Oral Nicotine Product Messaging to Communicate Risk of Use for Young Adults

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Ohio State University Comprehensive Cancer Center
Study ID
NCT07702435
Status
Completed

Conditions

  • Tobacco-Related Carcinoma

Eligibility Criteria

Sex
ALL
Age
18 Years - 30 Years
Healthy Volunteers
Accepted

Interventions

  • Behavioral Intervention — BEHAVIORAL
    Receive messaging regarding addiction beliefs
  • Behavioral Intervention — BEHAVIORAL
    Receive messaging regarding relative risk beliefs about the risks of ONPs relative to cigarettes and e-cigarettes
  • Behavioral Intervention — BEHAVIORAL
    Receive messaging regarding self and response efficacy beliefs about ability to use ONPs instead of cigarettes/e-cigarettes and the potential benefits of doing so
  • Behavioral Intervention — BEHAVIORAL
    Receive messaging regarding switching beliefs about the potential benefits of switching to ONPs
  • Survey Administration — OTHER
    Ancillary studies

Study Details

This clinical trial tests the effect of different types of oral nicotine pouch (ONP) messaging to communicate risk of using these products for young adults. Tobacco use remains the leading preventable cause of death due to cancer and other outcomes in the U.S. Tobacco products vary in the health risks they pose to users. Combustible tobacco products such as cigarettes pose higher risks than noncombustible nicotine and tobacco products such as ONPs. Despite the lower harm potential of ONPs for those who use tobacco, there are potential risks to non-users, especially susceptible young adults. Different types of messaging that include information about absolute risk and addiction, risks of ONPs relative to cigarettes and e-cigarettes, ability to use ONPs instead of cigarettes/e-cigarettes (switching), and the potential benefits of doing so and potential benefits of switching to ONPs may be more or less effective in communicating risk for young adults.

Key Dates

First listed
Jul 14, 2026
Start date
Aug 1, 2025
Status verified
Jul 2026
Primary completion
Dec 29, 2025
Completion
Dec 29, 2025

Study Design

Enrollment
607 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Arm I (absolute risk of ONPs)
    Participants receive messaging regarding absolute risk and addiction beliefs. Participants engage with the content at their discretion.
  • Experimental: Arm II (efficacy of ONPs)
    Participants receive messaging regarding self and response efficacy of ONPs. Participants engage with the content at their discretion.
  • Experimental: Arm III (relative risk of ONPs)
    Participants receive messaging regarding risk of ONPs relative to cigarettes and e-cigarettes. Participants engage with the content at their discretion.
  • Experimental: Arm IV (Switching to ONPs)
    Participants receive messaging regarding switching to ONPs. Participants engage with the content at their discretion.
  • Active Comparator: Arm V (no messaging)
    Participants do not receive messaging.

Primary Outcome Measure

Perceived Message Effectiveness [ Time Frame: This assessment is administered immediately after participants view study messages. ]

Locations (1)

FacilityCityStateZIPSite coordinators
Ohio State University Comprehensive Cancer CenterColumbusOhio43210-

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By research site
Ohio State University Comprehensive Cancer Center· Columbus, OH

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