Olfactory Dysfunction in Aging Adults

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT07660887
Status
Not Yet Recruiting

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Conditions

  • Olfactory Dysfunction

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Clinical and Biomarker Assessments — OTHER
    Participants undergo olfactory testing (Sniffin' Sticks), cognitive assessment, nasal endoscopy, olfactory mucus collection, MRI imaging (subset), and patient-reported outcome measures to evaluate olfactory function, biomarkers, and health outcomes over time.

Study Details

This prospective longitudinal cohort study will enroll adults aged 50 years and older to characterize olfactory dysfunction in aging. Participants will undergo comprehensive olfactory testing, cognitive assessment, biomarker collection, and imaging to identify clinically relevant phenotypes based on anatomic site of dysfunction. The study will also evaluate the impact of olfactory dysfunction on quality of life and identify baseline factors associated with changes in olfactory function over time.

Key Dates

Start date
Apr 1, 2027
Status verified
Jun 2026
Primary completion
Apr 30, 2032
Completion
Apr 30, 2032

Study Design

Enrollment
500 participants (estimated)

Arms

  • Arm: Older Adults With and Without Olfactory Dysfunction
    Adults aged 50 years and older enrolled in a prospective cohort study assessing olfactory function, cognition, biomarkers, and quality of life, with annual follow-up. Participants will be classified post hoc into olfactory phenotypes based on testing results.

Primary Outcome Measure

Olfactory Function [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
MUSCCharlestonSouth Carolina29425
Rodney Schlosser, MD
[email protected]
8437927165

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