Vitamin D Status and Asthma Control, Pulmonary Function, and Oxidative Stress in Adults With Bronchial Asthma

Sponsor
Sinai University
Study ID
NCT07733635
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Asthma is a chronic inflammatory airway disease associated with variable airflow limitation and persistent respiratory symptoms. Vitamin D has been proposed as a potential biomarker related to immune regulation, asthma control, pulmonary function, and oxidative stress balance. This prospective cross-sectional observational study aims to investigate the association between serum 25-hydroxyvitamin D \[25(OH)D\] concentrations, asthma control, pulmonary function parameters, and erythrocyte oxidative stress biomarkers among Egyptian adults with bronchial asthma. A total of 200 adult asthma patients will be recruited from Abbassia Chest Hospital, Cairo, Egypt. Participants will undergo clinical assessment, Asthma Control Test (ACT), post-bronchodilator spirometry, serum vitamin D measurement, and oxidative stress biomarker assessment including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced glutathione (GSH). Participants will be categorized according to serum 25(OH)D concentrations into vitamin D deficient, insufficient, and sufficient groups. No intervention or treatment assignment will be performed. 5\. Detailed Description

Key Dates

First listed
Jul 29, 2026
Start date
Jul 26, 2026
Status verified
Jul 2026
Primary completion
Dec 30, 2026
Completion
Feb 25, 2027

Study Design

Enrollment
134 participants (estimated)

Arms

  • Arm: Vitamin D Deficient Group
    Adults with bronchial asthma and serum 25-hydroxyvitamin D concentrations below 20 ng/mL.
  • Arm: Vitamin D Insufficient Group
    Adults with bronchial asthma and serum 25-hydroxyvitamin D concentrations between 20 and 30 ng/mL.
  • Arm: Vitamin D Sufficient Group
    Adults with bronchial asthma and serum 25-hydroxyvitamin D concentrations above 30 ng/mL.

Primary Outcome Measure

Asthma Control Level Measured by Asthma Control Test (ACT) Score [ Time Frame: Single baseline assessment. ]

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