Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver)

Part of paid clinical trials in Phoenix, Arizona.

Sponsor: Johns Hopkins University
Study ID: NCT07665372
Status: Recruiting

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Conditions

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Interventions

HIV D+/R+ — OTHER
Receipt of liver transplant from a deceased donor with HIV
HIV D-/R+ — OTHER
Receipt of liver transplant from a deceased donor without HIV

Study Details

This research is being done to better understand opportunistic infections and cancer in transplant recipients with HIV who receive livers from a donor with HIV compared to livers from donors without HIV.

Key Dates

First listed: Jun 24, 2026
Start date: Nov 30, 2026
Status verified: Sep 2026
Primary completion: Aug 31, 2030
Completion: Aug 31, 2031

Study Design

Enrollment: 80 participants (estimated)
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Arms

Experimental: HIV D+/R+
People living with HIV who receive livers from deceased donors with HIV
Experimental: HIV D-/R+
People living with HIV who receive livers from deceased donors without HIV

Primary Outcome Measure

Incidence of a composite event of opportunistic infection or cancer in HIV D+/R+ compared to HIV D-/R+ LT [ Time Frame: From transplant through end of follow up (at least 6 months year, up to 4 years post-transplant) ]

Central Contacts

Christine Durand, MD
410-614-6702
[email protected]

Locations (19)

Facility	City	State	ZIP	Site coordinators
Mayo Clinic, Arizona	Phoenix	Arizona	85054	Andrew Singer, MD, PhD [email protected] Andrew Singer, MD, PhD (PRINCIPAL_INVESTIGATOR)
Cedars-Sinai Medical Center	Los Angeles	California	90048	Nicholas Nissen, MD [email protected] Nicholas Nissen, MD (PRINCIPAL_INVESTIGATOR)
University of California, San Francisco	San Francisco	California	94143	Jennifer Price, MD [email protected] Jennifer Price, MD (PRINCIPAL_INVESTIGATOR)
University of Colorado Anschutz	Aurora	Colorado	80045	Chia-Yu Chiu, MD [email protected] Chia-Yu Chiu, MD (PRINCIPAL_INVESTIGATOR)
Mayo Clinic, Florida	Jacksonville	Florida	32224	Shennen Mao, MD [email protected] Shennen Mao, MD (PRINCIPAL_INVESTIGATOR)
University of Miami, Miami Transplant Institute	Miami	Florida	33136	Jacques Simkins-Cohen, MD [email protected] Jacques Simkins-Cohen, MD (PRINCIPAL_INVESTIGATOR)
Emory University	Atlanta	Georgia	30322	William Kitchens, MD, PhD [email protected] William Kitchens, MD, PhD (PRINCIPAL_INVESTIGATOR)
Northwestern University	Chicago	Illinois	60611	Valentina Stosor, MD [email protected] Valentina Stosor, MD (PRINCIPAL_INVESTIGATOR)
Ochsner Clinic Foundation	Jefferson	Louisiana	70121	Jonathan Hand, MD [email protected] Jonathan Hand, MD (PRINCIPAL_INVESTIGATOR)
Johns Hopkins University	Baltimore	Maryland	21205	Christine Durand, MD [email protected] Christine Durand, MD (PRINCIPAL_INVESTIGATOR)
Massachusetts General Hospital	Boston	Massachusetts	02114	Nahel Elias, MD [email protected] Nahel Elias, MD (PRINCIPAL_INVESTIGATOR)
Icahn School of Medicine at Mount Sinai	New York	New York	10029	Sander Florman, MD Sander Florman, MD (PRINCIPAL_INVESTIGATOR)
New York University School of Medicine	New York	New York	10016	Sapna Mehta, MD [email protected] Sapna Mehta, MD (PRINCIPAL_INVESTIGATOR)
Weill Cornell Medical College	New York	New York	10065	Catherine B Small, MD [email protected] Catherine B Small, MD (PRINCIPAL_INVESTIGATOR)
University of Cincinnati	Cincinnati	Ohio	45229	Senu Apewokin, MD [email protected] Senu Apewokin, MD (PRINCIPAL_INVESTIGATOR)
Ohio State University Medical Center	Columbus	Ohio	43210	Nicholas Marschalk, DO [email protected] Nicholas Marschalk, DO (PRINCIPAL_INVESTIGATOR)
University of Pittsburgh Medical Center	Pittsburgh	Pennsylvania	15224	Ghady Haidar, MD [email protected] Ghady Haidar, MD (PRINCIPAL_INVESTIGATOR)
University of Texas Southwestern Medical Center	Dallas	Texas	75390	David Wojciechowski, DO [email protected] David Wojciechowski, DO (PRINCIPAL_INVESTIGATOR)
Houston Methodist Research Institute	Houston	Texas	77030	Masayuki Nigo, MD MSc [email protected] Masayuki Nigo, MD, MSc (PRINCIPAL_INVESTIGATOR)

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Mayo Clinic, Arizona· Phoenix, AZ Cedars-Sinai Medical Center· Los Angeles, CA University of California, San Francisco· San Francisco, CA University of Colorado Anschutz· Aurora, CO Mayo Clinic, Florida· Jacksonville, FL University of Miami, Miami Transplant Institute· Miami, FL

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