Aerobic Exercise as a Countermeasure for Night Shift Associated Circadian Misalignment

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT07668622
Status
Not Yet Recruiting

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Conditions

  • Circadian Misalignment
  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Not accepted

Interventions

  • Exercise — BEHAVIORAL
    Participants will engage in a 5-day stay that includes simulated daytime work, with nighttime sleep, followed by 3 days of simulated night shift work, with daytime sleep. On days 1, 3, and 4, participants will be provided food to eat (Day 1 +/- 1 hour:\~18:00 and \~23:00, Day 3 +/- 1 hour: \~08:30, \~13:00, \~18:00, \~23:00, and \~04:00. Day 4 +/-1 hour: \~18:00, \~23:00, \~04:00, and \~07:00). On days 2 and 5, participants will be provided with a diet to maintain your current weight (30% breakfast, 30% lunch, 30% dinner, 10% snack). On Day 2, participants will be provided a diet to be consumed at the following times: breakfast 08:30, lunch 13:00, dinner 18:00, snack 23:00. On Day 5, participants will follow a night shift schedule and meal timing that will follow the following schedule: breakfast 18:00, lunch 23:00, dinner 04:00, snack 07:00. Participants will engage in a 45-minute bout of moderate intensity aerobic exercise at 2.5 h after waking on days 3, 4, and 5.

Study Details

This study plans to learn more about whether exercise can help protect the body from health problems that happen when a person's sleep and daily schedule are out of sync with their natural body clock (circadian rhythm).

Key Dates

Start date
Jul 1, 2026
Status verified
Jun 2026
Primary completion
Dec 1, 2027
Completion
Jul 1, 2028

Study Design

Enrollment
16 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • No Intervention: Control
    Participants in this arm will engage in simulated daytime work, with nighttime sleep, followed by 3 days of simulated night shift work, with day time sleep.
  • Experimental: Exercise
    Participants in this arm will engage in simulated daytime work, with nighttime sleep, followed by 3 days of simulated night shift work, with day time sleep. In addition, participants will engage in a 45-minute bout of moderate intensity exercise at 2.5 hours after waking on days 3, 4, and 5.

Primary Outcome Measure

24-hour ambulatory BP [ Time Frame: Days 2 and 5 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Colorado Anschutz Medical CampusAuroraColorado80045
Justin Lorentzen, BHS
[email protected]
303-724-3685
Seth Creasy, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Colorado Anschutz Medical Campus· Aurora, CO

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