Orthopedics Clinical Trials

Recruiting orthopedics studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat orthopedics. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting orthopedics studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting orthopedics trials

Within

Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial

for Spinal Cord Injury

Sponsor: XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.

Sex: All·Age: 18 - 65

Code: NCT06974968·Phase 2

Estradiol Supplementation and Rotator Cuff Repair

for Rotator Cuff Tears

Sponsor: University of Utah

Sex: Female·Age: 50 - 80

Code: NCT06318403·Phase 2

Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis

for Knee Osteoarthritis

2 sites in Irvine

Sponsor: Syntr Health Technologies, Inc.

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05526898

Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial

for Spinal Cord Injury

4 sites incl. Aurora

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT07742553·Phase 2, Phase 3

Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury

for Spinal Cord Injuries

1 site in Cambridge

Sponsor: Randy Trumbower, PT, PhD

Sex: All·Age: 18 - 75

Code: NCT05217498·Phase 1, Phase 2

Empowerment Program to Reduce Treatment of Asymptomatic Bacteriuria in Veterans With Spinal Cord Injury

for Spinal Cord Injury

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07430904

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

Zynrelef Versus Adductor Canal Block

for Knee Osteoarthritis

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07216586·Phase 4

Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty

for Knee Osteoarthritis

Sponsor: Loyola University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06486714

Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 45 - 70

Code: NCT07391449

NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI

for Spinal Cord Injuries

Sponsor: Simon Fraser University

Sex: All·Age: 19 - 80

Code: NCT05635851·Phase 2

Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions

for Knee Osteoarthritis

Sponsor: Dubai Health Authority

Sex: All·Age: 18+

Code: NCT06000670

Assessment of Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments

for Stroke

Sponsor: Motion Informatics LTD

Sex: All·Age: 18 - 80

Code: NCT07396922

IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success

for Knee Osteoarthritis

1 site in Los Angeles

Sponsor: Lucas R. Cusumano, MD

Sex: All·Age: 40+

Code: NCT07494838

Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Boston University Charles River Campus

Sex: All·Age: 50 - 85

Code: NCT07537114

A Study Evaluating the Safety, Tolerability, and Activity of ICM-203 in Subjects With Knee Osteoarthritis.

for Osteoarthritis, Knee

Sponsor: ICM Co. Ltd.

Sex: All·Age: 50 - 80

Code: NCT05454566·Phase 1, Phase 2

The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.

for Rehabilitation

Sponsor: King Saud University

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT07640529

Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis

for Knee Osteoarthritis

1 site in West Haven

Sponsor: Yale University

Sex: All·Age: 40+

Code: NCT07189585·Phase 2

Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation: Effect on Imaging and Serum Biomarkers of Skeletal Muscle Mass and Bone Strength.

for Spinal Cord Injury

2 sites incl. West Orange

Sponsor: VA Office of Research and Development

Sex: All·Age: 21 - 60

Code: NCT07418398

Treatment of Depression Post-SCI

for Depression

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70

Code: NCT04263285

Apply to this trial

Effects of a Mobile App-Based Mindfulness Intervention in Persons With Spinal Cord Injury and Chronic Pain

for Spinal Cord Injuries

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06891989

Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury

for Spinal Cord Injuries

2 sites in Miami

Sponsor: University of Miami

Sex: All·Age: 22 - 70

Code: NCT07109804

Apply to this trial

Optimization of Adaptive Rowing Seating

for Spinal Cord Diseases

2 sites incl. Minneapolis

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07099625

iBCI Optimization for Veterans With Paralysis

for Spinal Cord Injury

1 site in Providence

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 80

Code: NCT05470478

NANOVAE to Treat Knee Osteoarthritis (KOA)

for Knee Osteoarthritis

1 site in Chesterfield

Sponsor: Nova Vita Laboratory

Sex: All·Age: 21 - 75

Code: NCT06606561·Phase 1, Phase 2

Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury

for Spinal Cord Injury

Sponsor: Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal

Sex: All·Age: 16+

Code: NCT07375745

Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury

for Spinal Cord Injury

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07588711

Development of a Pain Rehabilitation Program for Chronic Pain After SCI

for Spinal Cord Injuries

Sponsor: Umeå University

Sex: All·Age: 18+

Code: NCT07634796

Cardiovascular Autonomic Function After Resistance Training

for Spinal Cord Injury

Sponsor: Pusan National University Yangsan Hospital

Sex: All·Age: 19 - 85

Code: NCT07725952

Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee Osteoarthritis

for Osteoarthritis, Knee

Sponsor: Federal University of São Paulo

Sex: All·Age: 18 - 80

Code: NCT07766330

Effects of Different Collagen Formulations on Knee Osteoarthritis

for Osteoarthritis, Knee

Sponsor: Cihangir Türemiş

Sex: All·Age: 35 - 65

Code: NCT07800780

The Effectiveness of High-intensity Laser Therapy After Arthroscopic Shoulder Rotator Cuff Repair.

for Rotator Cuff Tears

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 30 - 70

Code: NCT07568288

Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Utku Gürhan

Sex: All·Age: 40 - 60

Code: NCT07617233

Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury

for Spinal Cord Injuries

1 site in West Orange

Sponsor: Kessler Foundation

Sex: All·Age: 18 - 75

Code: NCT07674511

Intra Articular Injection of Peripheral Blood Mononuclear Cells for Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: DuoGenic StemCells Corporation (DGSC)

Sex: All·Age: 40 - 80

Code: NCT07703280·Phase 2, Phase 3

Guided Laminectomy With Augmented Duroplasty for Acute Traumatic Spinal Cord Injury

for Spinal Cord Injury

Sponsor: Xuanwu Hospital, Beijing

Sex: All·Age: 18 - 80

Code: NCT07733401

NeuroRise: Intrathecal CE-1 Treatment for Traumatic SCI

for SCI - Spinal Cord Injury

1 site in Chicago

Sponsor: Cell Therapy LLC

Sex: All·Age: 18+

Code: NCT07739043·EARLY_Phase 1

VALSE: Integration of Neuromodulation and Exoskeleton Systems for Mobility in Individuals With Chronic Spinal Cord Injury

for Spinal Cord Injury

Sponsor: Ecole Polytechnique Fédérale de Lausanne

Sex: All·Age: 18+

Code: NCT07745686

Boosting Exercise Adherence in Knee Osteoarthritis

for Osteoarthritis, Knee

1 site in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07219732

Oral Tranexamic Acid After Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06894719·Phase 4

Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.

for Knee Osteoarthritis

1 site in Bethesda

Sponsor: Walter Reed National Military Medical Center

Sex: All·Age: 18+

Code: NCT07151417·Phase 2, Phase 3

Apply to this trial

Spinal Neurorehabilitation for Veterans With SCI

for Spinal Cord Injuries

1 site in Sacramento

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07222046

Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain

for Knee Osteoarthritis

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 55 - 80

Code: NCT07698418

Efficacy & Safety of Fluoroquinolone-Based Brucellosis Regimens (BRUCE)

for Brucellosis

Sponsor: The First Affiliated Hospital of Shihezi University

Sex: All·Age: 16 - 75

Code: NCT07779629

Biomarkers to Predict Rotator Cuff Repair Healing on Postoperative MRI

for Rotator Cuff Tears

1 site in Iowa City

Sponsor: Joseph W. Galvin

Sex: All·Age: 18 - 99

Code: NCT07781553

Apply to this trial

TTNS in SCI Patients With Neurogenic Detrusor Overactivity

for Spinal Cord Injuries

Sponsor: National University Hospital, Singapore

Sex: All·Age: 21 - 70

Code: NCT07785258

Repeated Injections of Adipose-derived Stem Cells in Rotator Cuff Tears

for Rotator Cuff Tears

Sponsor: University of Southern Denmark

Sex: All·Age: 30 - 69

Code: NCT07592936·Phase 1, Phase 2

Innovative Brain-Computer Interface for People With Spinal Cord Injury

for Spinal Cord Injury

Sponsor: UMC Utrecht

Sex: All·Age: 18 - 70

Code: NCT07640711

Apply to this trial

Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD

for Spinal Cord Injury

2 sites incl. Washington D.C.

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT07643974·EARLY_Phase 1

Effects of IMT on Cardiopulmonary Endurance and Functional Mobility in KOA

for Knee Osteoarthritis

Sponsor: Riphah International University

Sex: All·Age: 40 - 65

Code: NCT07738627

ZEPU-AI Series Limb Feedback Robot Training Study (ZEPUAISRCT)

for Stroke

Sponsor: Bangladesh Medical University

Sex: All·Age: 18 - 60

Code: NCT07749625

Unipolar Versus Bipolar Radiofrequency Ablation in Knee Osteoarthritis Pain

for Bipolar Radiofrequency Ablation

Sponsor: Tanta University

Sex: All·Age: 50+

Code: NCT07789340

Apply to this trial

Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis

for Knee Osteoarthritis

Sponsor: Cairo University

Sex: All·Age: 45 - 70

Code: NCT07774195

Diagnostic Accuracy of Triphasic Bone Scan and SPECT/CT in Foot and Ankle Osteoarthritis

for Osteoarthritis

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07784257

Phonophoresis With Bee Venom: Evaluating Its Efficacy in Managing Pain and Enhancing Mobility in Knee Osteoarthritis Patients

for Knee Osteoarthritis

Sponsor: Sinai University

Sex: All·Age: 40 - 75

Code: NCT07151300

Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients

for Knee Osteoarthritis

Sponsor: Munzur University

Sex: All·Age: 55+

Code: NCT07545447

Suprainguinal Fascia Iliaca Block vs. Adductor Canal Block for Analgesia After Total Knee Arthroplasty

for Arthroplasty

Sponsor: Bursa Yuksek Ihtisas Training and Research Hospital

Sex: All·Age: 45 - 100

Code: NCT07739108

Pre-emptive Insulin to Prevent High Glucose After a Knee Steroid Injection in Adults With Type 2 Diabetes

for Diabetes Mellitus, Type 2

Sponsor: Shifa International Hospital

Sex: All·Age: 40 - 80

Code: NCT07757464·Phase 1, Phase 2

Psilocybin to Treat Depression in Spinal Cord Injury

for Spinal Cord Injury

1 site in The Bronx

Sponsor: James J. Peters Veterans Affairs Medical Center

Sex: All·Age: 22+

Code: NCT07251491·Phase 1, Phase 2

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A Study of Econoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)

for Knee Osteoarthritis

Sponsor: Hangzhou Sciwind Biosciences Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07734311·Phase 3

Apply to this trial

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Orthopedics clinical trials — common questions

Are orthopedics clinical trials free to join?

Yes. Participating in a orthopedics clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a orthopedics clinical trial?

Each orthopedics study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a orthopedics trial near me?

Use the location controls above. We'll show recruiting orthopedics trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many orthopedics trials are recruiting right now?

We're currently tracking roughly 347 recruiting orthopedics trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Orthopedics trials by city

Chicago, IL Cleveland, OH Miami, FL Birmingham, AL Aurora, CO Sacramento, CA Seattle, WA Englewood, CO Gainesville, FL Los Angeles, CA Ann Arbor, MI Boston, MA

Conditions in this area

Knee osteoarthritis Osteoarthritis (other)Rotator cuff tears Total knee replacement Spinal cord injury