Paid Clinical Trials in Orlando, FL
As of August 2026, 699 paid clinical trials are recruiting in Orlando, Florida. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Orlando offers studies at sites including AdventHealth Orlando for conditions such as Breast Cancer, Obesity, Ovarian Cancer, Crohn's Disease. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Orlando
Trials by drug in Orlando
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Newly added in Orlando
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
A Study to Assess the Efficacy and Safety of Solriamfetol in Children With ADHD
A Study to Assess the Efficacy and Safety of Solriamfetol in Adolescents With ADHD
Randomized Trial of Percutaneous vs. Endoscopic Gallbladder Drainage
EUS Procedures Using RIVOS™ EUS Access Device
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)
642 clinical trials
A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)
A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH)
Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Phase 2 Study to Assess the Safety and Efficacy of ANG003
A Study of Brenipatide in Adult Participants With Schizophrenia
Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease
Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study
Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)
A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)
A Study of Brenipatide in Participants With Alcohol Use Disorder
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
Top Research Study Locations in Orlando
Researchers run research studies in Orlando, FL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| AdventHealth Orlando | Heart Failure, Acute Myeloid Leukemia, Malignant Solid Neoplasm | 59 |
| Nemours Children's Hospital | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm | 38 |
| Arnold Palmer Hospital for Children | Neuroblastoma, B Acute Lymphoblastic Leukemia, Osteosarcoma | 37 |
| Orlando Health | Acute Pancreatitis, Endometrial Cancer, Obesity or Overweight | 32 |
| AdventHealth | Acute Pancreatitis, Cervical Cancer, Colonic Neoplasms | 30 |
| Orlando Health Cancer Institute | Carcinoma, Non-Small-Cell Lung, Metastatic Melanoma, Metastatic Renal Cell Carcinoma | 29 |
| University of Central Florida | Biospecimen Donation, Breast Cancer, HIV | 29 |
| Advent Health | Colorectal Cancer, Ovarian Cancer, Advanced Malignant Neoplasm | 17 |
| Orlando Clinical Research Center | Healthy, Hepatic Impairment, Hepatic Insufficiency | 16 |
| Advent Health Orlando | Acute Kidney Injury, Atrial Fibrillation, Brain Tumor | 11 |
| Charter Research | Major Depressive Disorder, Mild Cognitive Impairment, Agitation Associated With Alzheimer's Dementia | 11 |
| Florida Cancer Specialists | Breast Cancer, Carcinoma, Non-Small-Cell Lung, Gastroesophageal Junction Adenocarcinoma | 10 |
| Sarah Cannon Research Institute at Florida Cancer Specialists | Advanced Solid Tumor, Mesothelioma, Adenocarcinoma of Esophagus | 9 |
| AdventHealth Cancer Institute | Advanced Solid Tumor, Ovarian Cancer, Platinum-resistant Ovarian Cancer | 8 |
| Clinical Neuroscience Solutions, Inc. | Major Depressive Disorder, Atopic Dermatitis, Attention-Deficit/Hyperactivity Disorder | 8 |
| GSK Investigational Site | HIV Infections, Pulmonary Disease, Chronic Obstructive, Gastrointestinal Neoplasms | 7 |
| Charter Research - Orlando | Alcohol Use Disorder, Alzheimer Disease, Amyloid | 7 |
| AdventHealth Translational Research Institute | Type 2 Diabetes, Hepatic Steatosis, Insulin Resistance | 6 |
| Nemours Children's Health | Acute Pain, Bronchiolitis, Bronchodilator Agents | 6 |
| Orlando Health Orlando Regional Medical Center | Non-Small Cell Lung Cancer, Advanced Non-Small Cell Lung Cancer, Advanced Renal Cell Carcinoma | 6 |
| CTR Oakwater, LLC | Focal Segmental Glomerulosclerosis, Kidney Disease, Primary Membranous Nephropathy | 5 |
| Central Florida Pulmonary Group | Cystic Fibrosis (CF), Cardiovascular Diseases, Chronic Pseudomonas Aeruginosa Infection | 5 |
| Digestive and Liver Center of Florida | Obesity or Overweight, Ulcerative Colitis, Crohn's Disease | 5 |
| Orlando Health Digestive Health Institute | Acute Cholecystitis, Biliary Obstruction, Chronic Pancreatitis | 5 |
| Orlando Regional Medical Center | Anastomotic Leaks, Chronic Low-back Pain, Chronic Subdural Hematoma | 5 |
Active & Upcoming Studies in Orlando (2026)
Recruiting trials in Orlando grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (185 active studies)
- Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02) · Phase 3 · Bristol-Myers Squibb
- EUS Procedures Using RIVOS™ EUS Access Device · Orlando Health, Inc.
Diabetes & metabolic (45 active studies)
Neurology & pain (43 active studies)
- A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery · Phase 3 · AFT Pharmaceuticals, Ltd.
- A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain · Phase 3 · AFT Pharmaceuticals, Ltd.
Cardiovascular (36 active studies)
- Dual-Language B-MORE for Hypertension · Florida State University
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity · Phase 3 · Novo Nordisk A/S
Mental health & behavior (14 active studies)
- A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD) · Phase 2 · Tonix Pharmaceuticals, Inc.
- A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively · Phase 3 · Karuna Therapeutics, Inc., a Bristol Myers Squibb company
HIV / STI (10 active studies)
- A Study to Investigate Cabotegravir Ultra Long-Acting (CAB ULA) Plus Rilpivirine Ultra Long-Acting (RPV ULA) in Adults and Adolescents With HIV Who Are Virologically Suppressed · Phase 3 · ViiV Healthcare
- REINItiation of Antiretroviral Therapy Using Oral bicTegravir, emtrIcitAbine and Tenofovir alafenamidE · Phase 4 · CAN Community Health
Eye & vision (7 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) · Phase 3 · Adverum Biotechnologies, Inc.
Pediatric (6 active studies)
- Measuring Aided Language Development · University of Central Florida
- Role of Body Composition in Large for Gestational Age Infants (LGA) With Oral Feeding Difficulty · Nemours Children's Clinic
Vaccines (1 active study)
- A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023) · Phase 3 · Merck Sharp & Dohme LLC
Common conditions studied in Orlando
- Breast Cancer (15 active studies)
- Obesity (14 active studies)
- Ovarian Cancer (13 active studies)
- Crohn's Disease (12 active studies)
- Heart Failure (12 active studies)
- Ulcerative Colitis (12 active studies)
Leading research sponsors in Orlando
- University of Central Florida
- Eli Lilly and Company
- Children's Oncology Group
- AstraZeneca
- Pfizer
Frequently asked questions
How many paid clinical trials are currently recruiting in Orlando?
There are approximately 699 recruiting clinical trials in Orlando, Florida listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Orlando pay participants?
Most recruiting trials in Orlando compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Orlando?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Orlando?
The most common conditions under active study in Orlando include Breast Cancer (15), Obesity (14), Ovarian Cancer (13), Crohn's Disease (12), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Orlando?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Orlando on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Orlando?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Orlando?
Recruiting research sites in Orlando include AdventHealth Orlando, Nemours Children's Hospital, Arnold Palmer Hospital for Children, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Orlando right now?
The largest active categories in Orlando are Cancer & tumors (185), Diabetes & metabolic (45), Neurology & pain (43). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.