NON-INVASIVE BRAIN STIMULATION FOR MEMORY LOSS IN EARLY ALZHEIMER'S DISEASE

Part of paid clinical trials in Houston, Texas.

Sponsor
Chi-Ying (Roy) Lin
Study ID
NCT07667478
Status
Recruiting
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Conditions

  • Alzheimer s Disease
  • Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
  • Mild Dementia

Eligibility Criteria

Sex
ALL
Age
55 Years - 90 Years
Healthy Volunteers
Not accepted

Interventions

  • repetitive transcranial magnetic stimulation (rTMS) — DEVICE
    This is an early phase study investigating the effects of rTMS on individuals with early AD.
  • sham repetitive transcranial magnetic stimulation rTMS — OTHER
    sham rTMS

Study Details

The goal of this clinical trial is to learn if repetitive transcranial magnetic stimulation (rTMS), a non-invasive form of brain stimulation, can improve short-term memory in people with early Alzheimer's disease (AD). The study will also evaluate the safety of this approach. The main questions it aims to answer are: * Does rTMS applied to the cerebellum improve short-term memory in people with early AD? * How does this stimulation affect brain activity and connectivity measured by MRI? Researchers will compare active rTMS to sham rTMS (a look-alike procedure that does not deliver brain stimulation) to see if rTMS works to improve memory. Participants will: * Complete a screening visit with medical and memory assessments * Be randomly assigned to receive either active rTMS or sham rTMS (neither participants nor researchers will know the assignment during treatment) * Receive 20 rTMS sessions over 4 weeks (about 20 to 30 minutes per session) * Undergo two MRI scans, one before and one after treatment * Complete memory and thinking tests and questionnaires at baseline, immediately after treatment, and at 3- and 6-month follow-up visits Participation in the study will last about 6 months. The rTMS is generally well tolerated. The most common side effects include mild headache and scalp discomfort during treatment, which are usually short-lasting. MRI is non-invasive and safe for most people. Study procedures will be reviewed to ensure participant safety. Participants may or may not benefit directly from this study. People who receive active rTMS may experience improvement in memory. This research may help improve understanding of memory function in AD and support development of new treatments.

Key Dates

Start date
Apr 15, 2026
Status verified
Jun 2026
Primary completion
Apr 14, 2031
Completion
Apr 14, 2031

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: repetitive transcranial magnetic stimulation (rTMS)
    cerebellar rTMS group
  • Sham Comparator: sham
    Sham controlled group

Primary Outcome Measure

MMSE [ Time Frame: immediate, 3-months post rTMS, 6-months post rTMS ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Baylor College of MedicineHoustonTexas77030
Rory Mahabir, MBA, CCRP
[email protected]
713-798-5989
Chi-Ying Roy Lin, MD, MPH (PRINCIPAL_INVESTIGATOR)

Find similar trials in Houston, TX

By research site
Baylor College of Medicine· Houston, TX

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