Serum Fetuin-A and COMP Levels in Knee Osteoarthritis

Sponsor
Antalya Training and Research Hospital
Study ID
NCT07706569
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Accepted

Study Details

The purpose of this study is to investigate the relationship between the clinical and radiographic severity of knee osteoarthritis (OA) and the serum levels of specific biomarkers, namely Fetuin-A and Cartilage Oligomeric Matrix Protein (COMP). Osteoarthritis is a degenerative joint disease characterized by cartilage breakdown and low-grade inflammation. Investigating these biomarkers may help healthcare providers better understand the disease pathology, potentially leading to earlier diagnosis and improved tracking of disease progression. The study will compare two distinct groups: a patient group consisting of 120 individuals diagnosed with Grade 2-4 knee osteoarthritis, and a control group of 60 age- and sex-matched healthy volunteers with no history of joint disorders. Participants will undergo radiographic evaluations using the Kellgren-Lawrence classification system, alongside clinical and functional assessments, including pain severity scales, mobility metrics, and functional questionnaires. Fasting blood samples will be collected from all participants to measure serum Fetuin-A and COMP levels via laboratory analysis, and the Systemic Inflammation Response Index (SIRI) will be calculated. The collected data will be statistically analyzed to determine if biomarker levels significantly correlate with the severity of knee joint degeneration and functional impairment.

Key Dates

First listed
Jul 15, 2026
Start date
Apr 1, 2026
Status verified
Jul 2026
Primary completion
Aug 30, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
180 participants (estimated)

Arms

  • Arm: Knee Osteoarthritis Group
    120 patients diagnosed with primary knee osteoarthritis (Grade 2-4 according to Kellgren-Lawrence classification, 40 patients from each grade).
  • Arm: Healthy Control Group
    60 age- and sex-matched healthy volunteers without any knee pain, history of joint disease, or systemic inflammatory conditions.

Primary Outcome Measure

Serum Fetuin-A Levels [ Time Frame: Baseline (At the time of enrollment / single time point measurement) ]

Central Contacts

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