Musculoskeletal disorders Clinical Trials

Recruiting musculoskeletal disorders studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat musculoskeletal disorders. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting musculoskeletal disorders studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting musculoskeletal disorders trials

Within

Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care

for Chronic Pain

1 site in Aurora

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07456150·Phase 1

Estradiol Supplementation and Rotator Cuff Repair

for Rotator Cuff Tears

Sponsor: University of Utah

Sex: Female·Age: 50 - 80

Code: NCT06318403·Phase 2

Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis

for Knee Osteoarthritis

2 sites in Irvine

Sponsor: Syntr Health Technologies, Inc.

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05526898

Therapeutic Exercise and Education for Low Back Pain

for Low Back Pain

Sponsor: University of Valladolid

Sex: All·Age: 18+

Code: NCT07713082

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

FIBROmyalgia: Somatic Tracking and Exercise Program Study

for Fibromyalgia (FM)

Sponsor: University of Tromso

Sex: All·Age: 18 - 65

Code: NCT06922747

Zynrelef Versus Adductor Canal Block

for Knee Osteoarthritis

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07216586·Phase 4

AI and Computer Vision-Assisted Telerehabilitation in Fibromyalgia: The FibroIA 2.0 Trial

for Fibromyalgia

Sponsor: Instituto Neurociencia Del Dolor

Sex: All·Age: 18+

Code: NCT07674485

Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty

for Knee Osteoarthritis

Sponsor: Loyola University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06486714

Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 45 - 70

Code: NCT07391449

Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers

for Systemic Lupus Erythematosus

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 4 - 75

Code: NCT07791199·Phase 3

Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions

for Knee Osteoarthritis

Sponsor: Dubai Health Authority

Sex: All·Age: 18+

Code: NCT06000670

Apremilast and Adalimumab in Psoriatic Arthritis Patients

for Psoriatic Arthritis

Sponsor: Tanta University

Sex: All·Age: 18 - 70

Code: NCT07398651

IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success

for Knee Osteoarthritis

1 site in Los Angeles

Sponsor: Lucas R. Cusumano, MD

Sex: All·Age: 40+

Code: NCT07494838

Safety and Tolerability of a Single Intravenous Infusion of BX-U001 in Refractory Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Baylx Inc.

Sex: All·Age: 18 - 70

Code: NCT03828344·Phase 1

Elucidating the Central Mechanisms of Action for Green Light Therapy in Managing Chronic Pain

for Fibromyalgia

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18+

Code: NCT05569486

Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Boston University Charles River Campus

Sex: All·Age: 50 - 85

Code: NCT07537114

A Study Evaluating the Safety, Tolerability, and Activity of ICM-203 in Subjects With Knee Osteoarthritis.

for Osteoarthritis, Knee

Sponsor: ICM Co. Ltd.

Sex: All·Age: 50 - 80

Code: NCT05454566·Phase 1, Phase 2

Effect of Kinesio Taping Versus Myofascial Release on Menstrual Low Back Pain

for Low Back Pain

Sponsor: Cairo University

Sex: Female·Age: 18 - 25·Accepts healthy volunteers

Code: NCT06280989

The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.

for Rehabilitation

Sponsor: King Saud University

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT07640529

Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis

for Knee Osteoarthritis

1 site in West Haven

Sponsor: Yale University

Sex: All·Age: 40+

Code: NCT07189585·Phase 2

Empowered Relief for Caregivers

for Chronic Pain

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07636980

Advancing Online Psychology Tools for Chronic Pain

for Fibromyalgia

Sponsor: Women's College Hospital

Sex: All·Age: 18+

Code: NCT07659873

Serum Asprosin, Metabolic Syndrome, and Cardiometabolic Risk in Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07793747

Disease Impact and Its Correlation With Disease Activity in Psoriatic Arthritis

for Psoriatic Arthritis

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07793773

Subclinical Hypothyroidism and Disease Activity in Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07793786

taVNS Treatment for Fibromyalgia

for Fibromyalgia

1 site in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT04777500

NANOVAE to Treat Knee Osteoarthritis (KOA)

for Knee Osteoarthritis

1 site in Chesterfield

Sponsor: Nova Vita Laboratory

Sex: All·Age: 21 - 75

Code: NCT06606561·Phase 1, Phase 2

Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy

for Cerebral Palsy (CP)

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07585292

Impact of the Receptive Music Intervention Tool (MUSIC CARE©) on Changes in the Functional Abilities of Patients With Chronic Low Back Pain

for Low Back Pain

Sponsor: LNA SANTE

Sex: All·Age: 18+

Code: NCT07731204

Development and Evaluation of the Effectiveness of the SMART-HAND Protocol for Hand Rehabilitation in Patients With Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18+

Code: NCT07754552

Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee Osteoarthritis

for Osteoarthritis, Knee

Sponsor: Federal University of São Paulo

Sex: All·Age: 18 - 80

Code: NCT07766330

Virtual Tai Chi for Chronic Low Back Pain (Spine 2027)

for Low Back Pain

1 site in Valhalla

Sponsor: New York Medical College

Sex: All·Age: 18+

Code: NCT07772154

Effects of Different Collagen Formulations on Knee Osteoarthritis

for Osteoarthritis, Knee

Sponsor: Cihangir Türemiş

Sex: All·Age: 35 - 65

Code: NCT07800780

Effect of Dry Needling Plus Vibration on Myofascial Trigger Points in Individuals With Nonspecific Low Back Pain

for Low Back Pain

Sponsor: Universidad de Zaragoza

Sex: All·Age: 35 - 65

Code: NCT06527339

Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy

for Chronic Pain

Sponsor: Universidad Autonoma de Madrid

Sex: All·Age: 18+

Code: NCT07451587

Disulfiram in Rheumatoid Arthritis

for Rheumatoid Arthritis

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 75

Code: NCT07534332·Phase 2

The Effectiveness of High-intensity Laser Therapy After Arthroscopic Shoulder Rotator Cuff Repair.

for Rotator Cuff Tears

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 30 - 70

Code: NCT07568288

Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Utku Gürhan

Sex: All·Age: 40 - 60

Code: NCT07617233

Analgesic Efficacy of Multisite rTMS in Fibromyalgia Patients

for Fibromyalgia

Sponsor: Hospital Ambroise Paré Paris

Sex: All·Age: 18 - 80

Code: NCT07642882

Apply to this trial

Multidisciplinary Health Monitoring for Esports Players

for Musculoskeletal Pain

Sponsor: Yeditepe University

Sex: Male·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07665333

Spinery Basivertebral Nerve Ablation for Vertebrogenic Chronic Low Back Pain

for Low Back Pain

Sponsor: Axon srl

Sex: All·Age: 25+

Code: NCT07696507

Intra Articular Injection of Peripheral Blood Mononuclear Cells for Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: DuoGenic StemCells Corporation (DGSC)

Sex: All·Age: 40 - 80

Code: NCT07703280·Phase 2, Phase 3

Prevalence of Fibromyalgia in Patients With Plaque Psoriasis

for Plaque Psoriasis

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07773766

The Effect of Connective Tissue Massage on Pressure Pain Threshold in Fibromyalgia

for Fibromyalgia

Sponsor: Ankara Yildirim Beyazıt University

Sex: Female·Age: 18 - 65

Code: NCT07791134

MDMA-assisted Therapy for Fibromyalgia

for Fibromyalgia

1 site in Charlestown

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 21 - 65

Code: NCT06066853·EARLY_Phase 1

Apply to this trial

The Association Between Amputation Level and Chronic Low Back Pain After Combat-Related Amputation

for Low Back Pain

Sponsor: Ukrainian Society of Regional Anesthesia and Pain Therapy

Sex: All·Age: 18 - 50

Code: NCT07626294

A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body

for Rheumatoid Arthritis

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07649265·Phase 1

Effects of Box Breathing Exercise in Patients With Fibromyalgia

for Fibromyalgia

Sponsor: Artvin Coruh University

Sex: All·Age: 18+

Code: NCT07722923

Boosting Exercise Adherence in Knee Osteoarthritis

for Osteoarthritis, Knee

1 site in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07219732

A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune Diseases

for Systemic Lupus Erythematosus

Sponsor: Pfizer

Sex: All·Age: 18 - 70

Code: NCT07782450·Phase 1, Phase 2

Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.

for Knee Osteoarthritis

1 site in Bethesda

Sponsor: Walter Reed National Military Medical Center

Sex: All·Age: 18+

Code: NCT07151417·Phase 2, Phase 3

Apply to this trial

Analgesic Effect of a Biophotonic Foot Massage Cream

for Musculoskeletal Pain

Sponsor: University of Seville

Sex: All·Age: 18+

Code: NCT07501273

Brain Connectivity and Perceptive Surfaces in Chronic Low Back Pain (SUPER-RMNf)

for Low Back Pain

Sponsor: G. d'Annunzio University

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07568353

Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain

for Knee Osteoarthritis

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 55 - 80

Code: NCT07698418

Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research

for Pericarditis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07737470

Efficacy & Safety of Fluoroquinolone-Based Brucellosis Regimens (BRUCE)

for Brucellosis

Sponsor: The First Affiliated Hospital of Shihezi University

Sex: All·Age: 16 - 75

Code: NCT07779629

Biomarkers to Predict Rotator Cuff Repair Healing on Postoperative MRI

for Rotator Cuff Tears

1 site in Iowa City

Sponsor: Joseph W. Galvin

Sex: All·Age: 18 - 99

Code: NCT07781553

Apply to this trial

Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women

for Chronic Pain

Sponsor: Associação Pan-Americana Multidisciplinar de Endocanabinologia

Sex: Female·Age: 45 - 80

Code: NCT07783295·Phase 2

Efficacy and Safety of Telitacicept in the Treatment of Refractory Rheumatoid Arthritis

for Difficult-to-treat Rheumatoid Arthritis

Sponsor: Peking University People's Hospital

Sex: All·Age: 18+

Code: NCT07796516·Phase 2

Apply to this trial

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Musculoskeletal disorders clinical trials — common questions

Are musculoskeletal disorders clinical trials free to join?

Yes. Participating in a musculoskeletal disorders clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a musculoskeletal disorders clinical trial?

Each musculoskeletal disorders study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a musculoskeletal disorders trial near me?

Use the location controls above. We'll show recruiting musculoskeletal disorders trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many musculoskeletal disorders trials are recruiting right now?

We're currently tracking roughly 330 recruiting musculoskeletal disorders trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Musculoskeletal disorders trials by city

Chicago, IL Birmingham, AL Ann Arbor, MI Boston, MA Gainesville, FL Cleveland, OH La Jolla, CA Los Angeles, CA Palo Alto, CA Aurora, CO Irvine, CA San Diego, CA

Conditions in this area

Knee osteoarthritis Osteoarthritis (other)Rotator cuff tears Low back pain Fibromyalgia Musculoskeletal pain Rheumatoid arthritis Psoriatic arthritis