Mechanistic Validation of Human Multipolar TES-TI: Amplitude Modulation, Frequency, and Benchmarking

Conditions

• Transcranial Electric Stimulation

Eligibility Criteria

Sex

ALL

Age

18 Years - 50 Years

Healthy Volunteers

Accepted

Interventions

• TES-TI with hdEEG — DEVICE
  4 conditions per session. Each condition will follow a standardized block structure consisting of 3 minutes pre-stimulation baseline, 3 minutes stimulation, and 3 minutes post-stimulation recording (PRE, STIM, POST)

Study Details

This study is to find out whether and how a type of non-invasive electrical brain stimulation called transcranial electrical stimulation with temporal interference (TES-TI) can temporarily change brain activity in healthy adults. A structural MRI scan will be used to customize where the stimulation electrodes are placed for each participant to deliver TES-TI during three afternoon sessions at rest with eyes closed. Brain activity is recorded with high-density EEG. Up to 24 participants will be enrolled and on study for 3 to 12 weeks.

Key Dates

First listed

Aug 7, 2026

Start date

Sep 30, 2026

Status verified

Aug 2026

Primary completion

Feb 29, 2028

Completion

Feb 29, 2028

Study Design

Enrollment

24 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Session A: Amplitude Modulation Specificity
  hdEEG setup; eyes-closed wakefulness 4 conditions in randomized order: * in-phase mTI (10 Hz) * mixed unipolar+HF * HF control (no envelope) * SHAM PRE 3 min / STIM 3 min / POST 3 min per condition Adverse events assessment
• Experimental: Session B: Benchmarking
  hdEEG setup; eyes-closed wakefulness 4 conditions in randomized order: * in-phase mTI (10 Hz) * unipolar TES-TI 5 mA * unipolar TES-TI 8 mA * SHAM PRE 3 min / STIM 3 min / POST 3 min per condition Adverse events assessment
• Experimental: Session C: Frequency Dependence
  hdEEG setup; eyes-closed wakefulness 4 conditions in randomized order: * in-phase mTI at 10 Hz * in-phase mTI at 50 Hz * in-phase mTI at 130 Hz * SHAM PRE 3 min / STIM 3 min / POST 3 min per condition Adverse events assessment

Primary Outcome Measure

Change in band-limited, topography-resolved EEG spectral power during stimulation for conditions in Session A [ Time Frame: data collected for 3 minutes prior to stimulation and 3 minutes during stimulation for each of 4 conditions during Session A (approximately 3 hours long) ]

Central Contacts

• MINT Study Team
  608-263-4313
  [email protected]

Locations (1)

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