Atropine Eye Drops for Watery Eyes (Excessive Tearing)

Conditions

• Epiphora

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Atropine ophthalmic solution — DRUG
  The interventions are two low doses of atropine ophthalmic solution

Study Details

The goal of this clinical trial is to learn if low-dose atropine eye drops work to reduce excessive watery eyes (epiphora) in adults. It will also learn about the safety of the eye drops. The main questions it aims to answer are: Do the eye drops reduce how often participants have watery eyes? What medical problems do participants have when taking the eye drops? Researchers will compare two strengths of the eye drops (0.005% and 0.01%) to see whether one works better than the other and whether the lower strength works as well as the higher one. Participants will: * Use the assigned eye drops in the affected eye(s) for one week * Visit the clinic twice for checkups and eye tests * Receive a follow-up phone call about two weeks after starting, to check on any symptoms

Key Dates

First listed

Jun 30, 2026

Start date

Jun 16, 2026

Status verified

Sep 2026

Primary completion

Jul 6, 2026

Completion

Jul 15, 2026

Study Design

Enrollment

18 participants (actual)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Atropine ophthalmic solution 0.005%
  Atropine ophthalmic solution 0.005%
• Experimental: Atropine ophthalmic solution 0.01%
  Atropine ophthalmic solution 0.01%

Primary Outcome Measure

Munk Score Change [ Time Frame: Time Frame: From enrollment to the end of treatment at 1 week ]

Locations (2)

Find similar trials in Houston, TX

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