trials in Missouri
Missouri has 1,983 paid clinical trials enrolling now across cities including St Louis, Kansas City and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.
Research sites in Missouri include Washington University School of Medicine, running studies across oncology, cardiology, neurology, and more. The most actively recruiting conditions are Breast Cancer, Obesity, Prostate Cancer, Heart Failure — browse the full list or use the filters to match your diagnosis. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Missouri
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Volunteer - Dosimetry Study)
for Healthy Adult
1 location in St Louis
Sponsor: Washington University School of Medicine
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07800481·EARLY_Phase 1·Recruiting·Listed Sep 2, 2026
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
for Type 2 Diabetes
Sites in St Louis, Kansas City +107 more locations
Sponsor: Novo Nordisk A/S
Sex: All·Age: 45+
Code: NCT07797335·Phase 3·Recruiting·Listed Sep 1, 2026
A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)
for Heart Failure With Preserved Ejection Fraction
Sites in St Louis, Kansas City +23 more locations
Sponsor: Edgewise Therapeutics, Inc.
Sex: All·Age: 30 - 84
Code: NCT07795814·Phase 2·Recruiting·Listed Aug 31, 2026
A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus
for Obesity or Overweight
Sites in Kansas City, Jefferson City +30 more locations
Sponsor: AstraZeneca
Sex: All·Age: 18+
Code: NCT07784725·Phase 3·Recruiting·Listed Aug 25, 2026
Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography
for Sickle Cell Disease
1 location in St Louis
Sponsor: Washington University School of Medicine
Sex: All·Age: 6 - 70·Accepts healthy volunteers
Code: NCT07776444·Recruiting·Listed Aug 20, 2026
1,765 clinical trials
Get a weekly email when new trials open in St Louis, MO.
A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
for Migraine
Drug: Elismetrep
Sites in St Louis, Kansas City +111 more locations
Sponsor: Kallyope Inc.
Sex: All·Age: 18 - 75
Code: NCT07645924·Phase 3·Recruiting·Listed Jun 2026
A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.
for Pneumococcal Disease
Sites in Columbia +105 more locations
Sponsor: Pfizer
Sex: All·Age: 42 Days - 211 Days·Accepts healthy volunteers
Code: NCT07629440·Phase 3·Recruiting·Listed Jun 2026
A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration
for Neovascular Age-related Macular Degeneration
Drug: Aflibercept
Sites in St Louis +53 more locations
Sponsor: Amgen
Sex: All·Age: 50+
Code: NCT07614776·Phase 3·Recruiting·Listed May 2026
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
for Obesity
Drug: NNC0487-0111
Sites in St Louis, Kansas City +204 more locations
Sponsor: Novo Nordisk A/S
Sex: All·Age: 18+
Code: NCT07567001·Phase 3·Recruiting·Listed May 2026
A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
for Cognitive Dysfunction
Drug: Donanemab
Sites in Bolivar +41 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 55 - 85
Code: NCT07589595·Phase 2·Recruiting·Listed May 2026
A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
for Alzheimer Disease
Drug: Donanemab
Sites in Bolivar +51 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 55+
Code: NCT07602582·Phase 3·Recruiting·Listed May 2026
A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)
for Overweight
Sites in Springfield +54 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT07575932·Phase 2·Recruiting·Listed May 2026
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
for Overweight
Drug: Eloralintide
Sites in Springfield, City of Saint Peters +38 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 75
Code: NCT07589608·Phase 2·Recruiting·Listed May 2026
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
for Major Depressive Disorder
Sites in St Louis +29 more locations
Sponsor: Definium Therapeutics US, Inc.
Sex: All·Age: 18 - 74
Code: NCT07592689·Phase 3·Recruiting·Listed May 2026
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)
for Cardiovascular Disease and Lipoprotein(a)
Drug: Pelacarsen
Sites in St Louis, City of Saint Peters +99 more locations
Sponsor: Novartis Pharmaceuticals
Sex: All·Age: 18 - 100
Code: NCT07517263·Phase 3·Recruiting·Listed Apr 2026
Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.
for Bipolar I Disorder
Sites in St Louis +25 more locations
Sponsor: LB Pharmaceuticals Inc.
Sex: All·Age: 18 - 65
Code: NCT07494305·Phase 2·Recruiting·Listed Mar 2026
Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
for Urothelial Cancer
Drug: PF-08634404
Sites in St Louis, City of Saint Peters +131 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT07421700·Phase 1, Phase 2·Recruiting·Listed Feb 2026
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
for Lichen Planopilaris
Sites in Kansas City, Lee's Summit +45 more locations
Sponsor: Priovant Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT07532603·Phase 2, Phase 3·Recruiting·Listed Apr 2026
Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention
for HIV Infections
Sites in St Louis, Kansas City +32 more locations
Sponsor: Gilead Sciences
Sex: All·Age: 18+
Code: NCT07473778·Recruiting·Listed Mar 2026
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
for Ulcerative Colitis (UC)
Drug: LY4268989
Sites in St Louis +49 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 80
Code: NCT07415044·Phase 2·Recruiting·Listed Feb 2026
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
for Depressive Disorder, Major
Drug: Brenipatide
Sites in St Louis +31 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 75
Code: NCT07412756·Phase 3·Recruiting·Listed Feb 2026
Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease
for Primary Sjogren's Disease
Drug: Telitacicept
Sites in Kansas City +42 more locations
Sponsor: Vor Biopharma
Sex: All·Age: 18 - 75
Code: NCT07404865·Phase 3·Recruiting·Listed Feb 2026
A Study of Brenipatide in Adult Participants With Schizophrenia
for Schizophrenia
Drug: Brenipatide
Sites in St Louis +31 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 55
Code: NCT07410507·Phase 2·Recruiting·Listed Feb 2026
A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH)
for MASH - Metabolic Dysfunction-Associated Steatohepatitis
Sites in St Louis, Kansas City +29 more locations
Sponsor: Rivus Pharmaceuticals, Inc.
Sex: All·Age: 30+
Code: NCT07491458·Phase 2·Recruiting·Listed Mar 2026
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
for Hepatitis
Drug: Larsucosterol
Sites in Kansas City +84 more locations
Sponsor: Bausch Health Americas, Inc.
Sex: All·Age: 18+
Code: NCT07428538·Phase 3·Recruiting·Listed Feb 2026
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
for Overweight
Drug: Eloralintide
Sites in Chesterfield +58 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07392190·Phase 3·Recruiting·Listed Feb 2026
A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
for Pancreatic Cancer
Sites in St Louis, Springfield +47 more locations
Sponsor: Astellas Pharma Global Development, Inc.
Sex: All·Age: 18+
Code: NCT07409272·Phase 3·Recruiting·Listed Feb 2026
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)
for Post Traumatic Stress Disorder
Drug: TSND-201
Sites in Creve Coeur, Saint Charles +30 more locations
Sponsor: Transcend Therapeutics
Sex: All·Age: 18+
Code: NCT07456696·Phase 3·Recruiting·Listed Mar 2026
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
for Non-small Cell Lung Cancer (NSCLC)
Drug: Durvalumab
Sites in Columbia +36 more locations
Sponsor: Bristol-Myers Squibb
Sex: All·Age: 18+
Code: NCT07361497·Phase 3·Recruiting·Listed Jan 2026
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
for Moderate to Severe Chronic Obstructive Pulmonary Disease
Drug: PF-07275315
Sites in St Louis +60 more locations
Sponsor: Pfizer
Sex: All·Age: 35 - 80
Code: NCT07363694·Phase 2, Phase 3·Recruiting·Listed Jan 2026
A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT
for Adenovirus Infections
Sites in St Louis +31 more locations
Sponsor: SymBio Pharmaceuticals
Sex: All·Age: 2 Months+
Code: NCT07387367·Phase 3·Recruiting·Listed Feb 2026
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
for Obesity or Overweight
Drug: Enicepatide
Sites in Springfield +40 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 18+
Code: NCT07351045·Phase 3·Recruiting·Listed Jan 2026
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
for Chronic Idiopathic Constipation (CIC)
Drug: Tenapanor
Sites in St Louis, Kansas City +107 more locations
Sponsor: Ardelyx
Sex: All·Age: 18 - 80
Code: NCT07382167·Phase 3·Recruiting·Listed Feb 2026
A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
for Non-Small Cell Lung Cancer (NSCLC)
Drug: Pumitamig
Sites in Columbia +40 more locations
Sponsor: Bristol-Myers Squibb
Sex: All·Age: 18+
Code: NCT07361510·Phase 3·Recruiting·Listed Jan 2026
A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older
for Clostridoides Difficile Associated Disease
Sites in St Louis +139 more locations
Sponsor: Pfizer
Sex: All·Age: 65+·Accepts healthy volunteers
Code: NCT07282665·Phase 3·Recruiting·Listed Dec 2025
A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)
for Metabolic Dysfunction-associated Steatohepatitis
Sites in St Louis, Columbia +61 more locations
Sponsor: Eccogene
Sex: All·Age: 18 - 75
Code: NCT07288138·Phase 2·Recruiting·Listed Dec 2025
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
for Overweight
Drug: Eloralintide
Sites in Springfield, Chesterfield +58 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07282600·Phase 3·Recruiting·Listed Dec 2025
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
for Breast Neoplasms
Sites in St Louis +33 more locations
Sponsor: Eli Lilly and Company
Sex: Female·Age: 18+
Code: NCT07287098·Phase 2·Recruiting·Listed Dec 2025
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
for CRC (Colorectal Cancer)
Drug: Bevacizumab
Sites in St Louis, Kansas City +69 more locations
Sponsor: Incyte Corporation
Sex: All·Age: 18+
Code: NCT07284849·Phase 3·Recruiting·Listed Dec 2025
Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease
for Diabetic Kidney Disease (DKD)
Sites in Kansas City, City of Saint Peters +56 more locations
Sponsor: Regeneron Pharmaceuticals
Sex: All·Age: 18 - 80
Code: NCT07271186·Phase 2·Recruiting·Listed Dec 2025
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
for Squamous Cell Carcinoma of Head and Neck
Drug: Amivantamab
Sites in St Louis +46 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 18+
Code: NCT07276399·Phase 3·Recruiting·Listed Dec 2025
Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
for Pancreatic Cancer
Drug: daraxonrasib
Sites in Kansas City +34 more locations
Sponsor: Revolution Medicines, Inc.
Sex: All·Age: 18+
Code: NCT07252232·Phase 3·Recruiting·Listed Nov 2025
Study of DONQ52 in Active Celiac Disease
for Celiac Disease
Drug: DONQ52
Sites in St Louis, Columbia +56 more locations
Sponsor: Chugai Pharmaceutical
Sex: All·Age: 18 - 75
Code: NCT07239336·Phase 2·Recruiting·Listed Nov 2025
Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy
for Diabetic Peripheral Neuropathic Pain
Sites in Kansas City, Hazelwood +68 more locations
Sponsor: Vertex Pharmaceuticals Incorporated
Sex: All·Age: 18 - 80
Code: NCT07231419·Phase 3·Recruiting·Listed Nov 2025
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
for Non-small Cell Carcinoma
Sites in Columbia +222 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT07144280·Phase 3·Recruiting·Listed Aug 2025
Common conditions studied in Missouri
- Breast Cancer (47 active studies)
- Obesity (41 active studies)
- Prostate Cancer (33 active studies)
- Heart Failure (30 active studies)
- Colorectal Cancer (26 active studies)
- Advanced Solid Tumor (21 active studies)
Leading research sponsors in Missouri
- Washington University School of Medicine
- National Cancer Institute (NCI)
- University of Missouri-Columbia
- AstraZeneca
- Eli Lilly and Company
Frequently asked questions
How many paid clinical trials are currently recruiting in Missouri?
There are approximately 1,983 recruiting clinical trials in Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Missouri pay participants?
Most recruiting trials in Missouri compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Missouri?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Missouri?
The most common conditions under active study in Missouri include Breast Cancer (47), Obesity (41), Prostate Cancer (33), Heart Failure (30), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Missouri?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Missouri on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Missouri?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Browse more clinical trials
All cities in Missouri
St Louis, MO(1,416)Kansas City, MO(458)Columbia, MO(230)Springfield, MO(124)City of Saint Peters, MO(92)Cape Girardeau, MO(84)Creve Coeur, MO(75)Lee's Summit, MO(67)Farmington, MO(64)Sainte Genevieve, MO(63)Sullivan, MO(62)Saint Joseph, MO(56)Chesterfield, MO(51)Osage Beach, MO(46)Joplin, MO(41)Ballwin, MO(39)Rolla, MO(38)Bolivar, MO(34)Saint Charles, MO(29)Washington, MO(29)Branson, MO(27)Sunset Hills, MO(23)Jefferson City, MO(20)Liberty, MO(19)Bridgeton, MO(17)Hazelwood, MO(11)Hannibal, MO(9)North Kansas City, MO(9)O'Fallon, MO(9)Independence, MO(8)Town and Country, MO(6)Kirksville, MO(5)Fenton, MO(4)Florissant, MO(4)Weldon Spring, MO(3)Chillicothe, MO(2)Saint Loius, MO(2)Annapolis, MO(1)Belton, MO(1)Bethany, MO(1)Carrollton, MO(1)Carthage, MO(1)Clinton, MO(1)Des Peres, MO(1)Excelsior Springs, MO(1)Festus, MO(1)Frontenac, MO(1)Kansa City, MO(1)Lake Saint Louis, MO(1)Lebanon, MO(1)Louis, MO(1)Manchester, MO(1)Marshall, MO(1)Overland, MO(1)Overland Park, MO(1)Ozark, MO(1)Poplar Bluff, MO(1)Raymore, MO(1)Raytown, MO(1)Roseville, MO(1)Troy, MO(1)Vandalia, MO(1)Warrensburg, MO(1)West Plains, MO(1)Wildwood, MO(1)