Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention

Part of paid clinical trials in Houston, Texas.

Sponsor
The University of Texas Health Science Center, Houston
Study ID
NCT07743645
Status
Not Yet Recruiting

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Conditions

  • Family History of Schizophrenia Spectrum Disorder
  • Prevention
  • Risk Factors for Mental Illness

Eligibility Criteria

Sex
ALL
Age
9 Years - 19 Years
Healthy Volunteers
Accepted

Interventions

  • Psychosocial intervention group — BEHAVIORAL
    Over 16 weeks, participants and their parent/legal guardian(s)/caregiver(s) will attend weekly hour long family-based psychosocial intervention to work on their top 2 modifiable SSD-risk factors targeted by the risk reduction therapy (RRT)

Study Details

The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults with a family history of SSD and high versus low baseline SSD-like brain patterns

Key Dates

First listed
Aug 4, 2026
Start date
Oct 1, 2026
Status verified
Jul 2026
Primary completion
Apr 1, 2031
Completion
Apr 1, 2031

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION

Arms

  • Experimental: Psychosocial intervention group

Primary Outcome Measure

Change in persistent distressing psychotic-like experiences as assessed by a modified Prodromal Questionnaire Brief-Child Version (PQ-BC) questionnaire [ Time Frame: Baseline, 8 weeks, end of intervention (16 weeks after baseline ), 1-year follow up ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of Texas Health Science Center at HoustonHoustonTexas77030
Yizhou Ma, PhD
[email protected]
713-486-2700
L. Elliot Hong, MD
[email protected]
713-486-2500

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By research site
The University of Texas Health Science Center at Houston· Houston, TX

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