Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue

Sponsor
University of Las Palmas de Gran Canaria
Study ID
NCT07709234
Status
Not Yet Recruiting

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Conditions

  • Cognitive Dysfunction
  • Fatigue
  • Long COVID
  • Post-COVID Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Direct Current Stimulation — DEVICE
    Transcranial direct current stimulation will be delivered using a constant-current stimulator through surface electrodes placed over the scalp. The anode will be positioned over the left dorsolateral prefrontal cortex, corresponding to F3 according to the international 10-20 EEG system, and the cathode will be placed over the contralateral supraorbital region. Each session will be delivered at 2 mA for 20 minutes. Participants will complete 30 sessions.

Study Details

Long COVID can cause persistent symptoms such as fatigue, cognitive difficulties commonly described as brain fog, reduced exercise tolerance, and impaired quality of life. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that may help modulate brain activity in regions involved in cognition, fatigue, and executive function. The NEUROSTIM-LC study will evaluate the feasibility and potential effects of repeated tDCS sessions in adults with long COVID presenting fatigue and/or brain fog. Participants will receive 30 sessions of tDCS applied over the left dorsolateral prefrontal cortex. Assessments will be performed before and after the intervention to evaluate changes in quality of life, fatigue, cognitive function, brain metabolism, physical performance, autonomic function, sleep quality, psychological symptoms, respiratory function, and blood biomarkers.

Key Dates

First listed
Jul 16, 2026
Start date
Sep 15, 2026
Status verified
Jul 2026
Primary completion
Dec 22, 2027
Completion
Mar 1, 2028

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: tDCS Intervention
    Participants will receive 30 sessions of transcranial direct current stimulation applied over the left dorsolateral prefrontal cortex. Stimulation will be delivered at 2 mA for 20 minutes per session, once daily, five days per week, under supervision of trained healthcare professionals.

Primary Outcome Measure

Change in EuroQol 5-Dimension 5-Level Questionnaire Score [ Time Frame: Baseline and 3 days after completion of the 30-session tDCS intervention ]

Central Contacts

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