Mild Cognitive Impairment and Neuromodulation

Part of paid clinical trials in Roanoke, Virginia.

Sponsor
Virginia Polytechnic Institute and State University
Study ID
NCT07691918
Status
Enrolling By Invitation

Conditions

  • Mild Cognitive Impairment (MCI)

Eligibility Criteria

Sex
ALL
Age
55 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Low intensity focused ultrasound — DEVICE
    low-intensity focused ultrasound applied with a two element transducer from sonic concepts.
  • Sham (No Treatment) — DEVICE
    Blocked LIFU

Study Details

This is a parallel, sham-controlled design of low-intensity focused ultrasound in patients with mild cognitive impairment (MCI). The study will evaluate safety, tolerability, and effects on cognitive function.

Key Dates

First listed
Jul 9, 2026
Start date
Jul 31, 2026
Status verified
Jul 2026
Primary completion
Jul 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Real LIFU
    Active Low Intensity Focused Ultrasound application
  • Sham Comparator: Sham LIFU
    Blocked LIFU energy to the same brain region as the active group.

Primary Outcome Measure

Safety of LIFU in MCI patients - Report of Symptoms Assessment [ Time Frame: Throughout study participation - about 6 months in total. ]

Locations (1)

FacilityCityStateZIPSite coordinators
Fralin Biomedical Research Institute at VTCRoanokeVirginia24016-

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Fralin Biomedical Research Institute at VTC· Roanoke, VA

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