Orthopedics Clinical Trials

Recruiting orthopedics studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat orthopedics. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting orthopedics studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting orthopedics trials

Within

Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial

for Spinal Cord Injury

Sponsor: XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.

Sex: All·Age: 18 - 65

Code: NCT06974968·Phase 2

Estradiol Supplementation and Rotator Cuff Repair

for Rotator Cuff Tears

Sponsor: University of Utah

Sex: Female·Age: 50 - 80

Code: NCT06318403·Phase 2

Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury

for Spinal Cord Injuries

1 site in Cambridge

Sponsor: Randy Trumbower, PT, PhD

Sex: All·Age: 18 - 75

Code: NCT05217498·Phase 1, Phase 2

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

Zynrelef Versus Adductor Canal Block

for Knee Osteoarthritis

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07216586·Phase 4

Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 45 - 70

Code: NCT07391449

NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI

for Spinal Cord Injuries

Sponsor: Simon Fraser University

Sex: All·Age: 19 - 80

Code: NCT05635851·Phase 2

Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions

for Knee Osteoarthritis

Sponsor: Dubai Health Authority

Sex: All·Age: 18+

Code: NCT06000670

Assessment of Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments

for Stroke

Sponsor: Motion Informatics LTD

Sex: All·Age: 18 - 80

Code: NCT07396922

A Study Evaluating the Safety, Tolerability, and Activity of ICM-203 in Subjects With Knee Osteoarthritis.

for Osteoarthritis, Knee

Sponsor: ICM Co. Ltd.

Sex: All·Age: 50 - 80

Code: NCT05454566·Phase 1, Phase 2

Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis

for Knee Osteoarthritis

1 site in West Haven

Sponsor: Yale University

Sex: All·Age: 40+

Code: NCT07189585·Phase 2

Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation: Effect on Imaging and Serum Biomarkers of Skeletal Muscle Mass and Bone Strength.

for Spinal Cord Injury

2 sites incl. West Orange

Sponsor: VA Office of Research and Development

Sex: All·Age: 21 - 60

Code: NCT07418398

Treatment of Depression Post-SCI

for Depression

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70

Code: NCT04263285

Apply to this trial

Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury

for Spinal Cord Injuries

2 sites in Miami

Sponsor: University of Miami

Sex: All·Age: 22 - 70

Code: NCT07109804

Apply to this trial

NANOVAE to Treat Knee Osteoarthritis (KOA)

for Knee Osteoarthritis

1 site in Chesterfield

Sponsor: Nova Vita Laboratory

Sex: All·Age: 21 - 75

Code: NCT06606561·Phase 1, Phase 2

Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury

for Spinal Cord Injury

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07588711

Development of a Pain Rehabilitation Program for Chronic Pain After SCI

for Spinal Cord Injuries

Sponsor: Umeå University

Sex: All·Age: 18+

Code: NCT07634796

The Effectiveness of High-intensity Laser Therapy After Arthroscopic Shoulder Rotator Cuff Repair.

for Rotator Cuff Tears

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 30 - 70

Code: NCT07568288

Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Utku Gürhan

Sex: All·Age: 40 - 60

Code: NCT07617233

Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury

for Spinal Cord Injuries

1 site in West Orange

Sponsor: Kessler Foundation

Sex: All·Age: 18 - 75

Code: NCT07674511

Intra Articular Injection of Peripheral Blood Mononuclear Cells for Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: DuoGenic StemCells Corporation (DGSC)

Sex: All·Age: 40 - 80

Code: NCT07703280·Phase 2, Phase 3

Spinal Neurorehabilitation for Veterans With SCI

for Spinal Cord Injuries

1 site in Sacramento

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07222046

Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain

for Knee Osteoarthritis

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 55 - 80

Code: NCT07698418

Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Boston University Charles River Campus

Sex: All·Age: 50 - 85

Code: NCT07537114

Repeated Injections of Adipose-derived Stem Cells in Rotator Cuff Tears

for Rotator Cuff Tears

Sponsor: University of Southern Denmark

Sex: All·Age: 30 - 69

Code: NCT07592936·Phase 1, Phase 2

Innovative Brain-Computer Interface for People With Spinal Cord Injury

for Spinal Cord Injury

Sponsor: UMC Utrecht

Sex: All·Age: 18 - 70

Code: NCT07640711

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Empowerment Program to Reduce Treatment of Asymptomatic Bacteriuria in Veterans With Spinal Cord Injury

for Spinal Cord Injury

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07430904

Xo-Motion R Exoskeleton in SCI-Adoption Study

for Spinal Cord Injury

Sponsor: University of Alberta

Sex: All·Age: 18+

Code: NCT07380516

Fermented Foods and Bowel Health in SCI

for Spinal Cord Injury

1 site in Columbus

Sponsor: Ohio State University

Sex: All·Age: 18 - 70

Code: NCT07640152

Effect of Tergase Injection on Reducing Edema After Bilateral Total Knee Arthroplasty

for Osteoarthritis, Knee

Sponsor: Man Soo Kim

Sex: All·Age: 60 - 85

Code: NCT07705165

The Effects of Eccentric Compared to Standard Strength Training in Primary Spinal Cord Injury Rehabilitation

for Spinal Cord Injury

Sponsor: Swiss Paraplegic Research, Nottwil

Sex: All·Age: 18+

Code: NCT06905470

Efficacy of a Wearable Noninvasive Neuromodulation Device

for Spinal Cord Injuries

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07171489

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Dorsal Root Ganglion Stimulation After Lower Motor Neuron Damage

for Spinal Cord Injuries

1 site in Rochester

Sponsor: Peter J. Grahn, Ph.D.

Sex: All·Age: 18 - 70

Code: NCT07619300

Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty

for Knee Arthritis

3 sites in Atlanta

Sponsor: Emory University

Sex: All·Age: 18 - 95

Code: NCT07624526·Phase 4

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

for Osteoarthritis, Knee

36 sites incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 40+

Code: NCT07641517·Phase 2

Robotic-Assisted Versus Conventional Total Knee Arthroplasty With Virtual Home-Based Rehabilitation

for Osteoarthritis, Knee

Sponsor: Mark Hurworth

Sex: All·Age: 40+

Code: NCT07716267

Shock Wave Treatment in Patients With Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Guadarrama Hospital

Sex: All·Age: 18+

Code: NCT07125430

Kinesio Taping for Neurogenic Bowel Dysfunction in Spinal Cord Injury

for Neurogenic Bowel Dysfunction

Sponsor: Pamukkale University

Sex: All·Age: 18+

Code: NCT07705984

Standard Versus Novel RFA for Chronic Knee Pain in Osteoarthritis

for Osteoarthritis, Knee

Sponsor: Lawson Research Institute of St. Joseph's

Sex: All·Age: All ages

Code: NCT07674082

ZEPU-AI3 Lower Limb Feedback Robot Training Study

for Stroke

Sponsor: Bangladesh Medical University

Sex: All·Age: 18 - 70

Code: NCT07705906

Preoperative Versus Postoperative Interscalene Block in Arthroscopic Rotator Cuff Repair

for Rotator Cuff Tear Repair

Sponsor: Istinye University

Sex: All·Age: 18+

Code: NCT07689448

Genicular Artery Embolization for Knee Osteoarthritis

for Osteoarthritis

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 40 - 80

Code: NCT07537153

Apply to this trial

Combined Magnetic Stimulation and Ultrasound for Detrusor Overactivity in SCI

for Spinal Cord Injuries

Sponsor: Shengjing Hospital

Sex: All·Age: 18 - 80

Code: NCT07704268

The Effect of Lipedema on Knee Osteoarthritis

for Lipedema

Sponsor: Izmir Democracy University

Sex: Female·Age: 30 - 65

Code: NCT07575555

Apply to this trial

A Clinical Study of a Fully Implanted, Wireless and Functional BCI for Upper-Limb Functional Replacement in Tetraplegia Due to Spinal Cord Injury: Efficacy and Safety

for Spinal Cord Injury

Sponsor: NeuroXess Technology (shanghai) Co.,Ltd.

Sex: All·Age: 18 - 65

Code: NCT07720882

Apply to this trial

Optimization of Adaptive Rowing Seating

for Spinal Cord Diseases

2 sites incl. Minneapolis

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07099625

Self-managed vs Supervised Exercise for Knee OA

for Knee Osteoarthritis

Sponsor: Marius Henriksen

Sex: All·Age: 45+

Code: NCT07210931

Boosting Exercise Adherence in Knee Osteoarthritis

for Osteoarthritis, Knee

1 site in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07219732

Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury

for Spinal Cord Injury

Sponsor: Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal

Sex: All·Age: 16+

Code: NCT07375745

MECHANICAL TRACTION APPLIED BEFORE VERSUS AFTER THERAPEUTIC EXERCISES IN PRIMARY KNEE OSTEOARTHRITIS

for Knee Osteoarthritis

Sponsor: Cairo University

Sex: All·Age: 50 - 65

Code: NCT07613749

Post-op Prednisone and Glucose Monitoring in TKA

for Osteoarthritis

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT07630896·Phase 4

Effects of Sahrmann's Approach Versus Conventional Treatment Oin Patients With Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Riphah International University

Sex: All·Age: 40 - 60

Code: NCT07642258

Health Aid for Knee Osteoarthritis

for Knee Osteoarthritis

1 site in Austin

Sponsor: David Ring

Sex: All·Age: 18 - 89

Code: NCT07669532

ACB and iPACK Blocks With Intravenous Dexamethasone and Perineural Dexmedetomidine in Total Knee Arthroplasty

for Knee Osteoarthritis

Sponsor: Poznan University of Medical Sciences

Sex: All·Age: 60 - 100

Code: NCT07677215

Effect of Blood Flow-restricted Exercise Frequency on Strength Recovery Following Incomplete SCI

for Spinal Cord Injury

1 site in Omaha

Sponsor: Quality Living, Inc.

Sex: All·Age: 19 - 75

Code: NCT07678437

Artificial Intelligence-Assisted Advanced Analysis of Knee Imaging and Outcome Prediction

for Degenerative Knee Disorders

Sponsor: National Taiwan University Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07721116

Apply to this trial

Treatment for Sexual Dysfunction in Women with Spinal Cord Injury

for Spinal Cord Injuries

Sponsor: Cristina Lirio

Sex: Female·Age: 18 - 60

Code: NCT05122325

IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success

for Knee Osteoarthritis

1 site in Los Angeles

Sponsor: Lucas R. Cusumano, MD

Sex: All·Age: 40+

Code: NCT07494838

Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

for Chronic Pain

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07639060

Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD

for Spinal Cord Injury

2 sites incl. Washington D.C.

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT07643974·EARLY_Phase 1

Orthopedics clinical trials — common questions

Are orthopedics clinical trials free to join?

Yes. Participating in a orthopedics clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a orthopedics clinical trial?

Each orthopedics study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a orthopedics trial near me?

Use the location controls above. We'll show recruiting orthopedics trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many orthopedics trials are recruiting right now?

We're currently tracking roughly 347 recruiting orthopedics trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Orthopedics trials by city

Chicago, IL Cleveland, OH Miami, FL Birmingham, AL Sacramento, CA Seattle, WA Ann Arbor, MI Aurora, CO Boston, MA Englewood, CO Los Angeles, CA Columbus, OH

Conditions in this area

Knee osteoarthritis Osteoarthritis (other)Rotator cuff tears Total knee replacement Spinal cord injury