Health Ahead Comparative Effectiveness Study

Part of paid clinical trials in Boulder, Colorado.

Sponsor
William Brandenburg, MD
Study ID
NCT07669168
Status
Recruiting
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Conditions

  • Activities of Daily Living
  • Aging
  • Cardiovascular Diseases
  • Cognitive Dysfunction
  • Frailty
  • Health Behavior
  • Health Equity
  • Health Related Quality of Life
  • Health Services Accessibility
  • Medically Underserved Area
  • Metabolic Syndrome
  • Patient Participation
  • Preventive Health Services
  • Rural Health
  • Telemedecine

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Interactive Personalized Health Report — BEHAVIORAL
    Static versus interactive health report
  • Mobile Community-Based Health Screenings — BEHAVIORAL
    Mobile versus Fixed Laboratory Health Screenings
  • Hybrid Medical Droid and Human Delivered Health Screenings — BEHAVIORAL
    Hybrid Medical Droid and Human Delivered versus Human-Only Delivered Health Screenings

Study Details

The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening - each isolated as a single variable against current practice - on the path toward a fully automated screening system deployable in any environment, including the most isolated and resource-limited communities. Each comparison is evaluated with a common set of engagement, behavior-change, experience, cost, and longitudinal outcome measures, allowing results to accumulate on a consistent yardstick across the life of the platform. The first comparison evaluates static versus interactive personalized health report delivery. Subsequent pre-planned comparisons, added by protocol amendment, evaluate mobile community versus fixed laboratory screening; and a hybrid medical-droid plus human-delivery model versus human-only screening. All participants are simultaneously enrolled in the 100-Year Human Aging Study and the Human Observatory Study, contributing individual longitudinal and population-level causal inference data through those protocols.

Key Dates

Start date
Jun 9, 2026
Status verified
Jun 2026
Primary completion
Dec 31, 2099
Completion
Dec 31, 2099

Study Design

Enrollment
1,000,000 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
HEALTH_SERVICES_RESEARCH

Arms

  • Active Comparator: Static Personalized Health Report
    Participants complete comprehensive multi-system health screening and receive a standard static personalized health report.
  • Experimental: Interactive Personalized Health Report
    Participants complete identical comprehensive multi-system health screening and receive an interactive personalized report allowing real-time adjustment of behaviors and diagnostic inputs to visualize projected changes in composite scores, estimated biological age, and aging trajectory.
  • Active Comparator: Fixed-Lab Health Screenings
    Health screenings performed at fixed-lab site.
  • Experimental: Mobile Lab Health Screenings
    Health screenings performed in remote locations using a mobile lab
  • Active Comparator: Human Delivered Health Screenings
    Health screenings delivered by human operators only
  • Experimental: Hybrid Medical Droid and Human Delivered Health Screenings
    Health screenings delivered by a hybrid model using medical droid and human operators

Primary Outcome Measure

Health Activation and Engagement (Non-Inferiority) [ Time Frame: Baseline, 6-12-month follow-up, then periodically from enrollment until death, up to 100 years. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Longevity MetricsBoulderColorado80301
William Brandenburg, MD
[email protected]
3035010016

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