Olfactory Transcranial Focused Ultrasound

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT07658365
Status
Recruiting
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Conditions

  • Healthy
  • Olfaction

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • transcranial focused ultrasound (tFUS) — DEVICE
    non-invasive brain stimulation using tFUS

Study Details

This study investigates the causal effects of low-intensity transcranial focused ultrasound (tFUS) on odor valence perception and odor-elicited avoidance behaviors in healthy adults. Participants undergo sham and active tFUS targeting the amygdala (AMYG) and ventral striatal olfactory tubercle (VSOT) in a within-subject, randomized, sham-controlled crossover design. Outcomes include subjective odor ratings and objective neurophysiological and behavioral indices of odor valence processing. This research is exploratory and mechanistic in nature and is not intended to evaluate clinical safety or therapeutic efficacy.

Key Dates

First listed
Jun 22, 2026
Start date
Oct 1, 2026
Status verified
Oct 2026
Primary completion
Apr 30, 2028
Completion
Apr 30, 2028

Study Design

Enrollment
28 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Active tFUS targeting the Amygdala (AMYG)
    Active tFUS of the bilateral Amygdala randomized at one of the three stimulation visits
  • Experimental: Active tFUS targeting the Ventral Striatal Olfactory Tubercle (VSOT)
    Active tFUS of the bilateral VSOT randomized at one of the three stimulation visits
  • Sham Comparator: Sham tFUS
    Sham tFUS randomized at one of three stimulation visits

Primary Outcome Measure

Odor Valence Rating [ Time Frame: from the baseline visit until the third follow-up visit (about 1 month) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29425
Nicole Cash
[email protected]
8437903449
Aly Grella
[email protected]
8437903449

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Medical University of South Carolina· Charleston, SC

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