A Study of ELI-002 7P, With or Without Tislelizumab, in People With Pancreatic Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07671339
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • ELI-002 7P — DRUG
    a subcutaneous (SC) injection under the skin
  • Tislelizumab — DRUG
    s an intravenous (IV) infusion
  • mFOLFIRINOX — DRUG
    neoadjuvant mFOLFIRINOX (5-Fluorouracil,oxaliplatin, leucovorin, irinotecan)

Study Details

The researchers are doing this study to find out whether ELI-002 7P in combination with mFOLFIRINOX, with or without tislelizumab, is a safe treatment approach in people who have pancreatic ductal adenocarcinoma (PDAC) with a KRAS mutation. In addition, the researchers are doing this study to find out whether the study treatment is effective against PDAC.

Key Dates

Start date
Jun 22, 2026
Status verified
Jun 2026
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: ELI-002 7P concurrent with mFOLFIRINOX
    Participants receives ELI-002 7P during adjuvant chemotherapy.
  • Experimental: Tislelizumab in addition to ELI-002 7P and mFOLFIRINOX.
    Participants will receive Ttislelizumab IV every four weeks concurrent with ELI-002 7P.

Primary Outcome Measure

the proportion of patients with a Grade 3 or higher drug-related adverse event (AE) [ Time Frame: 2 years ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Kevin Soares, MD
212-639-3195
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)MiddletownNew Jersey07748
Kevin Soares, MD
212-639-3195
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Kevin Soares, MD
212-639-3195
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)CommackNew York11725
Kevin Soares, MD
212-639-3195
Memorial Sloan Kettering Westchester (Limited Protocol Activities)HarrisonNew York10604
Kevin Soares, MD
212-639-3195
Memorial Sloan Kettering Cancer Center (All Protocol Activites)New YorkNew York10065
Kevin Soares, MD
212-639-3195
Memorial Sloan Kettering Nassau (Limited Protocol Activites)Rockville CentreNew York11553
Kevin Soares, MD
212-639-3195

Find similar trials in Basking Ridge, NJ

By condition
Pancreatic cancer
By specialty
OncologyGI oncology
By research site
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activites)· New York, NY

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