Pneumococcal Carriage Duration

Conditions

• Pneumococcal Carriage

Eligibility Criteria

Sex

ALL

Age

28 Days - 48 Months

Healthy Volunteers

Accepted

Interventions

• Oropharyngeal (OP) swab — OTHER
  At each study visit, a double-tipped OP swab will be collected by trained clinical research staff. All swabs will be collected using a standard protocol. There will be 26 total study visits over the course of one year.

Study Details

Streptococcus pneumoniae (SPN) remains a leading cause of respiratory disease in young children despite widespread vaccination. Understanding the duration of pneumococcal carriage, patterns of co-colonization, and the influence of viral infections and the respiratory microbiome is essential to evaluate next-generation pneumococcal vaccines and inform public health strategies. Current data on Streptococcus pneumoniae carriage dynamics are limited in U.S. pediatric populations. This study aims to generate updated estimates of Streptococcus pneumoniae colonization and explore microbial interactions using high-resolution longitudinal sampling and genomic methods.

Key Dates

First listed

Aug 6, 2026

Start date

Jul 21, 2026

Status verified

Aug 2026

Primary completion

Jul 31, 2027

Completion

Jul 31, 2027

Study Design

Enrollment

60 participants (estimated)

Arms

• Arm: Main Cohort
  60 healthy children under 4 years of age (30 children aged 0-1 years, 30 children aged 2-4 years) residing in Orlando, Florida.

Primary Outcome Measure

Estimate the age- and serotype-specific carriage duration of Streptococcus pneumoniae in children aged 0-4 years. [ Time Frame: One year ]

Central Contacts

• Dr. Amoy Fraser, PhD
  407-266-8742
  [email protected]
• Aniya Barclay, MS
  407-266-8742
  [email protected]

Locations (1)

Find similar trials in Orlando, FL

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