Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention

Conditions

• Schizophrenia Spectrum Disorders (SSD)

Eligibility Criteria

Sex

ALL

Age

9 Years - 19 Years

Healthy Volunteers

Accepted

Interventions

• Psychosocial intervention group — BEHAVIORAL
  Over 16 weeks, participants and their parent/legal guardian(s)/caregiver(s) will attend weekly hour long family-based psychosocial intervention to work on their top 2 modifiable SSD-risk factors targeted by the risk reduction therapy (RRT)

Study Details

The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults with a family history of SSD and high versus low baseline SSD-like brain patterns

Key Dates

First listed

Aug 4, 2026

Start date

Sep 1, 2026

Status verified

Jul 2026

Primary completion

Apr 1, 2031

Completion

Apr 1, 2031

Study Design

Enrollment

100 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Arms

• Experimental: Psychosocial intervention group

Primary Outcome Measure

Change in persistent distressing psychotic-like experiences as assessed by a modified Prodromal Questionnaire Brief-Child Version (PQ-BC) questionnaire [ Time Frame: Baseline, 8 weeks, end of intervention (16 weeks after baseline ), 1-year follow up ]

Central Contacts

• Yizhou Ma, PhD
  713-486-2740
  [email protected]
• Oluwabunmi Akindona, BA
  713-486-2740
  [email protected]

Locations (1)

Find similar trials in Houston, TX