Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Elizabeth B Klerman MD PhD
Study ID
NCT07753889
Status
Not Yet Recruiting

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Conditions

  • Circadian Rhythm
  • Pupillometry
  • Sleep

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Ocular light exposure from portable light box — OTHER
    One night of dim light exposure and one night of bright light exposure. Lighting from the portable light box

Study Details

The investigators are studying relationships among eye pathology, pupil responses to light, sleep, circadian rhythms, and hormones in healthy individuals and those with various medical disorders or illnesses. All participants will: * Answer questionnaires about their health * Receive an eye exam, * For one week at home, participants will track their sleep and wake using actigraphy (wrist worn wearable) and an online sleep diary. * Complete a pupillometry session (measuring pupil size in response to different lighting) at MGH Participants may also choose to participate in the following additional procedures in any order: * Within one week of their pupillometry session, an at-home saliva collection under dim light. Saliva melatonin can be analyzed to determine Dim-Light-Melatonin-Onset (DLMO), a marker of circadian timing. * If participants participate in one night saliva collection, a second night of at-home saliva collection with a bright light exposure to calculate melatonin suppression in response to light.

Key Dates

First listed
Aug 10, 2026
Start date
Sep 1, 2027
Status verified
Sep 2026
Primary completion
Dec 31, 2034
Completion
Dec 31, 2035

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Lighting intervention
    Pupillometry at MGH following by saliva collection during one night of dim light and then one night of bright light

Primary Outcome Measure

Pupil size [ Time Frame: 1 hour of pupillometry ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
MassGeneralBrighamBostonMassachusetts02114
Elizabeth Klerman, MD PhD
[email protected]
617-643-2424

Find similar trials in Boston, MA

By research site
MassGeneralBrigham· Boston, MA

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