Health Ahead Comparative Effectiveness Study

Part of paid clinical trials in Boulder, Colorado.

Sponsor
William Brandenburg, MD
Study ID
NCT07669168
Status
Recruiting
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Conditions

  • Activities of Daily Living
  • Aging
  • Cardiovascular Diseases
  • Cognitive Dysfunction
  • Frailty
  • Health Behavior
  • Health Equity
  • Health Related Quality of Life
  • Health Services Accessibility
  • Medically Underserved Area
  • Metabolic Syndrome
  • Patient Participation
  • Preventive Health Services
  • Rural Health
  • Telemedicine

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • AI-Assisted Screening Interpretation (AI Reads) — BEHAVIORAL
    An AI-generated read of the acquired screening battery is produced and presented to the physician of record as a clinical aid. All models used are third-party models, executed unmodified on Longevity Metrics clinical infrastructure. The physician reviews each read, records a structured judgment before sign-off, and then produces and signs the released interpretation, which may adopt, modify, or reject any read.
  • Human-Only Screening Interpretation — BEHAVIORAL
    All acquired screening data, images, tracings, and laboratory results are interpreted by the physician of record and qualified clinical staff under physician supervision, by standard practice and without AI decision support. This is the current standard of care and the active comparator.

Study Details

The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening system deployable in any environment, including the most isolated and resource-limited communities. Each change is isolated as a single variable against current practice, and every comparison is evaluated with a common set of engagement, behavior-change, experience, cost, and longitudinal outcome measures, so results accumulate on a consistent yardstick across the life of the platform. The first comparison evaluates AI-assisted versus human-only interpretation ("reads") of screening data. Subsequent pre-planned comparisons, added by protocol amendment, evaluate static versus interactive personalized report delivery; mobile community versus fixed laboratory screening; and a hybrid medical-droid-plus-human delivery model versus human-only screening.

Key Dates

First listed
Jun 25, 2026
Start date
Jun 9, 2026
Status verified
Sep 2026
Primary completion
Dec 31, 2099
Completion
Dec 31, 2099

Study Design

Enrollment
1,000,000 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH

Arms

  • Active Comparator: Human-Only Screening Interpretation
    Participants receive comprehensive preventive health screening under the standard of care for the comparison in progress. In the active comparison, all screening data, images, tracings, and laboratory results are interpreted by the physician of record and qualified clinical staff under physician supervision, without AI decision support.
  • Experimental: AI-Assisted Screening Interpretation (AI Reads)
    Participants receive identical screening with one element modified: the single variable under test in the comparison in progress. In the active comparison, models produce AI-generated reads of the acquired data, presented to the physician of record as a clinical aid. The physician reviews each read, records a structured judgment before sign-off, and produces and signs the released interpretation. The comparison runs in two screening-complexity strata, with a single general model in the simple stratum and a general model plus at least three domain-specific models in the comprehensive stratum.

Primary Outcome Measure

Health Awareness and Action (Non-Inferiority) [ Time Frame: Baseline (intake, completed at home before the screening visit); 1-2 weeks after screening, at report delivery; 6-12-month follow-up; then periodically from enrollment until death, up to 100 years. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Longevity MetricsBoulderColorado80301
William Brandenburg, MD
[email protected]
3035010016

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