Musculoskeletal disorders Clinical Trials

Recruiting musculoskeletal disorders studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat musculoskeletal disorders. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting musculoskeletal disorders studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting musculoskeletal disorders trials

Within

Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care

for Chronic Pain

1 site in Aurora

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07456150·Phase 1

Estradiol Supplementation and Rotator Cuff Repair

for Rotator Cuff Tears

Sponsor: University of Utah

Sex: Female·Age: 50 - 80

Code: NCT06318403·Phase 2

Therapeutic Exercise and Education for Low Back Pain

for Low Back Pain

Sponsor: University of Valladolid

Sex: All·Age: 18+

Code: NCT07713082

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

FIBROmyalgia: Somatic Tracking and Exercise Program Study

for Fibromyalgia (FM)

Sponsor: University of Tromso

Sex: All·Age: 18 - 65

Code: NCT06922747

Zynrelef Versus Adductor Canal Block

for Knee Osteoarthritis

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07216586·Phase 4

AI and Computer Vision-Assisted Telerehabilitation in Fibromyalgia: The FibroIA 2.0 Trial

for Fibromyalgia

Sponsor: Instituto Neurociencia Del Dolor

Sex: All·Age: 18+

Code: NCT07674485

Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 45 - 70

Code: NCT07391449

Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions

for Knee Osteoarthritis

Sponsor: Dubai Health Authority

Sex: All·Age: 18+

Code: NCT06000670

Apremilast and Adalimumab in Psoriatic Arthritis Patients

for Psoriatic Arthritis

Sponsor: Tanta University

Sex: All·Age: 18 - 70

Code: NCT07398651

Safety and Tolerability of a Single Intravenous Infusion of BX-U001 in Refractory Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Baylx Inc.

Sex: All·Age: 18 - 70

Code: NCT03828344·Phase 1

Elucidating the Central Mechanisms of Action for Green Light Therapy in Managing Chronic Pain

for Fibromyalgia

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18+

Code: NCT05569486

A Study Evaluating the Safety, Tolerability, and Activity of ICM-203 in Subjects With Knee Osteoarthritis.

for Osteoarthritis, Knee

Sponsor: ICM Co. Ltd.

Sex: All·Age: 50 - 80

Code: NCT05454566·Phase 1, Phase 2

Effect of Kinesio Taping Versus Myofascial Release on Menstrual Low Back Pain

for Low Back Pain

Sponsor: Cairo University

Sex: Female·Age: 18 - 25·Accepts healthy volunteers

Code: NCT06280989

Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis

for Knee Osteoarthritis

1 site in West Haven

Sponsor: Yale University

Sex: All·Age: 40+

Code: NCT07189585·Phase 2

Empowered Relief for Caregivers

for Chronic Pain

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07636980

Advancing Online Psychology Tools for Chronic Pain

for Fibromyalgia

Sponsor: Women's College Hospital

Sex: All·Age: 18+

Code: NCT07659873

taVNS Treatment for Fibromyalgia

for Fibromyalgia

1 site in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT04777500

NANOVAE to Treat Knee Osteoarthritis (KOA)

for Knee Osteoarthritis

1 site in Chesterfield

Sponsor: Nova Vita Laboratory

Sex: All·Age: 21 - 75

Code: NCT06606561·Phase 1, Phase 2

Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy

for Cerebral Palsy (CP)

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07585292

Effect of Dry Needling Plus Vibration on Myofascial Trigger Points in Individuals With Nonspecific Low Back Pain

for Low Back Pain

Sponsor: Universidad de Zaragoza

Sex: All·Age: 35 - 65

Code: NCT06527339

Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy

for Chronic Pain

Sponsor: Universidad Autonoma de Madrid

Sex: All·Age: 18+

Code: NCT07451587

The Effectiveness of High-intensity Laser Therapy After Arthroscopic Shoulder Rotator Cuff Repair.

for Rotator Cuff Tears

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 30 - 70

Code: NCT07568288

Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Utku Gürhan

Sex: All·Age: 40 - 60

Code: NCT07617233

Analgesic Efficacy of Multisite rTMS in Fibromyalgia Patients

for Fibromyalgia

Sponsor: Hospital Ambroise Paré Paris

Sex: All·Age: 18 - 80

Code: NCT07642882

Apply to this trial

Multidisciplinary Health Monitoring for Esports Players

for Musculoskeletal Pain

Sponsor: Yeditepe University

Sex: Male·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07665333

Spinery Basivertebral Nerve Ablation for Vertebrogenic Chronic Low Back Pain

for Low Back Pain

Sponsor: Axon srl

Sex: All·Age: 25+

Code: NCT07696507

Intra Articular Injection of Peripheral Blood Mononuclear Cells for Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: DuoGenic StemCells Corporation (DGSC)

Sex: All·Age: 40 - 80

Code: NCT07703280·Phase 2, Phase 3

The Association Between Amputation Level and Chronic Low Back Pain After Combat-Related Amputation

for Low Back Pain

Sponsor: Ukrainian Society of Regional Anesthesia and Pain Therapy

Sex: All·Age: 18 - 50

Code: NCT07626294

A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body

for Rheumatoid Arthritis

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07649265·Phase 1

Analgesic Effect of a Biophotonic Foot Massage Cream

for Musculoskeletal Pain

Sponsor: University of Seville

Sex: All·Age: 18+

Code: NCT07501273

Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain

for Knee Osteoarthritis

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 55 - 80

Code: NCT07698418

Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Boston University Charles River Campus

Sex: All·Age: 50 - 85

Code: NCT07537114

Repeated Injections of Adipose-derived Stem Cells in Rotator Cuff Tears

for Rotator Cuff Tears

Sponsor: University of Southern Denmark

Sex: All·Age: 30 - 69

Code: NCT07592936·Phase 1, Phase 2

The BRIDGE Pain Study

for Juvenile Idiopathic Arthritis (JIA)

1 site in Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 14 - 26

Code: NCT07602595

Apply to this trial

Impact of Major Ozone Autohemotherapy on Sarcopenia Parameters in Fibromyalgia

for Fibromyalgia

Sponsor: Sakarya University

Sex: All·Age: 18 - 65

Code: NCT07680621

Device-Based vs Manual Sensory Training in Low Back Pain

for Low Back Pain

Sponsor: Medipol University

Sex: All·Age: 25 - 45

Code: NCT07277803

Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain

for Hyperthermia

Sponsor: Bern University of Applied Sciences

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07101978

Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT

for Chronic Low Back Pain

2 sites incl. Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: 22+

Code: NCT07158567·Phase 3

Comparing Yoga Nidra, Yoga, and Control Condition on Pain in Individuals With Chronic Low Back Pain

for Low Back Pain

1 site in Orlando

Sponsor: University of Central Florida

Sex: All·Age: 18 - 65

Code: NCT07543835

Comparison of Traditional, Synchronous, and Asynchronous Telerehabilitation in Office Workers With Chronic Nonspecific Low Back Pain

for Chronic Non-Specific Low Back Pain

Sponsor: Istanbul Aydın University

Sex: All·Age: 18 - 65

Code: NCT07700589

Effect of Tergase Injection on Reducing Edema After Bilateral Total Knee Arthroplasty

for Osteoarthritis, Knee

Sponsor: Man Soo Kim

Sex: All·Age: 60 - 85

Code: NCT07705165

Pain & Reward Neuromodulation of CNS Circuits

for Fibromyalgia Syndrome

Sponsor: Duke University

Sex: Female·Age: 18+

Code: NCT07525063

Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty

for Knee Arthritis

3 sites in Atlanta

Sponsor: Emory University

Sex: All·Age: 18 - 95

Code: NCT07624526·Phase 4

Neuroscience Education and Spinal Manipulation on Health Locus of Control in Low Back Pain

for Low Back Pain

Sponsor: Centro Universitário Augusto Motta

Sex: All·Age: 18 - 60

Code: NCT07639216

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain

for Chronic Pain

36 sites incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07641504·Phase 2

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

for Osteoarthritis, Knee

36 sites incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 40+

Code: NCT07641517·Phase 2

Neurolyser XR for the Treatment of Sacroiliitis

for Sacroiliitis

Sponsor: Federico II University

Sex: All·Age: 18 - 80

Code: NCT07647757

Robotic-Assisted Versus Conventional Total Knee Arthroplasty With Virtual Home-Based Rehabilitation

for Osteoarthritis, Knee

Sponsor: Mark Hurworth

Sex: All·Age: 40+

Code: NCT07716267

Shock Wave Treatment in Patients With Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Guadarrama Hospital

Sex: All·Age: 18+

Code: NCT07125430

The Role of Resilience for Physical Functioning of Patients With Fibromyalgia Syndrome Using the 6-Min Walk Test

for Fibromyalgia

Sponsor: University of Florida

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07611539

Standard Versus Novel RFA for Chronic Knee Pain in Osteoarthritis

for Osteoarthritis, Knee

Sponsor: Lawson Research Institute of St. Joseph's

Sex: All·Age: All ages

Code: NCT07674082

A Phase 1, First-in-Human Study of CND319 in Healthy Participants and Patients With Rheumatic Diseases

for Healthy Participants Study

Sponsor: Candid Therapeutics

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07712939·Phase 1

Apply to this trial

Natrunix in Combination With Methotrexate for Rheumatoid Arthritis Treatment

for Rheumatoid Arthritis

Sponsor: XBiotech, Inc.

Sex: All·Age: 18+

Code: NCT06590090·Phase 2

Regenerative Medicine for Joint Hypermobility and Instability

for Ehlers-Danlos Syndrome Hypermobility Type (hEDS)

Sponsor: Manhattan Pain Medicine, PLLC

Sex: All·Age: 18+

Code: NCT07688096·Phase 1, Phase 2

Preoperative Versus Postoperative Interscalene Block in Arthroscopic Rotator Cuff Repair

for Rotator Cuff Tear Repair

Sponsor: Istinye University

Sex: All·Age: 18+

Code: NCT07689448

Genicular Artery Embolization for Knee Osteoarthritis

for Osteoarthritis

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 40 - 80

Code: NCT07537153

Apply to this trial

Kinetic Control Training Versus Core Stability Exercises on Proprioception and Spatiotemporal Gait Parameters in Chronic Non-specific Low Back Pain

for Low Back Pain

Sponsor: Cairo University

Sex: All·Age: 18 - 45

Code: NCT07683676

The Effect of Lipedema on Knee Osteoarthritis

for Lipedema

Sponsor: Izmir Democracy University

Sex: Female·Age: 30 - 65

Code: NCT07575555

Apply to this trial

Phase 1b/2 Study of IV Sarilumab in Adult With RA

for Rheumatoid Arthritis

2 sites incl. Hollywood

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT07704580·Phase 1, Phase 2

Apply to this trial

Musculoskeletal disorders clinical trials — common questions

Are musculoskeletal disorders clinical trials free to join?

Yes. Participating in a musculoskeletal disorders clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a musculoskeletal disorders clinical trial?

Each musculoskeletal disorders study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a musculoskeletal disorders trial near me?

Use the location controls above. We'll show recruiting musculoskeletal disorders trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many musculoskeletal disorders trials are recruiting right now?

We're currently tracking roughly 330 recruiting musculoskeletal disorders trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Musculoskeletal disorders trials by city

Chicago, IL Birmingham, AL Boston, MA Ann Arbor, MI Gainesville, FL La Jolla, CA Palo Alto, CA Aurora, CO Cleveland, OH Los Angeles, CA San Francisco, CA Sacramento, CA

Conditions in this area

Knee osteoarthritis Osteoarthritis (other)Rotator cuff tears Low back pain Fibromyalgia Musculoskeletal pain Rheumatoid arthritis Psoriatic arthritis