Paid Clinical Trials in Roanoke, VA
As of September 2026, 151 paid clinical trials are recruiting in Roanoke, Virginia. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Roanoke offers studies at sites including Carilion Clinic for conditions such as Prostate Cancer, Cardiovascular Diseases, Heart Failure, Ulcerative Colitis. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Roanoke
Trials by drug in Roanoke
Filter results
Newly added in Roanoke
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label Devices
134 clinical trials
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus
A Study of Brenipatide in Participants With Opioid Use Disorder
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
Top Research Study Locations in Roanoke
Researchers run research studies in Roanoke, VA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Carilion Clinic | Focal Epilepsy, Heart Failure, Cardiovascular Diseases | 28 |
| Carilion Children's | B Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Malignant Solid Neoplasm | 15 |
| Carilion Roanoke Memorial Hospital | Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Advanced Malignant Solid Neoplasm | 13 |
| Blue Ridge Cancer Care | Cancer of the Prostate, Follicular Lymphoma, Gastric Cancer | 11 |
| Fralin Biomedical Research Institute at VTC | Chronic Pain, Anxiety Disorder, Autonomic Dysfunction | 10 |
| Oncology and Hematology Associates of Southwest Virginia (BRCC) | Biliary Tract Cancer, Colorectal Cancer, Pancreatic Ductal Adenocarcinoma | 4 |
| Fralin Biomedical Research Institute | Development of LIFU for Clinical Purposes, Pain, Post Traumatic Stress Disorder | 3 |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Advanced Renal Cell Carcinoma, Advanced or Metastatic Renal Cell Carcinoma, Carcinoma, Renal Cell | 3 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Carilion Children's Tanglewood Center | Crohn's Disease, Crohn's Disease (CD), Ulcerative Colitis | 2 |
| Fairlawn Surgery Center | Dialysis; Complications, End Stage Renal Disease, Vascular Access Complication | 2 |
| Fralin Biomedical Research Institute at Virginia Tech Carilion | Cigarette Smoking, E-cigarette Use, Neurobehavioral Components of Reward and Loss Valuation | 2 |
| Gastroenterology Consultants of Southwest Virginia | Metabolic Dysfunction-Associated Steatotic Liver Disease, Obesity or Overweight, Ulcerative Colitis | 2 |
| Gastroenterology Consultants of Southwest Virginia. | Crohn's Disease, Moderately to Severely Active Crohn Disease, Ulcerative Colitis | 2 |
| Onco Hemato Asso of SW Virginia | Prostate Cancer | 2 |
| Oncology & Hematology Associates of Southwest Virginia, Inc. | Extensive-Stage Small Cell Lung Cancer, Melanoma | 2 |
| Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care | Advanced/Metastatic Urothelial Cancer, Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Carcinoma | 2 |
| Professional Education and Research Institute | Diabetic Foot Ulcers (DFUs), Venous Leg Ulcers | 2 |
| Carilion Roanoke Memorial Hospital | Epithelial Ovarian Cancer, Fallopian Tube Cancer, Neoadjuvant | 2 |
| Vistar Eye Center | Diabetic Macular Edema, Age-Related Macular Degeneration, Choroidal Neovascularization | 2 |
| 89bio Clinical Study Site | Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis | 1 |
| Anthos Investigative | Atrial Fibrillation (AF) | 1 |
| Artiva Investigational | IIM, Idiopathic Inflammatory Myopathies (IIMs), Myositis | 1 |
| Blue Ridge Cancer Care - 300202915 | Metastatic Colorectal Cancer | 1 |
| Blue Ridge Cancer Care - Roanoke | Multiple Myeloma | 1 |
Active & Upcoming Studies in Roanoke (2026)
Recruiting trials in Roanoke grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (55 active studies)
- A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03) · Phase 3 · EMD Serono Research & Development Institute, Inc.
- Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer · Phase 1, Phase 2 · Pfizer
Neurology & pain (10 active studies)
- LIFU for Chronic Pain and Generalized Anxiety Disorder · Virginia Polytechnic Institute and State University
- A Study to Evaluate the Safety and Efficacy of JZP926 Capsule for the Treatment of Juvenile Myoclonic Epilepsy · Phase 2, Phase 3 · Jazz Pharmaceuticals
Cardiovascular (9 active studies)
- A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation. · P+F Products + Features USA Inc.
- Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity · Phase 3 · Amgen
Mental health & behavior (7 active studies)
- LIFU for Chronic Pain and Generalized Anxiety Disorder · Virginia Polytechnic Institute and State University
- Generalized and Domain-Specific Episodic Thinking for Smoking Cessation · Virginia Polytechnic Institute and State University
Diabetes & metabolic (7 active studies)
- A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide · Phase 3 · Novo Nordisk A/S
- Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study · Phase 3 · Eli Lilly and Company
Eye & vision (2 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Kamuvudine-9 (K9) in Diabetic Macular Edema · Phase 1, Phase 2 · Dr. Bryan Strelow
Pediatric (1 active study)
- The FBRI VTC Neuromotor Research Clinic · Virginia Polytechnic Institute and State University
Common conditions studied in Roanoke
- Prostate Cancer (5 active studies)
- Cardiovascular Diseases (4 active studies)
- Heart Failure (4 active studies)
- Ulcerative Colitis (4 active studies)
- B Acute Lymphoblastic Leukemia (3 active studies)
- Breast Neoplasms (3 active studies)
Leading research sponsors in Roanoke
- Virginia Polytechnic Institute and State University
- Children's Oncology Group
- Merck Sharp & Dohme LLC
- Carilion Clinic
- Eli Lilly and Company
Frequently asked questions
How many paid clinical trials are currently recruiting in Roanoke?
There are approximately 151 recruiting clinical trials in Roanoke, Virginia listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Roanoke pay participants?
Most recruiting trials in Roanoke compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Roanoke?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Roanoke?
The most common conditions under active study in Roanoke include Prostate Cancer (5), Cardiovascular Diseases (4), Heart Failure (4), Ulcerative Colitis (4), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Roanoke?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Roanoke on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Roanoke?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Roanoke?
Recruiting research sites in Roanoke include Carilion Clinic, Carilion Children's, Carilion Roanoke Memorial Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Roanoke right now?
The largest active categories in Roanoke are Cancer & tumors (55), Neurology & pain (10), Cardiovascular (9). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.