Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

Part of paid clinical trials in Columbia, Missouri.

Sponsor
University of Missouri-Columbia
Study ID
NCT07674680
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Placebo — DRUG
    Participants will receive a placebo in pill form.
  • Gemtesa — DRUG
    Participants will receive oral gemtesa (75 mg).

Study Details

To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.

Key Dates

First listed
Jun 29, 2026
Start date
Jul 31, 2026
Status verified
Sep 2026
Primary completion
May 31, 2028
Completion
May 31, 2029

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Cold pressor test
    Participants will be exposed to the cold pressor test (ice water on the foot).
  • Experimental: Flow Mediated Dilation
    Participants will be exposed to the high-resolution ultrasound following inflation of a cuff around the forearm.

Primary Outcome Measure

Blood flow [ Time Frame: Change from baseline to minute 2. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MissouriColumbiaMissouri65211
Jacqueline Limberg Associate Professor
[email protected]
1-573-882-2544

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