Does Erectile Dysfonction Allow to Evaluate Subendocardial Viability Among Treated Patients With Hypertension ?

Sponsor
Assistance Publique - Hôpitaux de Paris
Study ID
NCT07719790
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
MALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Erectile dysfunction (ED) is associated with subclinical atherosclerosis and may precede clinically apparent coronary artery disease by two to five years. It may therefore serve as an early warning sign of cardiovascular disease and help identify patients who could benefit from intensified cardiovascular risk-factor management. The subendocardial viability ratio (SEVR), also known as the Buckberg index, is obtained noninvasively from radial artery applanation tonometry. SEVR reflects the balance between myocardial oxygen supply and demand and has been associated with coronary flow reserve in patients with hypertension. The DEVISE study will compare SEVR between treated men with hypertension who have ED with those who do not. The study will also examine the associations between ED severity and arterial stiffness, central hemodynamics, exercise capacity, left ventricular mass, coronary artery calcium, high-sensitivity C-reactive protein, cardiovascular risk, and quality of life. The question addressed in our study is whether an alteration in subendocardial viability represents subclinical coronary disease associated with ED.

Key Dates

First listed
Jul 22, 2026
Start date
Jul 17, 2026
Status verified
Jul 2026
Primary completion
Jan 17, 2028
Completion
Jan 17, 2028

Study Design

Enrollment
120 participants (estimated)

Arms

  • Arm: Treated hypertensive men with erectile dysfunction
    Treated hypertensive men without erectile dysfunction
  • Arm: Patients with hypertension without erectile dysfunction

Primary Outcome Measure

Subendocardial viability ratio (SEVR) [ Time Frame: Once, during the day-hospital visit ]

Central Contacts

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